scholarly journals Differential distribution of manifest lesions in diabetic retinopathy by fundus fluorescein angiography and fundus photography

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaoli Li ◽  
Jie Xie ◽  
Liang Zhang ◽  
Ying Cui ◽  
Guanrong Zhang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Posterior Pole ◽  
Chinese Patients ◽  
Fundus Photography ◽  
Peripheral Retina ◽  
Multiple Logistic Regression ◽  
Fundus Fluorescein Angiography ◽  
Differential Distribution ◽  
Nonproliferative Diabetic Retinopathy

Abstract Background To analyze the distribution of manifest lesions of diabetic retinopathy (DR) by fundus fluorescein angiography (FFA) and color fundus photography (FP). Methods A total of 566 eyes of 324 Chinese patients diagnosed with DR were included in this retrospective study. DR severity was graded by the international grading criterion. The distributions of microaneurysms (MA), intraretinal hemorrhages/exudates (He/Ex), intraretinal microvascular abnormality (IRMA), capillary nonperfusion areas (NPA), and neovascularization (NV) were estimated by multiple logistic regression analyse based on nine-field FFA and FP images. Results In mild nonproliferative diabetic retinopathy (NPDR), the highest frequency of MA was found in the posterior pole (67.7%), followed by the inferior nasal (59.4%), and the nasal (55.4%) fields. In moderate NPDR, MA frequently distributed in the posterior pole (98.0%), nasal (97.0%), superior (96.0%), inferior nasal (94.9%), and inferior (92.9%) fields, whereas He/Ex were most prevalent in the posterior pole (69.7%). In severe NPDR and proliferative DR, IRMA, NPA, and NV were more frequent in the nasal field, particularly in the inferior nasal field (60.3, 38.7, and 76.0%, respectively). All lesions were more observed in the combined posterior pole, nasal, and inferior nasal fields than in the posterior pole or combined two fields in the early and severe stages of DR (P < 0.05). Conclusions The manifest lesions of DR were common in the nasal field besides the posterior pole in Chinese patients. A combined examination of the posterior pole, nasal, and inferior nasal mid-peripheral retina would help to detect different retinal lesions of DR. Trial registration ClinicalTrial. gov, NCT03528720. Registered 18 May 2018 - Retrospectively registered.

Analysis of quantitative correlations between microaneurysm, ischaemic index and new vessels in ultrawide-field fluorescein angiography images using automated software

2019 ◽  
pp. bjophthalmol-2018-313596 ◽  
Author(s):  
Gisung Son ◽  
Yoon Jeon Kim ◽  
Yu Sub Sung ◽  
Bumwoo Park ◽  
June-Gone Kim
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Proliferative Diabetic Retinopathy ◽  
Diabetic Macular Oedema ◽  
Posterior Pole ◽  
Peripheral Retina ◽  
Foveal Thickness ◽  
Central Foveal Thickness ◽  
Treatment Naïve ◽  
Automated Software

Background/AimTo analyse ultrawide-field fluorescein angiography (UWF-FA) images of diabetic retinopathy using a novel software that automatically calculates microaneurysm (MA) and non-perfusion area.MethodsTwo hundred UWF-FA images of treatment-naïve diabetic retinopathy (38 proliferative diabetic retinopathy and 162 non-proliferative diabetic retinopathy) from 120 patients (mean age 54.22; 80 male) were analysed using novel software to determine the number of MAs, area of capillary non-perfusion (ischaemic index) and number of neovascularisations. Each result was compared according to its retinal regions.ResultsFor the total retina, the mean number of MAs was 292.02 (±175.57) and the ischaemic index was 59.42% (±14.78%). Most MAs were located in the mid-peripheral retina (80.54%); however, the density of MAs was highest in the posterior pole (p<0.001). The ischaemic index was highest in the peripheral retina (89.19%), followed by mid-periphery (50.65%) and posterior pole (1.85%). Patients with diabetic macular oedema (DME) presented more MA and a greater ischaemic index (p<0.001, each) than those without DME.ConclusionThe automated software allowed prompt and quantitative analysis of UWF-FA images of DMR. MAs were most frequent in the nasal and mid-peripheral retina, with their density being highest in the posterior pole and nasal retina. Ischaemic index increased with distance from the posterior pole, showing strong correlation with central foveal thickness in all retinal areas except the posterior pole.

scholarly journals Comparison of fundus fluorescein angiography, optical coherence tomography and optical coherence tomography angiography features of macular changes in Eales disease: a case series

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ketaki Rajurkar ◽  
Meenakshi Thakar ◽  
Priyadarshi Gupta ◽  
Anju Rastogi
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Optical Coherence Tomography Angiography ◽  
Disease Process ◽  
Cystoid Macular Oedema ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Indirect Ophthalmoscopy ◽  
Eales Disease

