Drug nanocrystals offer an attractive approach for improving the solubility and dissolution
rate of poorly soluble drugs which accounts for nearly 40 % newly discovered drug molecules. Both
methods for manufacturing drug nanocrystals have high industrial acceptability for being simple and
easy to scale which is evident from the number of approved products available in the market. Ability to
modify multiple aspects of dosage form like bioavailability, release pattern and dosage form requirement
along with flexibility in choosing final dosage form starting from the tablet, capsule, suspension to
parenteral one, have made nanocrystal technology one of the very promising and adaptable technology
for dosage form design.
In the current study, a fundamental approach is used to establish operation procedure, for a hand operated double cone blender. Initially, assuming for a potent drug, where in, the strength of the drug is very less in the final dosage form, a one percent concentration of potassium permanganate with respect to final one kilogram of blended powder using starch as diluent was planned. With a kind of geometric progression method, at a rate of 10 rotations per minute, the final outcome of the uniform distribution of the potassium permanganate was found to be for at least for fourteen hours of rotations, leading to concentration range of potassium permanganate 0.08 ± 0.025 mg per mg of final blended powder.
The effect of water on the solid state characteristics of pharmaceutical excipients: Molecular mechanisms, measurement techniques, and quality aspects of final dosage form
