scholarly journals Long-Term Complications of Infection of the Female Genital Tract by Intracellular Sexually-Transmitted Microorganisms: A Review

1983 ◽  
Vol 76 (12) ◽  
pp. 1045-1049 ◽  
Author(s):  
M J Hare
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Sexually Transmitted ◽  
Female Genital

Late toxicity of brachytherapy after female genital tract tumors treated during childhood: Prospective evaluation with a long-term follow-up

2015 ◽  
Vol 117 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Antonin Levy ◽  
Helene Martelli ◽  
Chiraz Fayech ◽  
Veronique Minard-Colin ◽  
Isabelle Dumas ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Late Toxicity ◽  
Prospective Evaluation ◽  
Long Term Follow Up ◽  
Female Genital

scholarly journals Susceptibility of Chlamydia trachomatisto Chlorhexidine Gluconate Gel

1998 ◽  
Vol 42 (7) ◽  
pp. 1726-1730 ◽  
Author(s):  
M. F. Lampe ◽  
L. M. Ballweber ◽  
W. E. Stamm
Keyword(s):  
Sexually Transmitted Diseases ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Microtiter Plate ◽  
Chlorhexidine Gluconate ◽  
Sexually Transmitted ◽  
Cell Monolayers ◽  
Topical Antimicrobial ◽  
Female Genital

ABSTRACT To identify topical antimicrobial preparations which may be effective in preventing the transmission of sexually transmitted diseases, we examined the activity of chlorhexidine gluconate (CHG) against Chlamydia trachomatis. Chlamydial elementary bodies were incubated with dilutions of CHG gel for various times from 0 to 120 min. An aliquot of each dilution was further diluted and was inoculated onto McCoy cell monolayers in individual wells in a 96-well microtiter plate. The cultures were incubated for 48 h, and the chlamydial inclusions were stained and counted. CHG gel diluted fourfold (0.0625% CHG) killed C. trachomatis serovar D, and CHG gel diluted eightfold (0.0313% CHG) killed serovar F immediately upon exposure. CHG gel diluted 16-fold (0.0156% CHG) killed serovar D, and CHG gel diluted 32-fold (0.0078% CHG) killed serovar F after 120 min of exposure. Alteration of the pH over the range of from 4 to 8 did not significantly affect its activity. The addition of 10% whole human blood decreased the CHG gel activity at 0 min but had no significant effect after 120 min of exposure. We conclude that CHG gel may be effective topically against C. trachomatis at concentrations that can be used and under conditions that are found in the female genital tract and that further studies of its antimicrobial efficacy and toxicity in vivo are warranted.

scholarly journals Mucosal Immunity in the Female Genital Tract, HIV/AIDS

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Juliana Reis Machado ◽  
Marcos Vinícius da Silva ◽  
Camila Lourencini Cavellani ◽  
Marlene Antônia dos Reis ◽  
Maria Luiza Gonçalves dos Reis Monteiro ◽  
...  
Keyword(s):  
Mucosal Immunity ◽  
Genital Tract ◽  
Hiv Transmission ◽  
Female Genital Tract ◽  
Sexually Transmitted ◽  
Systemic Spread ◽  
Increased Risk ◽  
Relationship Of ◽  
Female Genital ◽  
Hiv Aids

Mucosal immunity consists of innate and adaptive immune responses which can be influenced by systemic immunity. Despite having been the subject of intensive studies, it is not fully elucidated what exactly occurs after HIV contact with the female genital tract mucosa. The sexual route is the main route of HIV transmission, with an increased risk of infection in women compared to men. Several characteristics of the female genital tract make it suitable for inoculation, establishment of infection, and systemic spread of the virus, which causes local changes that may favor the development of infections by other pathogens, often called sexually transmitted diseases (STDs). The relationship of these STDs with HIV infection has been widely studied. Here we review the characteristics of mucosal immunity of the female genital tract, its alterations due to HIV/AIDS, and the characteristics of coinfections between HIV/AIDS and the most prevalent STDs.

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