Small Bowel Adenocarcinoma Complicating Crohn's Disease: Case Series and Review of the Literature

2007 ◽  
Vol 73 (11) ◽  
pp. 1181-1187 ◽  
Author(s):  
Lesly A. Dossett ◽  
Lisa M. White ◽  
Dereck C. Welch ◽  
Alan J. Herline ◽  
Roberta L. Muldoon ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
De Novo ◽  
Metastatic Cancer ◽  
Case Series ◽  
Small Bowel Adenocarcinoma ◽  
Review Of The Literature ◽  
Disease Case ◽  
History Of

Colonic adenocarcinoma frequently complicates inflammatory bowel disease of the colon, but small bowel adenocarcinoma (SBA) is a rare complication of Crohn's disease (CD). We present two patients with SBA in CD and review the literature with regards to CD-related SBA. A 45-year-old male with a 17-year history of ileal CD presented with obstructive symptoms but no radiographic evidence of a mass. After laparoscopic ileocolectomy and repair of incidental ileosigmoid fistula, pathology showed a T3N0 adenocarcinoma within the ileal CD. Two years after his resection he was without evidence of disease. A 59-year-old male with a 15-year history of CD presented with an acute exacerbation. Small bowel follow through demonstrated a long ileal stricture for which he underwent an ileocolic resection. Postoperative pathology confirmed a T3N1 CD-related SBA. He died from metastatic cancer 3 months later. Review of the literature identified 154 cases of SBA complicating CD with several distinguishing features from de novo SBA. Patients with SBA and CD are, as a group, younger and more likely to be male. SBA is rarely diagnosed preoperatively in these patients, and has a poor prognosis due to its advanced stage at diagnosis.

scholarly journals P106 Small bowel adenocarcinoma in the setting of Crohn's disease: systematic review of the literature

2019 ◽  
Vol 114 (1) ◽  
pp. S27-S28
Author(s):  
Aydinli H. Hande ◽  
Remzi Feza ◽  
Ream Justin ◽  
Galvao Neto Antonio L. ◽  
Megibow Alec J. ◽  
...  
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Small Bowel Adenocarcinoma ◽  
Review Of The Literature

Prognosis of small bowel adenocarcinoma in Crohn's disease compares favourably with de novo small bowel adenocarcinoma

2017 ◽  
Vol 19 (5) ◽  
pp. 446-455 ◽  
Author(s):  
N. Wieghard ◽  
S. Mongoue-Tchokote ◽  
J. I. Young ◽  
B. C. Sheppard ◽  
V. L. Tsikitis
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
De Novo ◽  
Small Bowel Adenocarcinoma

scholarly journals Small Bowel Adenocarcinoma in the Setting of Crohn’s Disease: A Systematic Review of the Literature

2020 ◽  
Vol 30 (4) ◽  
pp. 220-230
Author(s):  
Huriye Hande Aydınlı ◽  
Feza H. Remzi ◽  
David Schwartzberg ◽  
Justin Ream ◽  
Antonio Galvaoneto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Small Bowel Adenocarcinoma ◽  
Review Of The Literature

scholarly journals De novo distal terminal ileum adenocarcinoma mimicking Crohn’s disease and diagnostic challenges in imaging: a case series

2021 ◽  
pp. 20210103
Author(s):  
Dongwhee Lim ◽  
Suresh Fernando ◽  
Syed Hyder ◽  
Shalini Malhotra ◽  
Ahmad Miremadi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Terminal Ileum ◽  
De Novo ◽  
Case Series ◽  
Small Bowel Adenocarcinoma ◽  
Proper Diagnosis ◽  
Magnetic Resonance Imaging Mri ◽  
Conventional Ct

De novo small bowel adenocarcinoma (SBA) in the terminal ileum is the least common of the SBA types. However, its highest prevalence is found in the presence of Crohn’s disease (CD). As patients with SBA and CD present with similar symptoms, there is a high chance of misdiagnosing SBA as CD. This can lead to delay in proper diagnosis and can affect prognosis. In this article, we discuss two cases of de novo SBA mimicking CD, in the absence of CD, on conventional CT, CT enteroclysis and magnetic resonance imaging (MRI) enteroclysis. Moreover, it underlines the importance of suspecting SBA in cases where there is a lack of response to long-term medical treatment.

scholarly journals A Rare Case of Gastric Crohn’s Disease Complicated by Gastric Carcinoma

