Reform of Education Services for Adolescents Through Digital Technology

The problem of HIV/AIDS cases affects the number of human resources in education such as teachers, administrators, principals who are reduced due to illness or death. Increasing cases of HIV/AIDS that spread among adolescents make the government pay more attention to the increase in these cases. Empirical facts found during the study show that one of the stakeholders in the world of education stated that learning about HIV/AIDS prevention has not been considered an urgent matter. The research is qualitative research using a descriptive approach based on the perspective of public policy. In this case, researchers have developed a basic health promotion system about HIV/AIDS and have been introduced to sufferers newly infected with HIV/AIDS. The results of studies in the city of Banjarmasin explored policy issues in education for the prevention of HIV/AIDS. Study findings assist policymakers in making decisions regarding HIV/AIDS prevention policies.

PENCEGAHAN PENULARAN PENYAKIT HIV/AIDS DARI IBU KE ANAK DI MASA PANDEMI COVID-19 MENUJU THREE ZERO 2030 DI DESA TELAGAWARU LOMBOK BARAT

ABSTRAKMengingat terjadinya peningkatan jumlah kejadian HIV/AIDS di Indonesia setiap tahunnya terdapat 9000 hamil HIV positif yang melahirkan diIndonesia. Sehingga diperhitungkan jika tidak ada intervensi maka akan ada 3000 bayi yang dilahirkan dengan HIV positif setiap tahunnya di Indonesia. Oleh karena itu perlu adanya intervensi yang baik untuk menurunkan resiko penularan HIV dari ibu ke anak sebesar 25%-45%. Tujuan dalam pengabdian masyarakat ini untuk mengetahui bagaimana penerimaan wanita atau ibu-ibu didesa telagawaru terhadap pelaksanaan PPIA saat ANC serta mengetahui seberapa besar pengetahuan yang dimiliki ibu-ibu tersebut tentang HIV/AIDS dari ibu ke anak. Metode yang digunakan dalam pengabdian ini terdapat 3 tahapan yaitu pretest, pemberian materi dan video serta posttest. Berdasarkan hasil pretest didapatkan pengetahuan ibu dalam kategori cukup (45,4%), setelah pemberian materi, posttest didapatkan pengetahuan ibu meningkat dalam kategori baik (89%). Pengetahuan yang dimiliki peserta dalam pengabdian ini sama seperti yang telah dikemukakan didalam teori yaitu pengetahuan dimana seseorang menjadi tahu terhadap suatu objek seperti halnya ibu yang telah mendapatkan informasi terbaru mengenai pencegahan penularan HIV dari ibu ke anak, sehingga peningkatan terhadap pengetahuanpun bertambah. Kata kunci: pencegahan HIV/AIDS; penularan HIV/AIDS; ibu hamil; janin. ABSTRACTDue to the increasing number of HIV/AIDS cases in Indonesia, every year there are 9000 HIV positive pregnant women born in Indonesia. Therefore, it is considered that if there is no intervention then there will be 3000 babies born with HIV positive every year in Indonesia. Therefore, it is necessary to have a good intervention to reduce HIV transmission from mother to child by 25%-45%. The purpose of this community service is to find out how the acceptance of women or mothers in the Telagawaru village towards the implementation of PPIA during ANC and to find out how much knowledge these mothers have about HIV/AIDS from mother to child. The method used in this service consists of 3 stages, namely pretest, giving materials and videos and posttest. Based on the results of the pretest, the mother's knowledge was in the sufficient category (45.4%), after giving the material, the posttest showed that the mother's knowledge increased in the good category (89%). The knowledge possessed by participants in this service is the same as what has been stated in theory, namely where a person's knowledge becomes aware of an object as well as mothers who have received the latest information about preventing HIV transmission from mother to child, so that the increase in knowledge increases. Keywords: prevention of HIV/AIDS; transmission of HIV/AIDS; pregnant women; fetus.

