Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis.

R Hohlfeld; K V Toyka; L L Miner; S L Walgrave; B M Conti-Tronconi

doi:10.1172/jci113369

Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis.

Journal of Clinical Investigation ◽

10.1172/jci113369 ◽

1988 ◽

Vol 81 (3) ◽

pp. 657-660 ◽

Cited By ~ 48

Author(s):

R Hohlfeld ◽

K V Toyka ◽

L L Miner ◽

S L Walgrave ◽

B M Conti-Tronconi

Keyword(s):

T Lymphocytes ◽

Myasthenia Gravis ◽

Nicotinic Receptor ◽

Alpha Subunit ◽

Receptor Alpha

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Stimulation of Autoimmune Helper T Lymphocytes from Patients with Myasthenia Gravis with Synthetic Peptides of the Acetylcholine Receptor Alpha Subunit

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1988.tb27154.x ◽

1988 ◽

Vol 540 (1 Advances in N) ◽

pp. 511-512 ◽

Cited By ~ 1

Author(s):

REINHARD HOHLFELD ◽

KLAUS V. TOYKA ◽

LUCINDA L. MINER ◽

BIANCA M. CONTI-TRONCONI

Keyword(s):

T Lymphocytes ◽

Myasthenia Gravis ◽

Acetylcholine Receptor ◽

Synthetic Peptides ◽

Alpha Subunit ◽

Receptor Alpha ◽

Helper T Lymphocytes ◽

Stimulation Of

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Stimulation of autoimmune helper T-lymphocytes from myasthenia gravis patients with synthetic peptides of the acetylcholine receptor alpha subunit

Journal of Neuroimmunology ◽

10.1016/0165-5728(87)90248-7 ◽

1987 ◽

Vol 16 (1) ◽

pp. 79

Author(s):

Reinhard Hohlfeld ◽

Klaus V. Toyka ◽

Bianca M. Conti-Tronconi

Keyword(s):

T Lymphocytes ◽

Myasthenia Gravis ◽

Acetylcholine Receptor ◽

Synthetic Peptides ◽

Alpha Subunit ◽

Receptor Alpha ◽

Helper T Lymphocytes ◽

Stimulation Of

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Immunodominant regions for T helper-cell sensitization on the human nicotinic receptor alpha subunit in myasthenia gravis.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.87.19.7792 ◽

1990 ◽

Vol 87 (19) ◽

pp. 7792-7796 ◽

Cited By ~ 46

Author(s):

M. P. Protti ◽

A. A. Manfredi ◽

C. Straub ◽

J. F. Howard ◽

B. M. Conti-Tronconi

Keyword(s):

Myasthenia Gravis ◽

Nicotinic Receptor ◽

T Helper Cell ◽

Alpha Subunit ◽

Helper Cell ◽

T Helper ◽

Receptor Alpha

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Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor alpha subunit.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.84.15.5379 ◽

1987 ◽

Vol 84 (15) ◽

pp. 5379-5383 ◽

Cited By ~ 64

Author(s):

R. Hohlfeld ◽

K. V. Toyka ◽

S. J. Tzartos ◽

W. Carson ◽

B. M. Conti-Tronconi

Keyword(s):

Myasthenia Gravis ◽

Nicotinic Receptor ◽

Alpha Subunit ◽

T Helper ◽

Receptor Alpha ◽

T Helper Lymphocytes

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Molecular mimicry and myasthenia gravis. An autoantigenic site of the acetylcholine receptor alpha-subunit that has biologic activity and reacts immunochemically with herpes simplex virus.

Journal of Clinical Investigation ◽

10.1172/jci114282 ◽

1989 ◽

Vol 84 (4) ◽

pp. 1174-1180 ◽

Cited By ~ 94

Author(s):

P L Schwimmbeck ◽

T Dyrberg ◽

D B Drachman ◽

M B Oldstone

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Myasthenia Gravis ◽

Acetylcholine Receptor ◽

Molecular Mimicry ◽

Alpha Subunit ◽

Receptor Alpha ◽

Biologic Activity ◽

Simplex Virus

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Acetylcholine Receptor Alpha Subunit mRNA Expression in Human Thymus: Augmented Expression in Myasthenia Gravis and Upregulation by Interferon-γ

Clinical Immunology ◽

10.1006/clim.1999.4689 ◽

1999 ◽

Vol 91 (2) ◽

pp. 170-177 ◽

Cited By ~ 20

Author(s):

Yi Zheng ◽

Lisa M. Wheatley ◽

Thomas Liu ◽

Arnold I. Levinson

Keyword(s):

Myasthenia Gravis ◽

Mrna Expression ◽

Acetylcholine Receptor ◽

Interferon Γ ◽

Alpha Subunit ◽

Receptor Alpha ◽

Subunit Mrna ◽

Human Thymus

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Human Muscle Acetylcholine Receptor Alpha-subunit Gene (CHRNA1) Association with Autoimmune Myasthenia Gravis in Black, Mixed-Ancestry and Caucasian Subjects

Journal of Autoimmunity ◽

10.1006/jaut.1996.0021 ◽

1996 ◽

Vol 9 (2) ◽

pp. 175-180 ◽

Cited By ~ 20

Author(s):

Jeannine M. Heckmann ◽

Karen E. Morrison ◽

Barbara Emeryk-Szajewska ◽

Halina Strugalska ◽

JoAnn Bergoffen ◽

...

Keyword(s):

Myasthenia Gravis ◽

Acetylcholine Receptor ◽

Human Muscle ◽

Alpha Subunit ◽

Subunit Gene ◽

Mixed Ancestry ◽

Receptor Alpha ◽

Autoimmune Myasthenia

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T-Cell Epitopes on the Human Acetylcholine Receptor alpha-Subunit Residues 10-84 in Myasthenia Gravis

Scandinavian Journal of Immunology ◽

10.1111/j.1365-3083.1992.tb02958.x ◽

1992 ◽

Vol 36 (3) ◽

pp. 435-442 ◽

Cited By ~ 6

Author(s):

R. AHLBERG ◽

Q. YI ◽

H. ENG ◽

R. PIRSKANEN ◽

A. K. LEFVERT

Keyword(s):

T Cell ◽

Myasthenia Gravis ◽

Acetylcholine Receptor ◽

Alpha Subunit ◽

T Cell Epitopes ◽

Receptor Alpha

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A mutation in the Muscle Nicotinic Receptor Alpha Subunit Leads to Slow Channel Syndrome Through Interaction with Gamma and Not the Epsilon Subunit

Biophysical Journal ◽

10.1016/j.bpj.2010.12.694 ◽

2011 ◽

Vol 100 (3) ◽

pp. 89a-90a

Author(s):

Michael Walogorsky ◽

Rebecca Mongeon ◽

Paul Brehm

Keyword(s):

Nicotinic Receptor ◽

Alpha Subunit ◽

Receptor Alpha ◽

Epsilon Subunit ◽

Slow Channel

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Peptide analogs to pathogenic epitopes of the human acetylcholine receptor alpha subunit as potential modulators of myasthenia gravis.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.93.9.4492 ◽

1996 ◽

Vol 93 (9) ◽

pp. 4492-4497 ◽

Cited By ~ 29

Author(s):

E. Zisman ◽

Y. Katz-Levy ◽

M. Dayan ◽

S. L. Kirshner ◽

M. Paas-Rozner ◽

...

Keyword(s):

Myasthenia Gravis ◽

Acetylcholine Receptor ◽

Alpha Subunit ◽

Receptor Alpha ◽

Peptide Analogs

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