Dysbiosis of vaginal microbiota associated with persistent high-risk human papilloma virus infection

Background The status of vaginal microbiota in persistent high-risk human papilloma virus (HR-HPV) infection is unclear. The present work aimed to identify the vaginal microbiota of persistent HPV infection and explore the possible underlying microbiota factors. Methods A total of 100 women were recruited in this study, of which 28 presented HR-HPV persistent infection (P group), 30 showed clearance of any subtype of HR-HPV (C group), and 42 had no history of any HR-HPV infection (NC group). The vaginal microbiota and the community structure of the three groups were compared based on the 16S rRNA sequencing of the V3–V4 region. The microbiota diversity and differential analysis were carried out to detect the potential factors associated with HR-HPV infection. Results P and C groups showed an increase of Firmicutes and Actinobacteriota but a decrease in Proteobacteria compared to the NC group. The Chao1 index indicated that the microbial richness of the NC group was greater than C group (P < 0.05).The principal co-ordinate analysis(PCoA) revealed differences between the NC and P/C groups.The linear discriminant analysis effect size (LEfSe) method indicated that Proteobacteria phylum was significantly different in the mean relative abundance in the NC group,but the P and C groups did not show such indicative taxa. The Wilcox rank-sum test indicated that the Bifidobacterium (P = 0.002) and Lactobacillus (P = 0.005) of the C group were in a high mean relative abundance compared to the NC group. Conclusions The persistent HR-HPV infection is associated with dysbiosis of the vaginal microbiota. Microbiome regulation with Bifidobacteria and Lactobacillus may affect the clearance of HPV.

Effect of Health Education on Patients with Cervical Human Papilloma Virus Infection

Cervical HPV is an important factor leading to the occurrence of cervical cancer. Its occurrence and development is a gradual pathological change process, including high-risk HPV persistent infection, CIN, early invasive cancer and invasive cancer from quantitative to qualitative changes Continuous development process. At present, there is no good treatment for patients who have been infected with HPV. In order to enable HPV to achieve better prevention effects and postoperative rehabilitation effects, we have analyzed the application effects of health education in patients with cervical HPV infection to understand the importance of health education. Through a survey of patients who have undergone HPV treatment in hospitals in this city, the rehabilitation of patients who have adopted the same treatment method is compared. Experimental results prove that patients who have undergone the same treatment, but nave different levels of understanding of health education, have a great difference in their rehabilitation. Patients who understand health education are less than those who do not understand health education, and they receive treatment in patients. Later, patients who understand health education recover more than 40% faster than those who do not. This shows that health education plays an important role in the prevention and treatment of HPV, which can effectively prevent the occurrence of HPV, improve the postoperative rehabilitation effect of patients, and reduce postoperative risks.

The role of topic vaginal products as part of the therapeutic strategy in uterine cervix lesions

It has been widely demonstrated so far that lactobacilli represent probably the most important microorganisms which are developed at the level of the vaginal cavity and which are responsible for the maintenance of an adequate environment and pH at this level. Once the number of these microorganisms decrease the pH value increase leading to the apparition of a basic medium, which favors the development of certain microorganisms such as human papilloma virus. Meanwhile it is widely known that the presence of this virus is associated with an increased risk of developing premalignant and even malignant conditions. The aim of the current paper is to investigate the correlation between the vaginal pH, the risk of human papilloma virus infection and, in the meantime, to explore the possible benefits of local application of Cerviron, a topic, vaginal product which seems to significantly influence the risk of cervical lesions development.

Knowledge, Attitude and Practice of Main Stakeholders towards Human Papilloma Virus Infection and Vaccination in Mombasa and Tana-River Counties in Kenya: A Qualitative Study

Following a successful Human Papilloma Virus (HPV) vaccination pilot in 2013–2015 in Kitui county, Kenya introduced the HPV vaccine in October 2019 with a goal to immunize approximately 800,000 girls annually against HPV. Our study assessed the knowledge, attitudes, and practice of affected groups towards HPV infection and vaccination in two counties of Kenya. Semi-structured interviews from children aged between nine and thirteen years and key informants comprising of parents, head teachers, community leaders and health workers involved in HPV vaccination in health facilities from Mombasa and Tana-River counties were conducted. Content was analyzed thematically and coded for emerging themes using the QRS Nvivo 12 Plus software package. From our findings, a significant proportion of participants, especially children, have limited knowledge of the subject. Vaccination of boys was opposed by most participants. Parents and the community members are not in favor of HPV vaccination, as compared to the other groups. A similar pattern of inadequate knowledge and strongly opposed attitudes was observed in Tana-River and Mombasa. Active community involvement in primary prevention strategies may promote the uptake of the vaccine which can be achieved by robust awareness, modifying the negative beliefs about HPV vaccine and encouraging the perceptibility of HPV vaccination.

Risk Perception and Uptake of Human Papilloma Virus Vaccine among University Students in Jos, Plateau State

Background: Human papilloma virus is the most common sexually transmitted viral infection globally. It is a well-established cause of cervical cancer and about 75% of sexually active women and men will acquire this infection at some time in life. This study assessed the risk perception of human papilloma virus infection and its vaccine uptake among university students in Jos, Plateau State Nigeria. Methods: This was a cross-sectional survey conducted among 300 university students who were selected using a multistage sampling technique. A semi-structured interviewer administered questionnaire was used to assess risk perception and vaccine uptake. Data was analysed using Statistical Package for Social Sciences version 23. Associations between independent and dependent variables were determined using χ2 test while binary logistic regression was used to determine factors associated with risk perception, with significant value set at < 0.05. Results: Respondents’ awareness of human papilloma virus infection and the vaccine was 148 (49.3%) and 62(20.7%) respectively. Ninety four (31.3%) students had good risk perception of the infection while 206 (68.7%) had poor perception. Three (1.0%) students had taken the vaccine with no statistically significant difference between health and social science students (p = 0.05). Health science students had 3 times better risk perception than social science students (OR = 3.42, 95% CI = 2.03 - 5.77; P< 0.001). Conclusion: Human papilloma virus infection risk perception and vaccine uptake were poor among Jos University students. There is a need to improve the vaccine uptake through awareness creation and advocacy in Nigeria.