Recurrent Respiratory Papillomatosis With Complete Response to Systemic Bevacizumab Therapy

Recurrent respiratory papillomatosis is a condition caused by human papilloma virus, usually sub types 6 and 11. Papillomas are benign neoplasms that are most commonly found on the larynx and can be often associated with significant airway involvement. Frequency of episodes varies among patients as do the clinical symptoms. Patients often present with symptoms such as hoarseness but there is potential for respiratory compromise and even complete airway obstruction.

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SUCCESSFUL APPLICATION OF ARGON PLASMA COAGULATION AND INJECTION OF INTRALESIONAL CIDOFOVIR TO RELIEVE AIRWAY OBSTRUCTION CAUSED BY DIFFUSE INFECTION BY HUMAN PAPILLOMA VIRUS

CHEST Journal ◽

10.1378/chest.134.4_meetingabstracts.c24002 ◽

2008 ◽

Vol 134 (4) ◽

pp. 24C

Author(s):

Vichaya Arunthari ◽

Francisco G. Alvarez Aquino ◽

Cesar A. Keller ◽

Javier F. Aduen ◽

Amauri Rancier

Keyword(s):

Human Papilloma Virus ◽

Airway Obstruction ◽

Argon Plasma Coagulation ◽

Argon Plasma ◽

Papilloma Virus ◽

Plasma Coagulation

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2′,5′-Oligoadenylate synthetase activity analysis and human papilloma virus typing as prognostic factors in patients with recurrent respiratory papillomatosis

The Journal of Laryngology & Otology ◽

10.1258/0022215042450733 ◽

2004 ◽

Vol 118 (10) ◽

pp. 750-756 ◽

Cited By ~ 6

Author(s):

V. Gerein ◽

E. Rastorguev ◽

J. Gerein ◽

E. Lodemann ◽

H. Pfister ◽

...

Keyword(s):

Human Papilloma Virus ◽

Interferon Alpha ◽

Clinical Course ◽

Recurrent Respiratory Papillomatosis ◽

Synthetase Activity ◽

Oligoadenylate Synthetase ◽

Papilloma Virus ◽

Interferon Alpha Therapy ◽

Alpha Therapy

Objective: Determination of early prognostic factors in patients with recurrent respiratory papillomatosis is extremely important, so the major goal of our prospective, multicentre study was to evaluate (1) the feasibility of various factors to determine prognosis of the clinical course,as well as (2) the response to interferon-alpha therapy in recurrent respiratory papillomatosis. Methods: Forty-two patients with recurrent respiratory papillomatosis were treated with interferon-alpha (3 MU/m2 three times per week; mean therapy duration was 2.7 ± 1.8 years)in 1983–1994 and followed-up until 2003. Human papilloma virus (HPV) type, recurrent respiratory papillomatosis severity and 2′,5′-oligoadenylate synthetase activity were determined by standard methods and analysed for correlation with the results of long-term clinical outcome.Results and conclusion: Patients with HPV type 11, a severity score >4, a high number of surgical procedures prior to interferon-alpha therapy and a high basal 2′,5′-oligoadenylate synthetase activity should be considered at high risk of an aggressive clinical course, often with spread to lower airway passages, malignant transformation and death. Human papilloma virus type, score for recurrent respiratory papillomatosis severity, number of surgical procedures and 2′,5′-oligoadenylate synthetase activity showed significant association with response to interferon-alpha therapy and the long-term clinical course, so these factors have value in predicting prognosis in recurrent respiratory papillomatosis.

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Concurrent oral human papilloma virus infection in patients with recurrent respiratory papillomatosis: A preliminary study

The Laryngoscope ◽

10.1002/lary.24850 ◽

2014 ◽

Vol 124 (12) ◽

pp. 2785-2790 ◽

Cited By ~ 8

Author(s):

Hayley Born ◽

Ryan Ruiz ◽

Avanti Verma ◽

Salvatore Taliercio ◽

Stratos Achlatis ◽

...

