scholarly journals Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). Evidence for intermittent somatostatin secretion.

1985 ◽  
Vol 75 (5) ◽  
pp. 1584-1590 ◽  
Author(s):  
M L Vance ◽  
D L Kaiser ◽  
W S Evans ◽  
R Furlanetto ◽  
W Vale ◽  
...  
1987 ◽  
Vol 72 (2) ◽  
pp. 181-185 ◽  
Author(s):  
A. M. Sopwith ◽  
Elizabeth S. Penny ◽  
N. Lytras ◽  
G. M. Besser ◽  
Lesley H. Rees

1. Using a highly specific radioimmunoassay we have measured immunoreactive human growth hormone releasing factor (ir-hGRF) concentrations in the peripheral circulation of a total of 12 normal subjects. 2. Neither insulin-induced hypoglycaemia, intravenous arginine nor oral carbohydrate caused any change in venous plasma ir-hGRF concentrations, despite the expected stimulation and suppression respectively of growth hormone secretion. 3. Growth hormone secretion was not increased by oral fat or protein but each of these two foods stimulated ir-hGRF concentrations two- to fourfold. 4. Spontaneous pulses of growth hormone secretion on control days were unaccompanied by any increase in plasma ir-hGRF. 5. The dissociation between peripheral circulating ir-hGRF and growth hormone responses demonstrated under different circumstances suggests that an important source of human growth hormone releasing factor lies outside the hypothalamus and that secretion from this source is unconnected with the normal control of pituitary growth hormone secretion.


1985 ◽  
Vol 110 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Philippe Garry ◽  
Bernard Roussel ◽  
Richard Cohen ◽  
Sylviane Biot-Laporte ◽  
Abdel Elm Charfi ◽  
...  

Abstract. hGRF (iv 50 μg) was administered to 6 normal young adult males at 09.00 and 20.00 h on different days. Nocturnal GH secretion was monitored during polygraphic sleep recordings on both control nights and nights following hGRF administration. Sleep-related GH secretion and sleep parameters were not affected by diurnal hGRF administration.


1985 ◽  
Vol 56 (9) ◽  
pp. 744-750
Author(s):  
Koichi HODATE ◽  
Tetsu JOHKE ◽  
Asao KAWABATA ◽  
Hiroshi FUSE ◽  
Shinichi OHASHI ◽  
...  

1979 ◽  
Vol 4 (4) ◽  
pp. 341-349 ◽  
Author(s):  
Wallace B. Mendelson ◽  
Laurence S. Jacobs ◽  
J.Christian Gillin ◽  
Richard Jed Wyatt

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