Severe Hyponatraemia Associated with Selective Serotonin Reuptake Inhibitors

1995 ◽  
Vol 40 (5) ◽  
pp. 147-148 ◽  
Author(s):  
I.C. Taylor ◽  
J.G. McConnell
Keyword(s):  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
The Elderly ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Major Advance ◽  
The Past ◽  
Specialist Referral ◽  
Severe Hyponatraemia ◽  
Treatment Of Depression

Depression in the elderly is a common problem, cited as occurring in up to 10% of elderly people living at home, half of whom may need specialist referral.1 The introduction of selective serotonin reuptake inhibitors has been reported as a major advance in the treatment of depression in that they are less sedating, have fewer anticholinergic effects and are less toxic in overdose.2 We report three cases of severe hyponatraemia, seen in the past 12 months, associated with the selective serotonin reuptake inhibitors fluoxetine and sertraline. Hyponatraemia has been reported as a rare adverse effect of selective serotonin reuptake inhibitors.3,4

Clinical comparison of selective serotonin reuptake inhibitors in the treatment of geriatric depression: a review of literature

2000 ◽  
Vol 10 (4) ◽  
pp. 349-373 ◽  
Author(s):  
Richard Marc Patel
Keyword(s):  
Side Effect ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Relevant Literature ◽  
The Elderly ◽  
The United States ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Geriatric Depression ◽  
First Choice

IntroductionWith their ease of administration, relatively benign side-effect profile and safety in overdose, in the United States the selective serotonin reuptake inhibitors (SSRIs) have become de facto first choice in the treatment of geriatric depression, displacing tricyclic antidepressants (TCAs). In this paper, the relevant literature regarding neurochemistry, kinetics, dosing, efficacy and differential side-effect profiles of citalopram, fluvoxamine, fluoxetine, sertraline, and paroxetine, the five currently available SSRIs in the USA, will be reviewed with special emphasis on geriatric data. Of late, considerable controversy has been generated regarding whether SSRIs are as effective as TCAs in severe and melancholic depressive subtypes. This important issue will be explored and the relative utility of all the SSRIs in the elderly patient compared and contrasted. Finally, reasons for difficulties in comparing results across studies will be elucidated.

Treatment of Depression in Acute Coronary Syndromes with Selective Serotonin Reuptake Inhibitors

Drugs ◽  
2006 ◽  
Vol 66 (16) ◽  
pp. 2095-2107 ◽  
Author(s):  
Joost P van Melle ◽  
Peter de Jonge ◽  
Maarten P van den Berg ◽  
Harm J Pot ◽  
Dirk J van Veldhuisen
Keyword(s):  
Serotonin Reuptake ◽  
Acute Coronary Syndromes ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Treatment Of Depression ◽  
Coronary Syndromes

The Impact of Trends in Psychotropic Prescribing on the Method of Suicide in the Elderly

2005 ◽  
Vol 45 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Ajit Shah ◽  
Lubbaba Lodhi
Keyword(s):  
Psychotropic Drugs ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
The Elderly ◽  
Serotonin Reuptake Inhibitors ◽  
Prescribing Patterns ◽  
Selective Serotonin ◽  
Hypnotics And Sedatives ◽  
Suicide Rates ◽  
Elderly Suicide

Suicide rates in the elderly have declined in many countries in recent years. This decline has been reported to be associated with increased prescribing of antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), antipsychotics and antimanic drugs and reduced prescribing of barbiturates, hypnotics and sedatives. This study examined the relationship between prescribing patterns of individual psychotropic drugs and suicide rates by specific methods of elderly suicides. There was a negative correlation between the prescription of tricyclic antidepressants, selective serotonin reuptake inhibitors, antipsychotics, antimanic drugs and non-opiate analgesics and a decline in elderly suicide rates due to poisoning by solid and liquid substances, hanging, strangulation and suffocation, drowning, firearms and explosives, and jumping from high places. There was a positive correlation between the prescription of barbiturates, hypnotics and sedatives and elderly suicide rates due to poisoning by solid and liquid substances, hanging, strangulation and suffocation, drowning, firearms and explosives, and jumping from high places. This study demonstrated that changes in prescribing patterns of individual psychotropic drugs do influence elderly suicide rates of the commonly used methods of suicide and suggest that this may be due to more accurate diagnostic-specific prescribing of psychotropic drugs.

Parturition in Anodonta cygnea induced by selective serotonin reuptake inhibitors (SSRIs)

2001 ◽  
Vol 79 (1) ◽  
pp. 95-100 ◽  
Author(s):  
E M Cunha ◽  
J Machado
Keyword(s):  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Freshwater Mussel ◽  
Transport Proteins ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Anodonta Cygnea ◽  
Treatment Of Depression ◽  
Freshwater Bivalves ◽  
Stimulation Of

The selective serotonin reuptake inhibitors (SSRIs) fluoxetine (Nodep) and fluvoxamine (Dumyrox) are drugs commonly prescribed for the treatment of depression in humans. They act to increase serotonin (5-hydroxytryptamine) neurotransmission by inhibiting reuptake transport proteins at synapses. A similar effect of SSRIs seems to occur naturally in one group of invertebrates, the molluscs. In this study the action of these drugs at different concentrations and under different conditions was tested in the freshwater mussel Anodonta cygnea. Fluoxetine was more potent than fluvoxamine, inducing an intense release of larvae (parturition) at a concentration of 1 × 10–6 M in the presence of light. The non-SSRI antidepressants trazodone (Triticum), mianserine (Tolvon), and L-5-hydroxytryptophan (Cincofarm), which are known to have different serotoninergic mechanisms, had a strong, no, and a weak effect, respectively, on larval parturiton in A. cygnea. These effects suggest that serotonin could be a normal and relevant mediator of larval parturition in A. cygnea. Other parallel visible signs due to incubation with SSRIs were an increase in the volume of the foot and gills through water uptake and stimulation of valve movements. These results indicate that incubation with SSRIs is potentially important in culturing the larvae of freshwater bivalves, since it facilitates control of the intensity and timing of larval parturition.

scholarly journals Patterns of Antidepressant Prescriptions for the Treatment of Depression: A Scoping Review

2020 ◽  
Author(s):  
Nirmal Raj Marasine ◽  
Sabina Sankhi ◽  
Rajendra Lamichhane ◽  
Nim Bahadur Dangi
Keyword(s):  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Antidepressant Drugs ◽  
Public Health Problem ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Tolerability Profile ◽  
High Morbidity ◽  
Global Public Health ◽  
Treatment Of Depression

Abstract Introduction: Depression is an important global public health problem due to its relatively high lifetime prevalence and significant disability caused by it. It is associated with functional impairment and high morbidity and mortality. Antidepressant medication is considered to be the best treatment option for depressionMethod: Literature searches (2000-2019) were performed using PubMed, HINARI and Google Scholar that analyze the pattern of prescription of antidepressants among the patients of depression. .Results: Females suffered from depression more than their male counterparts. Married people, housewives, lower income people, employees and highly educated people suffered more from depression. Selective Serotonin Reuptake Inhibitors (SSRI) like Sertraline, was found out to be the most preferred antidepressant among the depressive patients. Conclusion: Our Study suggested that out of five major antidepressant drugs being available for the treatment of depression, selective serotonin reuptake inhibitors are preferred over others because of their better side effect and tolerability profile.

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