scholarly journals Establishment of blending control for Hand operated Double Cone Blender

2018 ◽  
Vol 6 (2) ◽  
pp. 30-34
Author(s):  
Bayya Subba Rao ◽  
Anuroop Raveendran ◽  
Ratnakar Baki ◽  
Adithya Jinuka
Keyword(s):  
Uniform Distribution ◽  
Potassium Permanganate ◽  
Dosage Form ◽  
Double Cone ◽  
Geometric Progression ◽  
Blended Powder ◽  
Operation Procedure ◽  
Percent Concentration ◽  
Potent Drug ◽  
Final Dosage Form

In the current study, a fundamental approach is used to establish operation procedure, for a hand operated double cone blender.  Initially, assuming for a potent drug, where in, the strength of the drug is very less in the final dosage form, a one percent concentration of potassium permanganate with respect to final one kilogram of blended powder using starch as diluent was planned.  With a kind of geometric progression method, at a rate of 10 rotations per minute, the final outcome of the uniform distribution of the potassium permanganate was found to be for at least for fourteen hours of rotations, leading to concentration range of potassium permanganate 0.08 ± 0.025 mg per mg of final blended powder.

Drug Nanocrystals: A Comprehensive Review with Current Regulatory Guidelines

2020 ◽  
Vol 17 (6) ◽  
pp. 470-482
Author(s):  
Mori Dhaval ◽  
Jalpa Makwana ◽  
Ekta Sakariya ◽  
Kiran Dudhat
Keyword(s):  
Dissolution Rate ◽  
Dosage Form ◽  
Poorly Soluble Drugs ◽  
Comprehensive Review ◽  
Drug Molecules ◽  
Regulatory Guidelines ◽  
Poorly Soluble ◽  
Form Design ◽  
Capsule Suspension ◽  
Final Dosage Form

Drug nanocrystals offer an attractive approach for improving the solubility and dissolution rate of poorly soluble drugs which accounts for nearly 40 % newly discovered drug molecules. Both methods for manufacturing drug nanocrystals have high industrial acceptability for being simple and easy to scale which is evident from the number of approved products available in the market. Ability to modify multiple aspects of dosage form like bioavailability, release pattern and dosage form requirement along with flexibility in choosing final dosage form starting from the tablet, capsule, suspension to parenteral one, have made nanocrystal technology one of the very promising and adaptable technology for dosage form design.

scholarly journals Investigation of the travel depth of the disc colter and the conditions for its balance

2021 ◽  
Vol 262 ◽  
pp. 01022
Author(s):  
Vladislav Mishkhozhev ◽  
Aliy Gabaev ◽  
Anatoly Nam ◽  
Vyacheslav Dzuganov ◽  
Taymira Pazova
Keyword(s):  
Uniform Distribution ◽  
Soil Layer ◽  
Soil Surface ◽  
Second Phase ◽  
Machine Operation ◽  
Seed Material ◽  
Operation Procedure ◽  
The Stability

The seeding machine operation procedure consists of preparing the place where the seed should be placed, in placing the grain at a certain level below the soil surface in a certain order of arrangement and, finally, in the embedding – this work in large part falls on the share of the colter. The presented operation procedure of the seeder unit provides two main phases: reproduction of the maximum possible uniform feed of seed and its transporting to the colter; preparation of the groove, the required agrotechnical dimensions and distribution of seed material within it, followed by embedding them with soil. At the first phase of the seeding procedure, the issues of the outflow of seed material and its travel through the “seed tube - colter” system are relevant, and for the second phase, it is necessary to investigate the deformations of the soil layer reproduced by the colters, which is extremely necessary to select conditions that ensure uniform distribution of seed along the length and width of the row and at the desired depth. The article analyzes the investigation results by various authors devoted to the study of the stability of the depth of the opener stroke, its balance, and on their basis, analytical dependences are obtained.

Sign in / Sign up

Export Citation Format

Share Document