Modelling the geographical spread of HIV among MSM in Guangdong, China: a metapopulation model considering the impact of pre-exposure prophylaxis

Men who have sex with men (MSM) make up the majority of new human immunodeficiency virus (HIV) diagnoses among young people in China. Understanding HIV transmission dynamics among the MSM population is, therefore, crucial for the control and prevention of HIV infections, especially for some newly reported genotypes of HIV. This study presents a metapopulation model considering the impact of pre-exposure prophylaxis (PrEP) to investigate the geographical spread of a hypothetically new genotype of HIV among MSM in Guangdong, China. We use multiple data sources to construct this model to characterize the behavioural dynamics underlying the spread of HIV within and between 21 prefecture-level cities (i.e. Guangzhou, Shenzhen, Foshan, etc.) in Guangdong province: the online social network via a gay social networking app, the offline human mobility network via the Baidu mobility website, and self-reported sexual behaviours among MSM. Results show that PrEP initiation exponentially delays the occurrence of the virus for the rest of the cities transmitted from the initial outbreak city; hubs on the movement network, such as Guangzhou, Shenzhen, and Foshan are at a higher risk of ‘earliest’ exposure to the new HIV genotype; most cities acquire the virus directly from the initial outbreak city while others acquire the virus from cities that are not initial outbreak locations and have relatively high betweenness centralities, such as Guangzhou, Shenzhen and Shantou. This study provides insights in predicting the geographical spread of a new genotype of HIV among an MSM population from different regions and assessing the importance of prefecture-level cities in the control and prevention of HIV in Guangdong province. This article is part of the theme issue ‘Data science approach to infectious disease surveillance’.

A SWOT Analysis of the Guidelines on Prevention of HIV/AIDS in Japan in the Context of COVID-19

In January 2018, the Minister of Health, Labour and Welfare, Japan, released an amended Guideline on the Prevention of Specified Infectious Diseases on Acquired Immunodeficiency Syndrome (AIDS) to propose measures to control the human immunodeficiency virus (HIV)/AIDS. Content analysis was performed to examine the strengths, weaknesses, opportunities, and threats of the guidelines in the context of the ongoing COVID-19 pandemic, thus aiming to promote discussions on the guideline itself and the national HIV/AIDS strategy in Japan in the years ahead. The strengths included the incorporation of the latest scientific advancements, clarification of high-risk populations, an alignment with measures against sexually transmitted diseases (STDs), and willingness towards international cooperation in the Asia-Pacific region. The weaknesses that were exposed included a lack of explicit targets for controlling and containing HIV/AIDS, insufficient descriptions about pre-exposure prophylaxis (PrEP), and aggregated discussions on HIV/AIDS among foreign residents. Although several opportunities for re-energizing the discussions around HIV/AIDS were recognized, insufficient political will and funding, along with the emergence of the ongoing COVID-19 pandemic, could operate as threats. Addressing barriers that were recognized before 2019 and exposed due to the COVID-19 pandemic, and tackling underlying health inequalities through the concept of social determinants of health will be critical.

