The effect of water on the solid state characteristics of pharmaceutical excipients: Molecular mechanisms, measurement techniques, and quality aspects of final dosage form

Conclusions from previously reported articles have revealed that many commonly used pharmaceutical excipients, known to be pharmacologically inert, show effects on drug transporters and/or metabolic enzymes. Thus, the pharmacokinetics (absorption, distribution, metabolism and elimination) of active pharmaceutical ingredients are possibly altered because of their transport and metabolism modulation from the incorporated excipients. The aim of this review is to present studies on the interaction of various commonly-used excipients on pre-systemic metabolism by CYP450 enzymes. Excipients such as surfactants, polymers, fatty acids and solvents are discussed. Based on all the reported outcomes, the most potent inhibitors were found to be surfactants and the least effective were organic solvents. However, there are many factors that can influence the inhibition of CYP450, for instance type of excipient, concentration of excipient, type of CYP450 isoenzyme, incubation condition, etc. Such evidence will be very useful in dosage form design, so that the right formulation can be designed to maximize drug bioavailability, especially for poorly bioavailable drugs.

Download Full-text

Effect of water vapor content during the solid state synthesis of manganese-doped magnesium fluoro-germanate phosphor on its chemistry and photoluminescent properties

Optical Materials ◽

10.1016/j.optmat.2019.109572 ◽

2020 ◽

Vol 99 ◽

pp. 109572 ◽

Cited By ~ 1

Author(s):

Amjad Ali ◽

Liudmyla M. Chepyga ◽

Laraib Sarfraz Khanzada ◽

Andres Osvet ◽

Christoph J. Brabec ◽

...

Keyword(s):

Water Vapor ◽

Solid State ◽

Water Vapor Content ◽

Solid State Synthesis ◽

Effect Of Water

Download Full-text

Physicochemical Characterization of Cyclodextrin–Drug Interactions in the Solid State and the Effect of Water on These Interactions

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24319 ◽

2015 ◽

Vol 104 (3) ◽

pp. 942-954 ◽

Cited By ~ 18

Author(s):

Noriko Ogawa ◽

Chisato Takahashi ◽

Hiromitsu Yamamoto

Keyword(s):

Solid State ◽

Drug Interactions ◽

Physicochemical Characterization ◽

Effect Of Water

Download Full-text

Molecular Mechanisms in Smart Materials

MRS Bulletin ◽

10.1557/s0883769400033170 ◽

1997 ◽

Vol 22 (5) ◽

pp. 20-34 ◽

Cited By ~ 100

Author(s):

Robert E. Newnham

Keyword(s):

Solid State ◽

Smart Materials ◽

Molecular Mechanisms ◽

Ceramic Composites ◽

State University ◽

Fall Meeting ◽

Pennsylvania State University ◽

Distinguished Career ◽

Optical Applications

The following is an edited version of the David Turnbull Lectureship address, given by recipient Robert E. Newnham at the 1996 MRS Fall Meeting. Newnham received the lectureship for “pioneering the field of ceramic composites for electronic and optical applications, and in recognition of a distinguished career of guiding students, lecturing, and writing.” Newnham is the Alcoa Professor of Solid State Science at The Pennsylvania State University.

Download Full-text