Areas of Nonperfusion in Peripheral Retina of Eyes With Pathologic Myopia Detected by Ultra-Widefield Fluorescein Angiography

2014 ◽  
Vol 55 (3) ◽  
pp. 1432 ◽  
Author(s):  
Yuichiro Kaneko ◽  
Muka Moriyama ◽  
Shuichiro Hirahara ◽  
Yuichiro Ogura ◽  
Kyoko Ohno-Matsui
Keyword(s):  
Fluorescein Angiography ◽  
Peripheral Retina ◽  
Pathologic Myopia

scholarly journals Comparison of fundus fluorescein angiography, optical coherence tomography and optical coherence tomography angiography features of macular changes in Eales disease: a case series

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ketaki Rajurkar ◽  
Meenakshi Thakar ◽  
Priyadarshi Gupta ◽  
Anju Rastogi
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Optical Coherence Tomography Angiography ◽  
Disease Process ◽  
Cystoid Macular Oedema ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Indirect Ophthalmoscopy ◽  
Eales Disease

Abstract Purpose To study the macular features in Eales disease patients observed with fundus fluorescein angiography (FA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods A cross-sectional study was done on treatment naïve 31 eyes (23 patients) with Eales disease. Baseline parameters such as Best-corrected visual acuity (BCVA), slit-lamp bio microscopy (SLB), indirect ophthalmoscopy, FA, spectral-domain OCT {quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT} and OCTA were performed. Any media opacity precluding the above investigations was excluded. Results Macular findings comprised of- epiretinal membrane, macular exudation, full thickness macular hole, sub internal limiting membrane bleed, cystoid macular oedema, neurosensory detachment and retinal thickening. Sixteen (51.6%) of our patients had macular changes as seen on all modalities together. SLB and indirect ophthalmoscopy missed macular findings in 50% patients and FA in 18.8% patients. OCT and OCTA diagnosed all macular findings. On comparison of mean BCVA in patients with macular involvement on FA, OCT and OCTA, compared to those without macular involvement, patients with macular involvement had lower BCVA (p 0.000, 0.01 and 0.001 respectively). Thus, FA missed many patients who had significant macular involvement and hence less vision. Conclusion Eales disease though described in literature as classically being peripheral retina disease process, also has macular involvement. OCT and OCTA are useful guides to evaluation of macular involvement in these patients. The latter seems to be superior to FA in detecting macular abnormalities in this ailment. OCTA is non-invasive and shows deep capillary plexus changes which are not shown by any other modality.

FLUORESCEIN ANGIOGRAPHY OF EXTREME PERIPHERAL RETINA AND RUBEOSIS IRIDIS IN PROLIFERATIVE DIABETIC RETINOPATHY

Retina ◽  
1999 ◽  
Vol 19 (4) ◽  
pp. 302-308 ◽  
Author(s):  
HIROKO TERASAKI ◽  
YOZO MIYAKE ◽  
MASAKO MORI ◽  
TOSHIMITU SUZUKI ◽  
MINEO KONDO
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Proliferative Diabetic Retinopathy ◽  
Peripheral Retina ◽  
Rubeosis Iridis

scholarly journals Differential distribution of manifest lesions in diabetic retinopathy by fundus fluorescein angiography and fundus photography

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaoli Li ◽  
Jie Xie ◽  
Liang Zhang ◽  
Ying Cui ◽  
Guanrong Zhang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Posterior Pole ◽  
Chinese Patients ◽  
Fundus Photography ◽  
Peripheral Retina ◽  
Multiple Logistic Regression ◽  
Fundus Fluorescein Angiography ◽  
Differential Distribution ◽  
Nonproliferative Diabetic Retinopathy

Abstract Background To analyze the distribution of manifest lesions of diabetic retinopathy (DR) by fundus fluorescein angiography (FFA) and color fundus photography (FP). Methods A total of 566 eyes of 324 Chinese patients diagnosed with DR were included in this retrospective study. DR severity was graded by the international grading criterion. The distributions of microaneurysms (MA), intraretinal hemorrhages/exudates (He/Ex), intraretinal microvascular abnormality (IRMA), capillary nonperfusion areas (NPA), and neovascularization (NV) were estimated by multiple logistic regression analyse based on nine-field FFA and FP images. Results In mild nonproliferative diabetic retinopathy (NPDR), the highest frequency of MA was found in the posterior pole (67.7%), followed by the inferior nasal (59.4%), and the nasal (55.4%) fields. In moderate NPDR, MA frequently distributed in the posterior pole (98.0%), nasal (97.0%), superior (96.0%), inferior nasal (94.9%), and inferior (92.9%) fields, whereas He/Ex were most prevalent in the posterior pole (69.7%). In severe NPDR and proliferative DR, IRMA, NPA, and NV were more frequent in the nasal field, particularly in the inferior nasal field (60.3, 38.7, and 76.0%, respectively). All lesions were more observed in the combined posterior pole, nasal, and inferior nasal fields than in the posterior pole or combined two fields in the early and severe stages of DR (P < 0.05). Conclusions The manifest lesions of DR were common in the nasal field besides the posterior pole in Chinese patients. A combined examination of the posterior pole, nasal, and inferior nasal mid-peripheral retina would help to detect different retinal lesions of DR. Trial registration ClinicalTrial. gov, NCT03528720. Registered 18 May 2018 - Retrospectively registered.