73. Interim Resistance Analysis of Long-Acting Lenacapavir in Treatment-Naïve People with HIV at 28 Weeks

Background Lenacapavir (LEN) is a first-in-class HIV-1 capsid (CA) inhibitor in clinical development for treatment and prevention of HIV-1 infection. CALIBRATE is an ongoing, phase 2 clinical study evaluating subcutaneous (SC) or oral LEN, in combination with other antiretrovirals, in treatment-naïve people with HIV-1. High rates of virologic success (HIV-1 RNA < 50 copies/mL) were achieved with LEN-based regimens by FDA Snapshot analysis at Week 28. Here, we present interim resistance analyses through Week 28. Methods Participants were randomized (2:2:2:1) to treatment groups (TG) (Figure): SC LEN + oral daily emtricitabine/tenofovir alafenamide (F/TAF); at Week 28, participants switch F/TAF to oral TAF (TG-A) or bictegravir (B, BIC) (TG-B); oral daily LEN + F/TAF (TG-C), or oral daily B/F/TAF (TG-D). Genotypic analyses (population sequencing) of HIV-1 reverse transcriptase and integrase, and genotypic (deep sequencing)/phenotypic analyses for CA were performed at screening; genotypic and phenotypic analyses were conducted at confirmed virologic failure. Figure CALIBRATE Study Design Results 182 participants were randomized and dosed in TG-A to D (n=52, 53, 52, 25). Most participants had subtype B HIV-1 (92.9%). Sequence analysis of baseline samples found 65% of amino acid residues were conserved with < 1% variation across CA overall, and 55% of residues were fully conserved. No mutations were detected at 6 positions in CA associated with reduced susceptibility to LEN in vitro; residues were fully conserved at 5 positions (L56, M66, Q67, K70, N74), and < 2% variation was observed at 1 position (T107). Three participants met the criteria for resistance analysis: 2 participants resuppressed to < 50 copies/mL while continuing treatment. One participant on SC LEN + F/TAF developed emergent resistance to LEN (Q67H+K70R) and emtricitabine (M184M/I), followed by resuppression after starting dolutegravir, zidovudine + lamivudine, tenofovir disoproxil fumarate. Conclusion Emergent resistance to LEN was uncommon in treatment-naïve participants receiving SC or oral LEN (0.6%, 1/157). These interim resistance findings support the ongoing evaluation of LEN for treatment and prevention of HIV. Disclosures Laurie VanderVeen, PhD, Gilead Sciences (Employee, Shareholder) Nicolas Margot, MA, Gilead Sciences (Employee, Shareholder) Vidula Naik, MSc, Gilead Sciences (Employee, Shareholder) Silvia Chang, Masters, Gilead Sciences, Inc (Employee, Shareholder) Ross Martin, PhD, Gilead Sciences, Inc (Employee, Shareholder) Hadas Dvory-Sobol, PhD, Gilead Sciences (Employee, Shareholder) Martin Rhee, MD, Gilead Sciences (Employee, Shareholder) Christian Callebaut, PhD, Gilead Sciences (Employee, Shareholder)

Effectiveness of Health Interventions towards HIV/AIDS in Developing Countries: A Systematic Review

Background: Plentiful development has been achieved in interventions for the prevention of HIV. Although, progression of prevention programs based on evidence – informed methods that interpret the effectiveness of these approaches in population is still a challenge. In developing countries, not many interventions are implemented for reduction of HIV burden. The single most important identified problem is lack of demand, supply, and adherence approaches. In current systemic review, recent evidence for the prevention of HIV in a cascade manner is described to see status of current interventions and further needs for improvements. Methodology: Systemic reviews regarding effectiveness on interventions of HIV prevention were searched. Primary studies were identified from eligible review that evaluated one of following factors: prevalence of HIV, incidence of HIV, testing uptake of HIV and use of condom. Interventions were categorized that pursued demand for prevention of HIV, improvement in supply for preventive approaches, support related to preventive behaviors or prevent HIV directly. A rating was assigned for each intervention based on evidence strength or randomized controlled trials. Results: Out of 91 eligible reviews, 264 primary studies were included in this review. Primary studies related to direct mechanisms of prevention that showed strong data for circumcision and effectiveness of pre – exposure prophylaxis. Evidence implies that interventions related to increased supply of preventive methods including clean needles or condoms can be operative. Interventions related to demand – side and adherence approaches were less clear with some studies showing effectiveness. Quality evidence was assessed among various categories. Various interventions showed supportive outcomes and results. In our findings, it was observed that difference between behavioral and structural has not evidently distinguished the interventions. Conclusion: Growing data is present for the support of effectiveness of products, behaviors, and procedures for prevention of HIV. In developing countries, negligible data is present for implementation of such approaches on community level. Interventions will be required for transforming this evidence to produce impact on population. It will empower the demand for prevention of HIV, supply of preventive technologies and utilization of preventive approaches against HIV. The findings can be eye opener to see actual burden of HIV and their implanted interventions and can be useful to design further intervention programs in future.