Keyword(s):

Virus Infection ◽

Human Papilloma Virus ◽

Human Papilloma Virus Infection ◽

Recurrent Respiratory Papillomatosis ◽

Papilloma Virus ◽

Preliminary Study

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E1308: Reduced-dose IMRT in human papilloma virus (HPV)-associated resectable oropharyngeal squamous carcinomas (OPSCC) after clinical complete response (cCR) to induction chemotherapy (IC).

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.lba6006 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. LBA6006-LBA6006 ◽

Cited By ~ 7

Author(s):

Anthony Cmelak ◽

Shuli Li ◽

Shanthi Marur ◽

Weiqiang Zhao ◽

William H. Westra ◽

...

Keyword(s):

Human Papilloma Virus ◽

Induction Chemotherapy ◽

Complete Response ◽

Papilloma Virus ◽

Clinical Complete Response ◽

Reduced Dose

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Unexpected Upper Airway Obstruction Due to Disseminated Human Papilloma Virus Infection Involving the Pharynx in a Parturient

Acta Anaesthesiologica Taiwanica ◽

10.1016/s1875-4597(10)60019-7 ◽

2010 ◽

Vol 48 (2) ◽

pp. 87-90 ◽

Cited By ~ 1

Author(s):

Yuet Tong Ng ◽

Wai Meng Lau ◽

Tuan Jen Fang ◽

Jing Ru Hsieh ◽

Peter Chi Ho Chung

Keyword(s):

Virus Infection ◽

Human Papilloma Virus ◽

Airway Obstruction ◽

Upper Airway ◽

Human Papilloma Virus Infection ◽

Upper Airway Obstruction ◽

Papilloma Virus

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Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis

European Journal of Pediatrics ◽

10.1007/s00431-010-1174-y ◽

2010 ◽

Vol 169 (8) ◽

pp. 1017-1021 ◽

Cited By ~ 13

Author(s):

Ioannis N. Mammas ◽

George Sourvinos ◽

Elena Vakonaki ◽

Panagiota Giamarelou ◽

Catherine Michael ◽

...

Keyword(s):

Human Papilloma Virus ◽

Recurrent Respiratory Papillomatosis ◽

Papilloma Virus ◽

Hpv Genotypes

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Human Papilloma Virus – neonatal involvement

Ginecologia ro ◽

10.26416/gine.20.2.2018.1717 ◽

2018 ◽

Vol 20 (2) (1) ◽

pp. 60-63 ◽

Cited By ~ 1

Author(s):

Simona Popescu ◽

Andreea Mădălina Bănică ◽

Simona Vlădăreanu ◽

Radu Vlădăreanu

Keyword(s):

Human Papilloma Virus ◽

Pregnancy Outcomes ◽

Close Contact ◽

Paediatric Population ◽

Recurrent Respiratory Papillomatosis ◽

Quadrivalent Vaccine ◽

Sufficient Evidence ◽

Main Mode ◽

Papilloma Virus ◽

The Impact

Aims . Human Papilloma Virus is known to be the most frequent cause of genital infections at sexually active women. The virus is transmitted mainly sexually but epidemiological and clinical data suggest sufficient evidence also for other routes of transmission. Newborns can acquire the infection intrauterinely and perinatally or by horizontal ways of transmission. We aimed to describe, by reviewing the literature, the damaging effect of HPV on pregnancy outcomes and the risk of the newborn to develop recurrent respiratory papillomatosis. Also, we assessed the risk of HPV bivalent and quadrivalent vaccine in pregnancy and paediatric population. Method . We carried out an electronic database search, such as Pubmed, Medline, Google Scholar, for articles including “Human Papilloma Virus”, “perinatal transmission”, “recurrent respiratory papillomatosis”, “HPV vaccine”, “pregnancy outcomes”. We selected articles published between 2015 and 2018. Conclusions . The main mode of transmission from mother to newborn occurs during pregnancy and at the time of delivery. The virus can also be transmitted among the family members by close contact. There is insufficient data to conclude about the impact of Human Papilloma Virus on pregnancy and on the newborn, so for a relevant understanding more research for a long term and with an extended cohort is needed.

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