Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial

2021 ◽  
pp. appi.ajp.2020.2
Author(s):  
Sara Costi ◽  
Laurel S. Morris ◽  
Katherine A. Kirkwood ◽  
Megan Hoch ◽  
Morgan Corniquel ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Channel Opener ◽  
Reward Circuit

Efficacy And Central Mechanism of Acupuncture Treatment In Patients With Neck Pain: Study Protocol For A Randomized Controlled Trial

2021 ◽  
Author(s):  
Zhen Gao ◽  
Tao Yin ◽  
Lei Lan ◽  
Dehua Li ◽  
Ruirui Sun ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Neck Pain ◽  
Acupuncture Treatment ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Neck Disability Index ◽  
Pressure Pain Threshold ◽  
Central Mechanism ◽  
Cerebral Activity ◽  
Randomized Controlled

Abstract Background: Acupuncture is effective for reducing the symptoms of neck pain (NP). However, the underlying mechanisms are not fully elucidated. Based on evaluating the efficacy of two acupuncture prescriptions for treating NP. This study aims to investigate the potential central mechanism of acupuncture treatment for NP by functional magnetic resonance imaging (fMRI). Methods: This is a randomized controlled trial, 86 patients will be randomly assigned into two acupuncture treatment groups at a ratio of 1:1. The whole study period includes 2 weeks baseline, 2 weeks treatments and 12 weeks follow-up (4 and 12 weeks after treatment). The pain severity, the neck disability index, the cervical range of motion, the pressure pain threshold, etc. will be used to evaluate clinical efficacy of two acupuncture prescriptions for NP treatment. The MRI scans will be performed to detect cerebral activity changes of 20 patients in each group. The clinical data and MRI data will be analysed, respectively. Pearson correlation coefficient will be used to evaluate the association between changes of cerebral activity features and improvement of clinical symptoms.Discussion: The results might provide further evidence for the clinical application of acupuncture in the treatment of NP.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000040930. Registered on December 16, 2020.

scholarly journals Comparing the efficacy of 7%, 5% hypertonic saline and 0.9% normal saline in acute bronchiolitis: a randomized controlled trial

2018 ◽  
Vol 7 (5) ◽  
pp. 819
Author(s):  
Adel Ahadi ◽  
Manouchehr Barak ◽  
Fatemeh Amani
Keyword(s):  
Randomized Controlled Trial ◽  
Hypertonic Saline ◽  
Normal Saline ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Study Groups ◽  
Acute Bronchiolitis ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
The Mean

Background: The study aimed to investigate the effect of nebulized 5% and 7% Hypertonic Saline (HS) versus Normal Saline (NS) in acute viral bronchiolitis.Methods: This is a prospective, randomized controlled trial study that has been done on 90 infants presenting with acute bronchiolitis. All infants divided randomly in three equal size and matched groups (n=30). Subjects received 4ml nebulized 5% and 7% HS along with 0.15mg/kg Adrenaline or 4 ml 0.9%NS every 6 hours from enrolment until hospital discharge. For all patients, clinical symptoms such as sputum, wheezing, retraction rate, heart rate, fever, crackle, irritability, week nutrition and breathing were recorded in baseline and length of wheezing, cough, and crackle, length of stay (LOS), fever and sputum based on days in the end of study. Collected data analyzed by statistical methods in SPSS.19.Results: At baseline, study groups were similar in demographic and clinical characteristics. The mean age of all patients was 5.5±3.6 months, and 59 (65.6%) were male. The length of cough and crackle, and the length of LOS in 5% and 7% HS groups was significantly lower than NS group.Conclusions: Among infants admitted to the hospital with viral bronchiolitis, treatment with nebulized 5% HS and 7% HS had significant effect on decreasing clinical symptoms length and LOS when compared with NS.

