Observation of the far peripheral retina of normal eyes by ultra-wide field fluorescein angiography

2020 ◽  
pp. 112067212092645
Author(s):  
Xiaoling Wang ◽  
A’min Xu ◽  
Zuohuizi Yi ◽  
Lu He ◽  
Juejun Liu ◽  
...  
Keyword(s):  
Fluorescein Angiography ◽  
Imaging System ◽  
Late Phase ◽  
Clinical Work ◽  
Cross Sectional Study ◽  
Peripheral Retina ◽  
Wide Field ◽  
Cross Sectional ◽  
Avascular Area ◽  
Visual Disturbances

Purpose The appearance of the far peripheral retina in normal eyes was observed using an Optos ultra-wide field fluorescein angiography imaging system. Methods A cross-sectional study of ultra-wide field pseudocolor and angiography images obtained using the Optos 200Tx. Four different non-vascular and six vascular-associated fluorescence features in far peripheral retina were analyzed. Results A total of 166 eyes in 83 patients met the inclusion criteria. The mean patient age was 40.78 ± 10.94 years (range: 20–65 years) with a female-to-male ratio of 0.98. Slight cataract were present in 64 eyes (38.55%), low to moderate myopia in 50 eyes (30.12%), and unspecified visual disturbances in 52 eyes (31.33%). Far peripheral retinas were found to have mottled florescent band in 42.17% eyes, ground glass hyperfluorescence in 84.34% eyes, granular hyperfluorescence in 12.65% eyes, local mottled fluorescence in 10.84% eyes, vascular anastomosis with a peripheral avascular area in 36.23% eyes, invisible capillary details in 50.67% eyes, vessels passing through the ora serrata in 16.98% eyes, late-phase slight leakage in 32.53% eyes, angiectasis in 18.67% eyes, and microaneurysm in 34.94% eyes. Conclusion Ultra-wide field fluorescein angiography revealed various fluorescence features in the periphery of normal eyes, providing a basis for interpreting normal and pathological changes in peripheral retina and an important reference for clinical work.

Fundus examination of 199 851 newborns by digital imaging in China: a multicentre cross-sectional study

2018 ◽  
Vol 102 (12) ◽  
pp. 1742-1746 ◽  
Author(s):  
He Tang ◽  
Na Li ◽  
Zhan Li ◽  
Meiju Zhang ◽  
Meirong Wei ◽  
...  
Keyword(s):  
Digital Imaging ◽  
Large Scale ◽  
Imaging System ◽  
Cross Sectional Study ◽  
Wide Field ◽  
Fundus Examination ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ocular Abnormalities ◽  
Ocular Health

BackgroundThe prevalence of ocular abnormalities of newborn in China has seldom been reported. To report the implementation of digital imaging in ocular screening of all newborns in multiple centres in China and to describe the abnormal findings of fundus examination, we did the cross-sectional study.MethodsFundus examinations were performed on newborns within the 42 days after birth using a RetCam wide-field digital imaging system. Digital images of the posterior pole, superior, nasal and temporal retinal fields of each participant were taken. All newborns were from eights centres across China from January 2009 to July 2017.ResultsA total of 199 851 newborns were included in the study. We detected 18 198 (9.11%) abnormal cases. The most frequent abnormality was severe retinal haemorrhage (RH) found in 12 810 cases (6.41%). The other anomalies included familial exudative vitreoretinopathy, retinopathy of prematurity, abnormal fundus pigmentation, subconjunctival haemorrhage, choroidal coloboma, idiopathic retinal venous tortuosity, exudative changes and other anomalies with uncertain identities.ConclusionThis large-scale study of newborn fundus examination showed a relatively high prevalence of ocular abnormalities. Hundreds of neonates with rare disorders that severely impair ocular health were also detected at an early age. The long-term impact of other anomalies including RHs on the ocular system should be investigated by a perspective study. Our study suggested that fundus examination of newborns can play a beneficial role in ocular health.

scholarly journals Neonatal Eye Screening for 203 Healthy Term Newborns Using a Wide-Field Digital Retinal Imaging System

