scholarly journals Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility

2021 ◽  
Author(s):  
Tengfei Ma ◽  
Zhenbo Huang ◽  
Xueyi Xie ◽  
Yifeng Cheng ◽  
Xiaowen Zhuang ◽  
...  
Keyword(s):  
Cognitive Flexibility ◽  
Alcohol Drinking ◽  
Cholinergic Neurons ◽  
Chronic Alcohol

scholarly journals Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility

2021 ◽  
Author(s):  
Tengfei Ma ◽  
Zhenbo Huang ◽  
Xueyi Xie ◽  
Xiaowen Zhuang ◽  
Matthew Childs ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Cognitive Flexibility ◽  
Alcohol Drinking ◽  
Long Term Potentiation ◽  
D1 Receptor ◽  
Chronic Alcohol ◽  
Glutamatergic Transmission ◽  
Chronic Alcohol Consumption ◽  
Cholinergic Interneurons

Exposure to addictive substances impairs flexible decision-making. Cognitive flexibility is mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking alters cognitive flexibility through CINs remains unclear. Here, we report that chronic alcohol consumption and withdrawal impaired reversal of instrumental learning. Chronic alcohol consumption and withdrawal also caused a long-lasting (21 d) reduction of excitatory thalamic inputs onto CINs and reduced pause response of CINs in the dorsomedial striatum (DMS). CINs are known to inhibit glutamatergic transmission in dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) but facilitate this transmission in D2-MSNs, which may contribute to flexible behavior. We discovered that chronic alcohol drinking impaired CIN-mediated inhibition in D1-MSNs and facilitation in D2-MSNs. Importantly, in vivo optogenetic induction of long-term potentiation of thalamostriatal transmission in DMS CINs rescued alcohol-induced reversal learning deficits. These results demonstrate that chronic alcohol drinking reduces thalamic excitation of DMS CINs, compromising their regulation of glutamatergic transmission in MSNs, which may contribute to alcohol-induced impairment of cognitive flexibility. These findings provide a neural mechanism underlying inflexible drinking in alcohol use disorder.

scholarly journals Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates

eNeuro ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. ENEURO.0044-19.2019 ◽  
Author(s):  
Tatiana A. Shnitko ◽  
Zheng Liu ◽  
Xiaojie Wang ◽  
Kathleen A. Grant ◽  
Christopher D. Kroenke
Keyword(s):  
Young Adult ◽  
Brain Development ◽  
Alcohol Drinking ◽  
Nonhuman Primates ◽  
Adolescent And Young Adult ◽  
Chronic Alcohol

Profiling of extracellular vesicle‐bound miRNA to identify candidate biomarkers of chronic alcohol drinking in non‐human primates

2021 ◽  
Author(s):  
Sloan A. Lewis ◽  
Brianna Doratt ◽  
Suhas Sureshchandra ◽  
Tianyu Pan ◽  
Steven W. Gonzales ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Extracellular Vesicle ◽  
Chronic Alcohol

Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry

2021 ◽  
pp. 117-173
Author(s):  
C.A. Dannenhoffer ◽  
M.M. Robertson ◽  
Victoria A. Macht ◽  
S.M. Mooney ◽  
C.A. Boettiger ◽  
...  
Keyword(s):  
Cognitive Flexibility ◽  
Alcohol Exposure ◽  
Chronic Alcohol ◽  
Chronic Alcohol Exposure

Long-term changes of salivary exoglycosidases and their applicability as chronic alcohol-drinking and dependence markers

2017 ◽  
Vol 20 (1) ◽  
pp. 64-75 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Ewa Maria Kratz ◽  
Sylwia Chojnowska ◽  
Anna Zalewska ◽  
Krzysztof Zwierz ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Chronic Alcohol ◽  
Long Term Changes
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