2018 ◽  
pp. 1-6
Author(s):  
Marwah Sami M Hussain ◽  
Bandar Idrees Ali ◽  
Abdullah Alzahrani
Keyword(s):  
Gastric Cancer ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Bowel Diseases ◽  
Rare Case ◽  
Small Bowel Adenocarcinoma ◽  
Disease Case ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Upper Gastrointestinal

Background: Inflammatory bowel diseases are strongly associated with colorectal cancer. In addition, a few cases reported with gastric and small bowel adenocarcinoma in gastroduodenal Crohn’s disease. Case report: We reported a case of a 47-Year-old female, who was referred to our surgical department and after a routine gastroscopy which revealed a lesion. Biopsy confirmed gastric well-differentiated adenocarcinoma of limited gastric Crohn’s disease, for a patient on regular anti Crohn’s medication. The patient underwent varying laparoscopic distal gastrectomy. She received adjuvant chemotherapy treatment and thereafter, she was cancer free within the period of 3- years of regular follow up. Conclusion: The only way to diagnose such lesions of a rare case of gastric cancer in a patient with Crohn’s disease is to regularly carry out upper gastrointestinal examinations. Keywords: Inflammatory bowel diseases, Crohn’s disease, Upper gastrointestinal tract Crohn’s disease, Gastric cancer

P108 TEDUGLUTIDE USE IN CROHN’S DISEASE: A CASE SERIES

2020 ◽  
Vol 26 (Supplement_1) ◽  
pp. S23-S23
Author(s):  
Adeeti Chiplunker ◽  
Christina Ha ◽  
Shirley Paski
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Median Duration ◽  
Dose Adjustment ◽  
Medical Center ◽  
Case Series ◽  
Dose Interval ◽  
Retrospective Case ◽  
Inflammatory Bowel

Abstract Background Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue with trophic effects on the intestinal mucosa to increase the absorptive surface area and enhance nutrient and fluid absorption of the small bowel (SB).1 It has been shown to reduce parenteral nutrition (PN) and intravenous fluid (IVF) requirements and is an important adjunct in the medical management of short bowel syndrome (SBS).1–2 Crohn’s disease (CD) is an important etiology of SBS but use of teduglutide in this population can be challenging. Aim The aim of this case series was to describe the use of teduglutide in CD patients. Methods A retrospective case series of all CD patients with SBS who used teduglutide at the Inflammatory Bowel Disease Center at Cedars-Sinai Medical Center. Age, duration of SBS, length of remaining SB and colonic continuity status were recorded. BMI, average daily PN kilocalories (kcal), and IVF requirements were recorded at the time of teduglutide initiation. The duration of teduglutide use was calculated. Teduglutide dose, dose adjustment history, reason for dose adjustment, and therapy complications were noted. Results 9 patients were included (5 male/4 female). Median age was 57 years (IQR 32). Median length of remaining small bowel was 60cm (IQR 27.5) and median duration of SBS was 8 years (IQR 9.83). Median BMI at teduglutide initiation was 18.66 (IQR 4.29) with a median duration of PN of 4.5 years (IQR 9.42) and median PN kcal/day of 971.43 (IQR 518). The median duration of teduglutide was 1.1 years (IQR 3.4). 4 patients (44%) had a teduglutide dose change. 2 patients had dose interval extended from daily to every other day to reduce injection burden. 1 patient developed obstructive symptoms on daily dosing, which resolved when the dose interval was extended to every other day. 1 patient had to stop therapy due to a small bowel obstruction requiring hospitalization. 8 patients (88%) were able to wean or stop PN/IVF with addition of teduglutide. 1 patient had to restart PN despite teduglutide therapy. Table 1. Discussion Teduglutide is effective in Crohn’s disease patients and facilitates weaning of PN and IVF requirements. Most patients tolerate the recommended dose with daily injections, but the dose interval can be extended to every other day to reduce obstructive symptoms or reduce the injection burden without affecting ability to wean PN/IVF. References

scholarly journals Precise Endoscopic and Pathologic Features in a Crohn's Disease Case with Two Fistula-associated Small Bowel Adenocarcinomas Complicated by an Anal Canal Adenocarcinoma

2013 ◽  
Vol 52 (4) ◽  
pp. 445-449 ◽  
Author(s):  
Mitsue Sogawa ◽  
Kenji Watanabe ◽  
Yutaro Egashira ◽  
Kiyoshi Maeda ◽  
Kenichi Morimoto ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Anal Canal ◽  
Pathologic Features ◽  
Disease Case
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