2020 ◽  
Author(s):  
Kenneth Teow Kheng Leong ◽  
Siti Nur Amira Abu Kassim ◽  
Jasvinjeet Kaur Sidhu ◽  
Zayani Zohari ◽  
Thivakar Sivalingam ◽  
...  
Keyword(s):  
Imaging System ◽  
Newborn Infants ◽  
Cross Sectional Study ◽  
Common Finding ◽  
Wide Field ◽  
Retinal Haemorrhage ◽  
Cross Sectional ◽  
Ocular Abnormalities ◽  
Lower Segment Caesarean Section ◽  
Retinal Haemorrhages

Abstract Purpose: This study aimed to determine the proportion and types of ocular abnormalities detected in healthy term newborns and also the risk factors associated with retinal haemorrhages.Method: This cross-sectional study comprised of 203 participants, all healthy term newborn infants in the Obstetrics and Gynaecology ward at Hospital Kuala Lumpur over a six months period. The examination list includes external eye examination, red reflex test, and fundus imaging using a wide-field digital retinal imaging system (Phoenix Clinical ICON Paediatric Retinal Camera) by a trained Investigator. The pathologies detected were documented. The results were compared with similar studies previously published in the literature.Results: Total ocular abnormalities were detected in 34% infants. The most common finding was retinal haemorrhage in 29.6% infants, of which 53.3% occurred bilaterally. Spontaneous vaginal delivery (SVD) remained the greatest risk factor which has nearly 3.5 times higher risk of newborns developing retinal haemorrhage compared to Lower Segment Caesarean Section (LSCS). There was a 6% increased likelihood of developing retinal haemorrhage for every 1 minute increment in the duration of 2nd stage of labour. Conclusion: Universal eye screening for all newborns using a wide-field digital imaging system is possible, safe and useful in detecting posterior segment disorders. The most common abnormality detected is retinal haemorrhage. Although most resolve spontaneously, a longitudinal study is needed to study the long term effect of retinal haemorrhages in these infants.

scholarly journals A Cross-Sectional Study of Experiences and Attitudes towards Clinical Audit of Farm Animal Veterinary Surgeons in the United Kingdom

2018 ◽  
Vol 5 (4) ◽  
pp. 84
Author(s):  
Katie Waine ◽  
Rachel S. Dean ◽  
Chris Hudson ◽  
Jonathan Huxley ◽  
Marnie L. Brennan
Keyword(s):  
Clinical Audit ◽  
Nationwide Survey ◽  
Clinical Work ◽  
Cross Sectional Study ◽  
Farm Animal ◽  
Sectional Study ◽  
Cross Sectional ◽  
Protected Time ◽  
Veterinary Surgeons ◽  
The Uk

Clinical audit is a quality improvement tool used to assess and improve the clinical services provided to patients. This is the first study to investigate the extent to which clinical audit is understood and utilised in farm animal veterinary practice. A cross-sectional study to collect experiences and attitudes of farm animal veterinary surgeons in the UK towards clinical audit was conducted using an online nationwide survey. The survey revealed that whilst just under three-quarters (n = 237/325; 73%) of responding veterinary surgeons had heard of clinical audit, nearly 50% (n = 148/301) had never been involved in a clinical audit of any species. The participants’ knowledge of what a clinical audit was varied substantially, with many respondents reporting not receiving training on clinical audit at the undergraduate or postgraduate level. Respondents that had participated in a clinical audit suggested that protected time away from clinical work was required for the process to be completed successfully. This novel study suggests that clinical audit is undertaken to some extent in farm animal practice and that practitioner perception is that it can bring benefits, but was felt that more resources and support were needed for it to be implemented successfully on a wider scale.

