scholarly journals Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa

JCI Insight ◽  
2020 ◽  
Vol 5 (20) ◽  
Author(s):  
Laure Guenin-Macé ◽  
Jean-David Morel ◽  
Jean-Marc Doisne ◽  
Angèle Schiavo ◽  
Lysiane Boulet ◽  
...  
2020 ◽  
Author(s):  
Laure Guenin-Mace ◽  
Jean-David Morel ◽  
Jean-Marc Doisne ◽  
Angele Schiavo ◽  
Lysiane Boulet ◽  
...  

Hidradenitis Suppurativa (HS) is a chronic skin disorder of unknown etiology that manifests as recurrent, painful lesions. Cutaneous dysbiosis and unresolved inflammation are hallmarks of active HS, but their origin and interplay remain unclear. Our metabolomic profiling of HS skin revealed an abnormal induction of the kynurenine pathway (KP) of tryptophan catabolism in dermal fibroblasts correlating with the release of KP-inducing cytokines by inflammatory cell infiltrates. Notably, over-activation of the KP in lesional skin was associated with local and systemic depletion in tryptophan. Yet the skin microbiota normally degrades host tryptophan into indoles regulating tissue inflammation via engagement of the Aryl Hydrocarbon Receptor (AHR). In HS skin lesions, we detected contextual defects in AHR activation coinciding with impaired production of bacteria-derived AHR agonists and decreased incidence of AHR ligand-producing bacteria in the resident flora. Dysregulation of tryptophan catabolism at the skin-microbiota interface thus provides a mechanism linking the immunological and microbiological features of HS lesions. In addition to revealing metabolic alterations in HS patients, our study suggests that correcting AHR signaling would help restore immune homeostasis in HS skin.


2017 ◽  
Vol 97 (2) ◽  
pp. 208-213 ◽  
Author(s):  
H Ring ◽  
L Bay ◽  
K Kallenbach ◽  
I Miller ◽  
E Prens ◽  
...  

2020 ◽  
Vol 140 (4) ◽  
pp. 922-925.e3 ◽  
Author(s):  
Haley B. Naik ◽  
Jay-Hyun Jo ◽  
Maia Paul ◽  
Heidi H. Kong

2020 ◽  
Author(s):  
Ayako Masaki ◽  
Takashi Ishida ◽  
Maeda Yasuhiro ◽  
Asahi Ito ◽  
Susumu Suzuki ◽  
...  

2020 ◽  
Vol 99 (9) ◽  

Introduction: Perianal hidradenitis suppurativa is a chronic recurrent inflammatory, suppurative, and fistulising disease of apocrine glands, adjacent anal canal and soft tissues. Perianal area is the second most common affected area after axilla. There are three grades of the disease. Hidradenitis suppurativa represents a chronic, recurrent, deep-seated folliculitis resulting in abscesses, followed by the formation of sinus tracts and subsequent scarring. Perianal hidradenitis suppurativa is the last and the most serious grade of the disease and a specific access is needed for patient preparation and surgical treatment alone. The currently preferred method of treatment for patients with extensive perianal hidradentitis is excision and closure with combination of skin flaps, primary suture and skin graft in one or two stages. Case reports: There are three case reports of perianal hidradenitis suppurativa in this article. The local and overall initial treatment of patients followed by a radical excision and closure with a rotation skin flaps and skin grafts is described. The final results were satisfactory, with no recurrence or serious complication.


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