Abstract Purpose To study the macular features in Eales disease patients observed with fundus fluorescein angiography (FA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods A cross-sectional study was done on treatment naïve 31 eyes (23 patients) with Eales disease. Baseline parameters such as Best-corrected visual acuity (BCVA), slit-lamp bio microscopy (SLB), indirect ophthalmoscopy, FA, spectral-domain OCT {quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT} and OCTA were performed. Any media opacity precluding the above investigations was excluded. Results Macular findings comprised of- epiretinal membrane, macular exudation, full thickness macular hole, sub internal limiting membrane bleed, cystoid macular oedema, neurosensory detachment and retinal thickening. Sixteen (51.6%) of our patients had macular changes as seen on all modalities together. SLB and indirect ophthalmoscopy missed macular findings in 50% patients and FA in 18.8% patients. OCT and OCTA diagnosed all macular findings. On comparison of mean BCVA in patients with macular involvement on FA, OCT and OCTA, compared to those without macular involvement, patients with macular involvement had lower BCVA (p 0.000, 0.01 and 0.001 respectively). Thus, FA missed many patients who had significant macular involvement and hence less vision. Conclusion Eales disease though described in literature as classically being peripheral retina disease process, also has macular involvement. OCT and OCTA are useful guides to evaluation of macular involvement in these patients. The latter seems to be superior to FA in detecting macular abnormalities in this ailment. OCTA is non-invasive and shows deep capillary plexus changes which are not shown by any other modality.

FLUORESCEIN ANGIOGRAPHY OF EXTREME PERIPHERAL RETINA AND RUBEOSIS IRIDIS IN PROLIFERATIVE DIABETIC RETINOPATHY

Retina ◽  
1999 ◽  
Vol 19 (4) ◽  
pp. 302-308 ◽  
Author(s):  
HIROKO TERASAKI ◽  
YOZO MIYAKE ◽  
MASAKO MORI ◽  
TOSHIMITU SUZUKI ◽  
MINEO KONDO
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Proliferative Diabetic Retinopathy ◽  
Peripheral Retina ◽  
Rubeosis Iridis

scholarly journals Probucol Prevents Diabetes-Induced Retinal Neuronal Degeneration through Upregulating Nrf2

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Heng-Wei Liu ◽  
Yong Luo ◽  
Yu-Fan Zhou ◽  
Zhong-Ping Chen
Keyword(s):  
Diabetic Retinopathy ◽  
Neuronal Degeneration ◽  
Fundus Photography ◽  
Control Group ◽  
Ros Generation ◽  
Fundus Fluorescein Angiography ◽  
Diabetic Retina ◽  
Nrf2 Signaling Pathway ◽  
Retinal Structure ◽  
Nrf2 Expression

Diabetic retinopathy (DR) is a sight-threatening complication of diabetes. This study investigated the therapeutic effect of probucol in a mouse model of diabetic retinopathy. C57BL/6 mice were rendered diabetic through Streptozotocin (STZ) intraperitoneal injection. Mice were treated with probucol (150 mg/kg, gavage administration) or vehicle (DMSO) for 12 weeks. Optical coherence tomography (OCT), fundus photography (FP), and fundus fluorescein angiography (FFA) were conducted to evaluate retinal structure and damage. Eyes were collected for histology, reactive oxygen species (ROS) assay, apoptotic cells count, and western blot. After STZ injection, all mice developed hyperglycemia. Compared with the retina of the control group, the retina of diabetic mice showed enhanced arterial reflex and beaded vein dilatation. Besides, reduced inner and middle retinal thickness and significantly fewer nuclei were found in diabetic retina. Moreover, the diabetic retina also presented increased ROS generation and more TUNEL-positive cells. Probucol treatment prevented diabetes-induced lesions. In addition, the treatment also upregulated Nrf2 expression in diabetic retina. It was suggested that probucol attenuated diabetes-induced retinal neuronal degeneration via upregulating the Nrf2 signaling pathway possibly. Probucol may be repurposed for DR management.

Medical retina

2012 ◽  
Author(s):  
Bheema Patil ◽  
Pankaj Puri
Keyword(s):  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Visual Loss ◽  
Clinical Skills ◽  
Night Vision ◽  
Age Related Macular Degeneration ◽  
Hypertensive Retinopathy ◽  
Fundus Fluorescein Angiography ◽  
Macular Lesion ◽  
Age Related

The chapter begins by discussing key clinical skills, namely fundus fluorescein angiography, abnormal fluorescein angiography, indocyanine green angiography, and electrophysiology. The following areas of clinical knowledge are then discussed: diabetic retinopathy, hypertensive retinopathy, retinal vein occlusion, retinal artery occlusions, age-related macular degeneration, intravitreal anti-VEGF injections, central serous chorioretinopathy, retinal vascular anomalies, retinal dystrophies, and choroidal dystrophies. The chapter concludes with eight case-based discussions, on gradual visual loss, central visual loss, visual loss in a hypertensive patient, sudden, painless visual loss, diabetic retinopathy, difficult night vision, visual loss in child, and macular lesion.

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