Psychological Impact during the Late Phase of Covid-19 Pandemic among the Hospitalised Patients and General Public in Andhra Pradesh - A Cross-Sectional Comparative Study

2021 ◽  
Vol 8 (21) ◽  
pp. 1614-1619
Author(s):  
Abdul Salaam Abdul Salaa ◽  
Ganga Raju Godasi ◽  
Raj Kiran Donthu ◽  
Ravi Shankar Pasam ◽  
Anand Acharya ◽  
...  
Keyword(s):  
General Public ◽  
Late Phase ◽  
Psychological Impact ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mean Values ◽  
R Language ◽  
Hospitalised Patients ◽  
Long Term Follow Up ◽  
Novel Coronavirus

BACKGROUND Coronavirus disease 2019 (Covid-19) is a novel coronavirus, which became a pandemic within few days. Being a novel virus, the disease pathophysiology and psychological impact are not completely known. Studies conducted till now concentrated on the initial phases of the pandemic. Our study tries to understand the psychological impact during the late phase of the pandemic. METHODS This is a cross sectional study involving Covid-19 hospitalised patients and the general public. Sociodemographic details were collected, and subjects were administered for depression, anxiety, and stress scale (DASS). A total of 301 participants were included. Data was analysed using R language. The scores from both the groups were compared to obtain the results. RESULTS Among the Covid-19 patients, almost 90 % have reported normal levels in depression and stress and 67 % in anxiety with mean values of 2.71, 5.91 and 4.74 respectively. Among the general public, more than 80 % have reported normal levels in depression, anxiety, and stress with mean scores of 5.58, 3.62 and 7.32 respectively. On comparing the raw scores of the two groups, significant differences in depression (P = 0 .000) anxiety (P = 0 .004) and stress (P = 0 .004) were noted. CONCLUSIONS Psychological impact during late phase of Covid-19 pandemic appears to be mild among both hospitalised patients and general public. Future studies should focus on long term follow up and should also include severe affected cases. KEYWORDS Covid-19, Mental Disorders, Pandemic

Neonatal eye screening for 203 healthy term newborns using a wide-field digital retinal imaging system

2019 ◽  
Author(s):  
Kenneth Teow Kheng Leong ◽  
Siti Nur Amira Abu Kassim ◽  
Jasvinjeet Kaur Sidhu ◽  
Zayani Zohari ◽  
Thivakar Sivalingam ◽  
...  
Keyword(s):  
Imaging System ◽  
Retinal Imaging ◽  
Common Finding ◽  
Wide Field ◽  
Retinal Haemorrhage ◽  
Cross Sectional ◽  
Ocular Abnormalities ◽  
Eye Screening ◽  
Term Newborns ◽  
Retinal Haemorrhages

Abstract Purpose This study aimed to determine the proportion and types of ocular abnormalities detected in healthy term newborns and also the risk factors associated with retinal haemorrhages. Method This cross-sectional study comprised of 203 participants, all healthy term newborn infants in the Obstetrics and Gynaecology ward at Hospital Kuala Lumpur over a six months period. The examination list includes external eye examination, red reflex test, and fundus imaging using a wide-field digital retinal imaging system (Phoenix Clinical ICON Paediatric Retinal Camera) by a trained Investigator. The pathologies detected were documented. The results were compared with similar studies previously published in the literature. Results Total ocular abnormalities were detected in 34% infants. The most common finding was retinal haemorrhage in 29.6% infants, of which 53.3% occurred bilaterally. Spontaneous vaginal delivery (SVD) remained the greatest risk factor which has nearly four times higher risk of newborns developing retinal haemorrhage compared to Lower Segment Caesarean Section (LSCS). There was a 6% increased likelihood of developing retinal haemorrhage for every 1 minute increment in the duration of 2nd stage of labour. Newborns delivered via SVD with episiotomy had 2.5 higher odds of developing retinal haemorrhage in newborns compared to SVD without episiotomy. Conclusion Universal eye screening for all newborns using a wide-field digital imaging system is possible, safe and useful in detecting posterior segment disorders. The most common abnormality detected is retinal haemorrhage. Although most resolve spontaneously, a longitudinal study is needed to study the long term effect of retinal haemorrhages in these infants.