To study to Assess the Effectiveness of Planned Teaching on Knowledge and Attitude Regarding Transmission and Prevention of HIV/AIDS among Students of Junior Colleges

Introduction: HIV/AIDS is becoming a growing global danger to mankind. Since the first cases were reported, HIV/AIDS has been spreading at an alarming rate. Background: In India, The age group of 15-24 years accounts for 35% of all AIDS cases, indicating that the younger population is especially vulnerable to epidemics. Methods: The study was based on an interventional evaluatory approach and one group pretest-posttest design used. 60 junior college student samples were collected using Non-probability purposive sampling technique. one way ANOVA and t-test used to estimate the association between post-test knowledge and posttest attitude score transmission and prevention of HIV/AIDS among students of junior college the and the selected demographic variables. Results: This study revealed that the Mean value of the pretest knowledge score was 21.51 and the post-test knowledge score was 26.46 and the standard deviation of the pre-test knowledge score was ±4.96 and the post-test standard deviation was ±5.66. The t-value is 5.09 and the p-value is 0.0001. The mean value of the pretest attitude score was 28.48 and post-test attitude score was 40.25 and the standard deviation of the pre-test attitude score was ±4.13 and the post-test attitude score was ±2.45. The t- value is 18.98 and the p-value is 0.0001. There was a significant association of post-test knowledge score with the source of information about HIV/AIDS and there was no significant association of post-test attitude score regarding transmission and prevention of HIV/AIDS. Conclusion: The study concluded that planned teaching on knowledge and attitude regarding transmission and prevention of HIV/AIDS among students of junior college was effective as a teaching strategy.

Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

Given the suboptimal outcome of VRC01 antibody-mediated prevention of HIV-1 infection in its first field trial, means to improve diverse antiviral activities in vivo have renewed importance. This work revisits a loss-of-function experiment that investigated the mechanism of action of b12, a similar antibody, and finds that the reason why complement-mediated antiviral activities were not observed to contribute to protection may be the inherent lack of activity of wild-type b12, raising the prospect that this mechanism may contribute in the context of other HIV-specific antibodies.

HIV Knowledge Among Cisgender Female Sex Workers of Haitian Descent Working at the Border of Haiti and Dominican Republic

In this brief report, we aim to assess levels of HIV mis-information among cisgender Haitian female sex workers engaged in sex work at the Haiti and Dominican Republic border. We conducted bivariate analyses on the 2014 Border Study on Sex Workers comparing responses from female sex workers on the Haiti side of the border to those from their peers on the Dominican Republic side (N = 212). Prevention of HIV acquisition by correct and consistent condom use with each sex act was correctly endorsed by 90.5% of female sex workers in Haiti but only 57.0% of their peers in Dominican Republic (χ2 = 32.28, p < 0.001); 84.1% of respondents in Haiti correctly identified that HIV can be transmitted through a single unprotected sexual act, compared to 52.3% in Dominican Republic (χ2 = 25.2, p < 0.001). Significantly higher percentages of female sex workers in Dominican Republic correctly responded that HIV can be transmitted in pregnancy, compared to respondents in Haiti (96.5 vs. 71.4%; χ2 = 21.42, p < 0.001). Higher percentages of respondents in Dominican Republic correctly answered that HIV can be transmitted through needle sharing, relative to respondents in Haiti (100.0 vs. 89.7%; χ2 = 9.45, p < 0.01). Respondents in Dominican Republic more accurately rejected the possibility of transmission through food or through mosquito bites, compared to respondents in Haiti (95.4 vs. 81.8%, χ2 = 8.51, p < 0.01; 97.7 vs. 86.5%, χ2 = 7.81, p < 0.01, respectively). Findings indicate that if HIV knowledge is examined aggregating responses to individual questions, then elements of misinformation may remain unaddressed. For example, we found significant differences in correct answers ranging from 16.7 to 100.0%.