Basaloid Squamous Cell Carcinoma of the Larynx: Report of a Case

Basaloid squamous cell carcinoma is a variant of squamous cell carcinoma. This malignancy has a predilection for the upper aerodigestive tract, although it has been found in multiple other sites. The tumor is highly aggressive biologically, and the overall prognosis is poor despite intensive treatment. We describe a case of basaloid squamous cell carcinoma of the larynx that metastasized to the spine.

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Basaloid squamous cell carcinoma of the upper aerodigestive tract: a single squamous cell carcinoma subtype or two distinct entities hiding under one histologic pattern?

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-010-1443-4 ◽

2010 ◽

Vol 268 (2) ◽

pp. 161-164 ◽

Cited By ~ 8

Author(s):

Julia A. Woolgar ◽

James S. Lewis ◽

Kenneth O. Devaney ◽

Alessandra Rinaldo ◽

Hakan H. Coskun ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Aerodigestive Tract ◽

Basaloid Squamous Cell Carcinoma ◽

Upper Aerodigestive Tract ◽

Histologic Pattern ◽

Basaloid Squamous

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Basaloid Squamous Cell Carcinoma of the Upper Aerodigestive Tract

The Korean Journal of Pathology ◽

10.4132/koreanjpathol.2010.44.1.1 ◽

2010 ◽

Vol 44 (1) ◽

pp. 1 ◽

Cited By ~ 2

Author(s):

Kyung-Ja Cho

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Aerodigestive Tract ◽

Basaloid Squamous Cell Carcinoma ◽

Upper Aerodigestive Tract ◽

Basaloid Squamous

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Human papillomavirus–positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma

Human Pathology ◽

10.1016/j.humpath.2009.11.015 ◽

2010 ◽

Vol 41 (7) ◽

pp. 1016-1023 ◽

Cited By ~ 93

Author(s):

Rebecca D. Chernock ◽

James S. Lewis ◽

Qin Zhang ◽

Samir K. El-Mofty

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Cell Carcinoma ◽

Squamous Cell ◽

Molecular Subtype ◽

Squamous Cell Carcinomas ◽

Aerodigestive Tract ◽

Basaloid Squamous Cell Carcinoma ◽

Upper Aerodigestive Tract ◽

Basaloid Squamous

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Prognostic value of p27Kip1expression in Basaloid Squamous Cell Carcinoma of the larynx

BMC Cancer ◽

10.1186/1471-2407-6-146 ◽

2006 ◽

Vol 6 (1) ◽

Cited By ~ 13

Author(s):

Grazia Salerno ◽

Dolores Di Vizio ◽

Stefania Staibano ◽

Giampiero Mottola ◽

Giuseppe Quaremba ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Prognostic Value ◽

Basaloid Squamous Cell Carcinoma ◽

Carcinoma Of The Larynx ◽

Basaloid Squamous

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Basaloid Squamous Cell Carcinoma Occurring in the Urinary Bladder

Archives of Pathology & Laboratory Medicine ◽

10.5858/2000-124-0455-bsccoi ◽

2000 ◽

Vol 124 (3) ◽

pp. 455-459

Author(s):

Funda Vakar-López ◽

Jacki Abrams

Keyword(s):

Squamous Cell Carcinoma ◽

Urinary Bladder ◽

Cell Carcinoma ◽

Squamous Cell ◽

Squamous Metaplasia ◽

The Body ◽

Basaloid Squamous Cell Carcinoma ◽

Upper Aerodigestive Tract ◽

Tract Infections ◽

Basaloid Squamous

Abstract Basaloid squamous cell carcinoma is a recently described, distinct variant of squamous cell carcinoma that arises predominantly in the upper aerodigestive tract. Herein we report a case of basaloid squamous cell carcinoma arising in the urinary bladder. The patient was a 60-year-old woman who experienced intractable urinary tract infections following multiple corrective surgical procedures for incontinence. Biopsies of cystoscopically evident flat lesions were performed, and the patient subsequently underwent a radical cystectomy. Histologically, the lesions consisted of nests of basaloid cells with brisk mitotic activity, areas of squamous differentiation along with areas of squamous metaplasia, and squamous cell carcinoma in situ. These features are similar to those of basaloid squamous cell carcinoma described elsewhere in the body. To our knowledge, this is the first reported case of basaloid squamous cell carcinoma in the urinary bladder.

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Basaloid squamous cell carcinoma of the larynx: case report

ARS Medica Tomitana ◽

10.1515/arsm-2015-0016 ◽

2015 ◽

Vol 21 (1) ◽

pp. 27-31

Author(s):

Oana Cojocaru ◽

Mariana Aschie ◽

Luminita Gentiana Micu ◽

Gabriela Izabela Baltatescu ◽

Antonela Anca Nicolau

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Excisional Biopsy ◽

Basaloid Squamous Cell Carcinoma ◽

Upper Aerodigestive Tract ◽

Immunohistochemical Examination ◽

Ki 67 ◽

Epithelial Marker ◽

Basaloid Squamous

Abstract Basaloid squamous cell carcinoma is a rare variant of squamous cell carcinoma that most often occurs in the upper aerodigestive tract. This type of tumor has an aggressive behavior and usually is diagnosed in the advances stage. The diagnosis of basaloid squamous cell carcinoma is rather difficult and is based on histopathological and immunohistochemical examination. We report a case of laryngeal basaloid squamous cell carcinoma diagnosed by histological examination of a excisional biopsy specimen. The patient was a 57-year old female with a 3 months-history hoarseness and odynophagia. The histopathological aspect was strongly suggestive for BSCC. Immunohistochemical examination has been done using a panel of biomarkers in order to confirm our initial diagnose. The tumors nests were positive for squamous epithelial marker citokeratin 34βE12, AE1/AE3, CK 19 and also p53 and negative for carcinoembryonic antigen (CEA), vimentin and for neuroendocrine markers. Ki- 67 marker was positive in 60% of the tumoral cells. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as basaloid squamous cell carcinoma.

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