Migraine With Aura and Migraine Without Aura: An Epidemiological Study

Cephalalgia ◽  
1992 ◽  
Vol 12 (4) ◽  
pp. 221-228 ◽  
Author(s):  
Birthe Krogh Rasmussen ◽  
Jes Olesen
Keyword(s):  
Migraine With Aura ◽  
Migraine Without Aura ◽  
International Headache Society ◽  
Age Distribution ◽  
Cross Sectional Study ◽  
Lifetime Prevalence ◽  
Headache Disorders ◽  
Cross Sectional ◽  
Visual Disturbances ◽  
Precipitating Factor

In a cross-sectional study of headache disorders in a representative general population of 1,000 persons the epidemiology of migraine with aura (MA) and migraine without aura (MO) was analysed in relation to sex and age distribution, symptomatology and precipitants. The headache disorders were classified on the basis of a clinical interview as well as a physical and a neurological examination using the operational diagnostic criteria of the International Headache Society (IHS). Lifetime prevalence of MA was 5%, male:female ratio 1:2. Lifetime prevalence of MO was 8%, M:F ratio 1:7. Women, but not men, were significantly more likely to have MO than MA. Neither MA nor MO showed correlation to age in the studied age interval (25–64 years). Premonitory symptoms occurred in 16% of subjects with MA and in 12% with MO. One or more precipitating factor was present in 61% with MA and in 90% with MO. In both MA and MO the most conspicuous precipitating factor was stress and mental tension. Visual disturbances were the most common aura phenomenon occurring in 90% of subjects with MA. Aura symptoms of sensory, motor or speech disturbances rarely occurred without coexisting visual disturbances. The pain phase of MA fulfilled the criteria for MO of the IHS. Headache was, however, less severe and shorter lasting in MA than in MO. Onset at menarche, menstrual precipitation, menstrual problems, influence of pregnancy and use of oral contraceptives all showed some relationship with the presence of MO and less with MA. The present findings suggest that MA and MO share the pain phase. Among subjects with MA and MO, 50% and 62%, respectively, had consulted their general practitioner because of migraine. Selection bias in previous clinical studies is demonstrated by comparisons with the present unselected sample.

Retinal Findings of a Unique RTEL1 Mutation in Dyskeratosis Congenita

2017 ◽  
Vol 1 (6) ◽  
pp. 411-414
Author(s):  
Benjamin G. Wajda ◽  
Alexander S. Platt ◽  
April D. Ingram ◽  
Anna L. Ells
Keyword(s):  
Fluorescein Angiography ◽  
Telomere Length ◽  
Laser Photocoagulation ◽  
Dyskeratosis Congenita ◽  
Peripheral Retina ◽  
Wide Field ◽  
Inherited Disease ◽  
Fundus Imaging ◽  
Pan Retinal Photocoagulation ◽  
Retinal Photocoagulation

We describe the retinal manifestations of a patient with a unique mutation of the Regulator of telomere length 1 ( RTEL1) gene resulting in dyskeratosis congenita (DC), a rare, fatal, inherited disease. A 4-year-old boy with DC was referred for ophthalmology consult by his attending hematologist and underwent a complete ophthalmic examination, including wide-field fundus imaging and fluorescein angiography. The patient was found to have bilateral retinal vasculopathy and extensive microvascular abnormalities in addition to avascular regions in the temporal peripheral retina. He received multiple pan-retinal photocoagulation treatments in both eyes. Our case highlights the importance of ophthalmic screening and fluorescein angiography and the potential need for timely laser photocoagulation for sight-threatening retinopathy in patients with DC.

scholarly journals Perception of Preparedness for Clinical Work Among New Residents: A Cross-sectional Study from Oman

2017 ◽  
Vol 32 (3) ◽  
pp. 201-206
Author(s):  
Hamed Al Sinawi ◽  
Mohammed Al Alawi ◽  
Ali Al Qubtan ◽  
Jaber Al Lawati ◽  
Assad Al Habsi ◽  
...  
Keyword(s):  
Clinical Work ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
New Residents

scholarly journals Hospital Admissions for Neurodegenerative Diseases during the First Wave of the COVID-19 Pandemic: A Nationwide Cross-sectional Study from Germany