Retinal Findings of a Unique RTEL1 Mutation in Dyskeratosis Congenita

2017 ◽  
Vol 1 (6) ◽  
pp. 411-414
Author(s):  
Benjamin G. Wajda ◽  
Alexander S. Platt ◽  
April D. Ingram ◽  
Anna L. Ells
Keyword(s):  
Fluorescein Angiography ◽  
Telomere Length ◽  
Laser Photocoagulation ◽  
Dyskeratosis Congenita ◽  
Peripheral Retina ◽  
Wide Field ◽  
Inherited Disease ◽  
Fundus Imaging ◽  
Pan Retinal Photocoagulation ◽  
Retinal Photocoagulation

We describe the retinal manifestations of a patient with a unique mutation of the Regulator of telomere length 1 ( RTEL1) gene resulting in dyskeratosis congenita (DC), a rare, fatal, inherited disease. A 4-year-old boy with DC was referred for ophthalmology consult by his attending hematologist and underwent a complete ophthalmic examination, including wide-field fundus imaging and fluorescein angiography. The patient was found to have bilateral retinal vasculopathy and extensive microvascular abnormalities in addition to avascular regions in the temporal peripheral retina. He received multiple pan-retinal photocoagulation treatments in both eyes. Our case highlights the importance of ophthalmic screening and fluorescein angiography and the potential need for timely laser photocoagulation for sight-threatening retinopathy in patients with DC.

Observation of the far peripheral retina of normal eyes by ultra-wide field fluorescein angiography

2020 ◽  
pp. 112067212092645
Author(s):  
Xiaoling Wang ◽  
A’min Xu ◽  
Zuohuizi Yi ◽  
Lu He ◽  
Juejun Liu ◽  
...  
Keyword(s):  
Fluorescein Angiography ◽  
Imaging System ◽  
Late Phase ◽  
Clinical Work ◽  
Cross Sectional Study ◽  
Peripheral Retina ◽  
Wide Field ◽  
Cross Sectional ◽  
Avascular Area ◽  
Visual Disturbances

Purpose The appearance of the far peripheral retina in normal eyes was observed using an Optos ultra-wide field fluorescein angiography imaging system. Methods A cross-sectional study of ultra-wide field pseudocolor and angiography images obtained using the Optos 200Tx. Four different non-vascular and six vascular-associated fluorescence features in far peripheral retina were analyzed. Results A total of 166 eyes in 83 patients met the inclusion criteria. The mean patient age was 40.78 ± 10.94 years (range: 20–65 years) with a female-to-male ratio of 0.98. Slight cataract were present in 64 eyes (38.55%), low to moderate myopia in 50 eyes (30.12%), and unspecified visual disturbances in 52 eyes (31.33%). Far peripheral retinas were found to have mottled florescent band in 42.17% eyes, ground glass hyperfluorescence in 84.34% eyes, granular hyperfluorescence in 12.65% eyes, local mottled fluorescence in 10.84% eyes, vascular anastomosis with a peripheral avascular area in 36.23% eyes, invisible capillary details in 50.67% eyes, vessels passing through the ora serrata in 16.98% eyes, late-phase slight leakage in 32.53% eyes, angiectasis in 18.67% eyes, and microaneurysm in 34.94% eyes. Conclusion Ultra-wide field fluorescein angiography revealed various fluorescence features in the periphery of normal eyes, providing a basis for interpreting normal and pathological changes in peripheral retina and an important reference for clinical work.

Appearance of Far Peripheral Retina in Normal Eyes by Ultra-widefield Fluorescein Angiography

2017 ◽  
Vol 173 ◽  
pp. 84-90 ◽  
Author(s):  
Jing Lu ◽  
Guiying Mai ◽  
Yan Luo ◽  
Mei Li ◽  
Di Cao ◽  
...  
Keyword(s):  
Fluorescein Angiography ◽  
Peripheral Retina

Fluorescein Angiography of Persistent Incomplete Vascularization of the Retina After Bevacizumab Therapy in Retinopathy of Prematurity

2019 ◽  
Vol 3 (5) ◽  
pp. 304-308 ◽  
Author(s):  
Xihui Lin ◽  
Sagar B. Patel ◽  
Alice Y. Zhang ◽  
Daniel A. Brill ◽  
Kim H. Le ◽  
...  
Keyword(s):  
Fluorescein Angiography ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Case Series ◽  
Intravitreal Bevacizumab ◽  
Peripheral Retina ◽  
Medical Systems ◽  
Retrospective Case ◽  
Type 1 Rop

