Untreated Initial Psychosis: Relation to Cognitive Deficits and Brain Morphology in First-Episode Schizophrenia

The presence of cognitive deficits in schizophrenic illness has been extensively documented, and deficits in memory and executive functioning may be related to poor prognosis. Targeting these deficits during the early phase has potential benefits. The neural basis for cognitive deficits in schizophrenia is not well understood, and hence pharmacological interventions alone are insufficient. Future strategies should focus on pharmacological interventions combined with psychological techniques such as cognitive remediation. This review summarises recent findings relating to first-episode schizophrenia.

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Brain morphology in first-episode schizophrenia

American Journal of Psychiatry ◽

10.1176/ajp.152.12.1721 ◽

1995 ◽

Vol 152 (12) ◽

pp. 1721-1723 ◽

Cited By ~ 66

Keyword(s):

Brain Morphology ◽

First Episode ◽

First Episode Schizophrenia

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Brain morphology in first episode schizophrenia

Schizophrenia Research ◽

10.1016/0920-9964(91)90327-n ◽

1991 ◽

Vol 4 (3) ◽

pp. 387-388 ◽

Cited By ~ 1

Author(s):

J. Lieberman ◽

G. Degreef ◽

M. Ashtari ◽

B. Bogerts ◽

J. Alvir

Keyword(s):

Brain Morphology ◽

First Episode ◽

First Episode Schizophrenia

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Inflammatory Subtypes in Antipsychotic-Naïve First-Episode Schizophrenia are Associated with Altered Brain Morphology and Topological Organization

Brain Behavior and Immunity ◽

10.1016/j.bbi.2021.11.019 ◽

2021 ◽

Author(s):

Dung Hoang ◽

Yanxun Xu ◽

Olivia Lutz ◽

Deepthi Bannai ◽

Victor Zeng ◽

...

Keyword(s):

Brain Morphology ◽

First Episode ◽

Topological Organization ◽

First Episode Schizophrenia

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Brain morphometric comparison of first-episode schizophrenia and temporal lobe epilepsy

The British Journal of Psychiatry ◽

10.1192/bjp.170.6.515 ◽

1997 ◽

Vol 170 (6) ◽

pp. 515-519 ◽

Cited By ~ 27

Author(s):

W. B. Barr ◽

M. Ashtari ◽

R. M. Bilder ◽

G. Degreef ◽

J. A. Lieberman

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Hippocampal Formation ◽

Hippocampal Volume ◽

Brain Morphology ◽

First Episode ◽

Mr Images ◽

Significant Group ◽

Show Evidence ◽

First Episode Schizophrenia

BackgroundConverging evidence has suggested that the abnormalities in brain morphology observed in schizophrenia are similar to those seen in temporal lobe epilepsy (TLE). The purpose ofthis study was to compare the features of these groups directly with measures of the brain using magnetic resonance (MR) morphometry.MethodMorphometric measures of ventricular and hippocampal volumes obtained from FLASH MR images were studied in 32 patients with first-episode schizophrenia (FES), 39 patients withTLE (21 left, 18 right), and 42 healthy controls.ResultsVentricular volumes in the FES and TLE groups were both significantly larger than those seen in controls and did not differ from each other. The FES group showed significantly larger temporal horns, while theTLE group had relatively larger frontal horns. Analyses of hippocampal volumes revealed a significant group by hemisphere effect. The FES group showed relative reductions in left hippocampal volume that were comparable only toTLE patients with seizures originating from the left hemisphere.ConclusionThe results indicate that FES and TLE groups both show evidence of ventricular enlargement. Lateralised morphological abnormalities of the hippocampal formation in FES and left TLE are comparable, and may be specific to temporolimbic regions.

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