scholarly journals Efficacy and central mechanism of acupuncture treatment in patients with neck pain: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Zhen Gao ◽  
Tao Yin ◽  
Lei Lan ◽  
Dehua Li ◽  
Ruirui Sun ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Neck Pain ◽  
Acupuncture Treatment ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Neck Disability Index ◽  
Pressure Pain Threshold ◽  
Central Mechanism ◽  
Cerebral Activity ◽  
Randomized Controlled

Abstract Background Acupuncture is effective for reducing the symptoms of neck pain (NP). However, the underlying mechanisms are not fully elucidated. Based on evaluating the efficacy of two acupuncture prescriptions for treating NP, this study aims to investigate the potential central mechanism of acupuncture treatment for NP by functional magnetic resonance imaging (fMRI). Methods This is a randomized controlled trial; 86 patients will be randomly assigned into two acupuncture treatment groups at a ratio of 1:1. The whole study period includes 2 weeks baseline, 2 weeks treatments, and 12 weeks follow-up (4 and 12 weeks after treatment). The pain severity, the neck disability index, the cervical range of motion, and the pressure pain threshold, etc., will be used to evaluate the clinical efficacy of two acupuncture prescriptions for NP treatment. The MRI scans will be performed to detect cerebral activity changes of 20 patients in each group. The clinical data and MRI data will be analyzed, respectively. Pearson correlation coefficient will be used to evaluate the association between changes of cerebral activity features and improvement of clinical symptoms. Discussion The results will provide further evidence for the clinical application of acupuncture in the treatment of NP. Trial registration Chinese Clinical Trial Registry ChiCTR2000040930. Registered on 16 December 2020.

scholarly journals Comparing the effect of sucrose gel and metronidazole gel in treatment of clinical symptoms of bacterial vaginosis: a randomized controlled trial

Trials ◽  
2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Somayyeh Khazaeian ◽  
Ali Navidian ◽  
Shahin-dokht Navabi-Rigi ◽  
Marzieh Araban ◽  
Faraz Mojab ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Bacterial Vaginosis ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals The Effect of Adjuvant Zinc Therapy on Recovery from Pneumonia in Hospitalized Children: A Double-Blind Randomized Controlled Trial

Scientifica ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Javad Qasemzadeh ◽  
Mahdi Fathi ◽  
Maryam Tashvighi ◽  
Mohammad Gharehbeglou ◽  
Soheila Yadollah-Damavandi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Healing Process ◽  
Hospitalized Children ◽  
Double Blind ◽  
Randomized Controlled ◽  
The Common ◽  
The Difference ◽  
Zinc Supplements

Objectives. Pneumonia is one of the common mortality causes in young children. Some studies have shown beneficial effect of zinc supplements on treatment of pneumonia. The present study aimed to investigate the effects of short courses of zinc administration on recovery from this disease in hospitalized children.Methods. In a parallel Double-Blind Randomized Controlled Trial at Ayatollah Golpaygani Hospital in Qom, 120 children aged 3–60 months with pneumonia were randomly assigned 1 : 1 to receive zinc or placebo (5 mL every 12 hours) along with the common antibiotic treatments until discharge. Primary outcome was recovery from pneumonia which included the incidence and resolving clinical symptoms and duration of hospitalization.Results. The difference between two groups in all clinical symptoms at admittance and the variables affecting the disease such as age and sex were not statistically significant (P<0.05) at baseline. Compared to the placebo group, the treatment group showed a statistically significant decrease in duration of clinical symptoms (P=0.044) and hospitalization (P=0.004).Conclusions. Supplemental administration of zinc can expedite the healing process and results in faster resolution of clinical symptoms in children with pneumonia. In general, zinc administration, along with common antibiotic treatments, is recommended in this group of children. It can also reduce the drug resistance caused by multiple antibiotic therapies. This trial is approved by Medical Ethic Committee of Islamic Azad University in Iran (ID Number: 8579622-Q). This study is also registered in AEARCTR (The American Economic Association's Registry for Randomized Controlled Trials). This trial is registered with RCT ID:AEARCTR-0000187.

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