Purpose: This study evaluates the vascular development of premature infants at 50 weeks postconception after treatment with intravitreal bevacizumab for type 1 retinopathy of prematurity (ROP). Methods: A retrospective case series was conducted on type 1 ROP neonates with a high risk of general anesthesia complications. Patients were treated with bevacizumab between February 2013 and February 2016. At 50 weeks’ gestational age, all patients were imaged with RetCam (Clarity Medical Systems, Inc) fundus photographs and widefield fluorescein angiography (FA). Results: There were 4 boys and 7 girls with an average gestational age of 24.8 weeks and weight of 734.3 grams at birth. The estimated gestational age at injection was 37.1 weeks. Examination under anesthesia with FA was performed at a mean of 61 weeks posttreatment. Nineteen of 20 eyes (95%) of 11 infants had incomplete vascularization and peripheral nonperfusion on imaging. FA showed new vessels with increased tortuosity, microvascular abnormalities, and leakage past the original ridge. These 19 patients were treated with confluent ablative photocoagulation to the peripheral nonperfused retina. Patients were followed for a mean of 73.3 weeks after birth. None required incisional surgery. Conclusions: Patients with type 1 ROP treated with bevacizumab may have delayed vascularization of the peripheral retina and even late recurrence of active disease. Clinicians should regularly monitor patients after bevacizumab for potential neovascular complications.

scholarly journals Correlation between the Nonperfusion Area on Ultra-Widefield Fluorescein Angiography and Nonflow Area on Optical Coherence Tomographic Angiography in Retinal Vein Occlusion

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jianfeng Huang ◽  
Yingyi Lu ◽  
Xiaoya Gu ◽  
Bodi Zheng ◽  
Tong Chen
Keyword(s):  
Fluorescein Angiography ◽  
Retinal Vein Occlusion ◽  
Statistical Testing ◽  
Foveal Avascular Zone ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Vein Occlusion ◽  
Capillary Plexus ◽  
Temporal Quadrant ◽  
Tomographic Angiography

Aims. To compare the relationship between the nonperfusion area (NPA) on ultra-widefield fluorescein angiography (UWFFA) and the nonflow area (NFA) on optical coherence tomographic angiography (OCTA) in retinal vein occlusion (RVO). Methods. Cross-sectional study. 46 eyes of 46 RVO patients who underwent UWFFA and OCTA. NPA and ischemic index (ISI) were quantified on UWWFA. NFA, vessel density (VD) of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the size foveal avascular zone (FAZ) on 3 ∗ 3 mm OCTA were measured. The association of the NPA and ISI on UWWFA and the parameters on OCTA were analyzed. Spearman correlation was used for statistical testing. Results. The NPA and ISI on UWFFA were significantly correlated with the NFA on OCTA in RVO, and r values were 0.688 ( p < 0.01 ) and 0.680 ( p < 0.01 ), respectively. VD in the SCP of the temporal quadrant was negatively correlated with NPA and ISI, and r values were −0.346 ( p < 0.05 ) and −0.337 ( p < 0.05 ), respectively. VD in the DCP of the temporal quadrant was negatively correlated with the NPA, and the r value was −0.246 ( p < 0.05 ). No significant correlation was found between the NPA and ISI on UWFFA and VD of other quadrants in the SCP or DCP and the FAZ area on OCTA. Conclusion. NPA in the peripheral retina was correlated with NFA in macula. NFA detected by OCTA could be an indicator of the ischemic status in RVO.

scholarly journals Ocular syphilis with optic disc neovascularization treated with bevacizumab evaluated by OCT angiography and electroretinography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gen Miura ◽  
Takayuki Baba ◽  
Marie Takeishi ◽  
Tomoaki Tatsumi ◽  
Hirotaka Yokouchi ◽  
...  
Keyword(s):  
Fluorescein Angiography ◽  
Optic Disc ◽  
Intravitreal Bevacizumab ◽  
Oct Angiography ◽  
Peripheral Retina ◽  
Panretinal Photocoagulation ◽  
Initial Examination ◽  
Ocular Syphilis ◽  
Oral Amoxicillin ◽  
One Year

Abstract We present our findings in an atypical case of ocular syphilis with optic disc neovascularization that was treated with intravitreal bevacizumab and followed by multimodal imaging and electroretinography. A 29-year-old man presented with a chief complaint of night blindness of one-year duration. Our initial examination showed that an optic disc neovascularization was present, and the optical coherence tomographic (OCT) images showed a reduction in the length of the ellipsoid zone of both eyes. Fluorescein angiography showed leakage from the optic disc neovascular tissue, and the presence of nonperfused areas in the peripheral retina. Blood test was strongly positive for syphilis. He was administered oral amoxicillin and prednisolone. He was also treated with an intravitreal injection of bevacizumab which led to a rapid suppression of the neovascularization. However, panretinal photocoagulation had to be performed because OCT angiography and fluorescein angiography detected residual neovascularization. Although these treatments suppressed the activity of the ocular syphilis, electrophysiological improvements were not seen even 1 year after the initial treatment. OCT angiography and electroretinogram are useful techniques for monitoring the effectiveness of the treatments.

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