2021 ◽  
Vol 11 (9) ◽  
pp. 1219
Author(s):  
Raphael Scherbaum ◽  
Eun Hae Kwon ◽  
Daniel Richter ◽  
Dirk Bartig ◽  
Ralf Gold ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Hospital Admissions ◽  
Late Phase ◽  
Cross Sectional Study ◽  
Care Utilization ◽  
Administrative Claims ◽  
Sectional Study ◽  
Cross Sectional ◽  
Relative Change ◽  
Peak Phase

(1) Background: The COVID-19 pandemic impacts healthcare utilization across all care settings and health conditions. The objective of this study was to determine changes in hospital admissions for neurodegenerative diseases (NDD) during the first COVID-19 wave in Germany; (2) Methods: This cross-sectional study used nationwide administrative claims data covering 1468 hospitals. The primary outcome was the year-to-year relative change in case numbers during a four-month study period (16 January–15 May 2020 vs. 2019) during the first pandemic wave. Secondary outcomes included year-to-year relative changes during a four-week peak phase (16 March–15 April) and changes between differential phases of the wave. The analyzed NDD comprised progressive supranuclear palsy (PSP), multiple system atrophy (MSA), Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and Huntington’s disease; (3) Results: Hospital admissions for any reason decreased by 16.7% in 2020 during the study period and by 36.6% during the peak phase, whereas admissions for NDD decreased by 27.6% and 65.0%, respectively. PSP cases decreased during the study period (−34.7%) and the peak phase (−68.1%) and stayed reduced in a late phase with falling COVID-19 numbers. MSA and ALS cases increased strongest after the peak, with ALS cases being comparatively weakly reduced during the study period (−17.3%) and peak phase (−51.7%); (4) Conclusions: Inpatient care utilization for NDD changed differentially during the first wave of the COVID-19 pandemic in Germany and showed a greater reduction than overall and general neurological admissions. Mitigating long-term health deterioration of this vulnerable subgroup is important to reduce morbidity and mortality in the future.

scholarly journals The patients’ perspective on the burden of idiopathic intracranial hypertension

2021 ◽  
Author(s):  
Max Witry ◽  
Christine Kindler ◽  
Johannes Weller ◽  
Andreas Linder ◽  
Ullrich Wüllner
Keyword(s):  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Sleep Disturbances ◽  
Online Survey ◽  
Cross Sectional Study ◽  
Increased Intracranial Pressure ◽  
Opening Pressure ◽  
Cross Sectional ◽  
Patients Perspective ◽  
Visual Disturbances

Abstract Background: Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure without evidence of a tumor or any other underlying cause. Headache and visual disturbances are frequent complaints of IIH patients, but little is known about other symptoms. In this study, we evaluated the patients’ perspective on the burden of IIH. Methods: For this cross-sectional study, we developed an online survey for patients with IIH containing standardized evaluations of headache (HIT-6), sleep (PROMIS Sleep Disturbance Scale) and depression (MDI) in relation to BMI, lumbar puncture opening pressure (LP OP) and treatment. Results: Between December 2019 and February 2020, 306 patients completed the survey. 285 (93%) were female, mean age was 36.6 years (± 10.8), mean BMI 34.2 (± 7.3) and mean LP OP at diagnosis was 37.8 cmH2O (± 9.5). 219 (72%) of the participants were obese (BMI ≥ 30); 251 (82%) reported severe impacting headaches, 140 (46%) were suffering from sleep disturbances and 169 (56%) from depression. Higher MDI scores correlated with higher BMI and increased sleep disturbances. Patients with a normalized LP opening pressure reported less headaches, less sleep disturbances and less depression than those with a constantly elevated opening pressure. Conclusion: In addition to headaches and visual disturbances, sleep disturbances and depression are frequent symptoms in IIH and contribute to the patients’ burden. Structured questionnaires can help to identify IIH patients’ needs and can lead to personalized and better treatment.

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