Acute Gastric Mucosal Lesions—A New Experimental Model and Effect of Parenteral Nutrition

1985 ◽  
Vol 9 (5) ◽  
pp. 571-582 ◽  
Author(s):  
Kimihiko Nakagawa ◽  
Akira Okada ◽  
Yasunaru Kawashima
Keyword(s):  
Parenteral Nutrition ◽  
Experimental Model ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

The Combination Therapy of Ephedra Herb and Loxoprofen Caused Gastric Lesions in Mice

2002 ◽  
Vol 30 (04) ◽  
pp. 571-577 ◽  
Author(s):  
Shigefumi Cho ◽  
Tie Hong ◽  
Guang-Bi Jin ◽  
Gen Yoshino ◽  
Myota Miura ◽  
...  
Keyword(s):  
Body Weight ◽  
Adverse Effects ◽  
Combination Therapy ◽  
Experimental Model ◽  
Common Cold ◽  
Gastric Lesions ◽  
Gastric Mucosal Lesions ◽  
Ephedra Herb ◽  
The Common ◽  
Mucosal Lesions

The combination therapy of a Kampo formula and an analgesic- antipyretic agent is often used for the common cold in Japan. We investigated the effect of such a combination therapy, using the Ephedra herb, which is a common ingredient of Kakkon-to and Mao-to, and Loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID), on fever induced in an experimental model of mice under strong stress. The combination therapy of Ephedra herb and Loxoprofen caused gastric mucosal lesions and loss of body weight. It is considered that this combination therapy should be avoided because of its adverse effects.

Resistance of mast cell-deficient W/Wv mice to H.pylori -associated gastric mucosal lesions

2001 ◽  
Vol 120 (5) ◽  
pp. A650-A650
Author(s):  
H SUZUKI ◽  
M MIYAZAWA ◽  
A KAI ◽  
S MIURA ◽  
H NAGATA ◽  
...  
Keyword(s):  
Mast Cell ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Protective Effect of Pyrus ussuriensis Maxim. Extract against Ethanol-Induced Gastritis in Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 439
Author(s):  
Naila Boby ◽  
Muhammad Aleem Abbas ◽  
Eon-Bee Lee ◽  
Zi-Eum Im ◽  
Walter H. Hsu ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Adenosine Monophosphate ◽  
Ethanol Ingestion ◽  
Dependent Manner ◽  
Protective Effects ◽  
Gastric Mucosal Lesions ◽  
Cellular Degeneration ◽  
Mucosal Lesions ◽  
Pyrus Ussuriensis Maxim

Pyrus ussuriensis Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine for asthma, cough, and atopic dermatitis in Korea and China. Although it was originally shown to possess anti-inflammatory, antioxidant, and antiatopic properties, its gastroprotective effects have not been investigated. In the present study, we evaluated the protective effects of Pyrus ussuriensis Maxim extract (PUE) against ethanol-induced gastritis in rats. The bioactive compound profile of PUE was determined by gas chromatography mass spectroscopy (GC-MS) and high-performance liquid chromatography (HPLC). The gastroprotection of PUE at different doses (250 and 500 mg/kg body weight) prior to ethanol ingestion was evaluated using an in vivo gastritis rat model. Several endpoints were evaluated, including gastric mucosal lesions, cellular degeneration, intracellular damage, and immunohistochemical localization of leucocyte common antigen. The gastric mucosal injury and ulcer score were determined by evaluating the inflamed gastric mucosa and by histological examination. To identify the mechanisms of gastroprotection by PUE, antisecretory action and plasma prostaglandin E2 (PGE2), gastric mucosal cyclic adenosine monophosphate (cAMP), and histamine levels were measured. PUE exhibited significant antioxidant effects with IC50 values of 56.18 and 22.49 µg/mL for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′- azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) inhibition (%), respectively. In addition, GC/MS and HPLC analyses revealed several bioactive compounds of PUE. Pretreatment with PUE significantly (P < 0.05) decreased the ulcer index by preventing gastric mucosal lesions, erosion, and cellular degeneration. An immunohistochemical analysis revealed that PUE markedly attenuated leucocyte infiltration in a dose-dependent manner. The enhancement of PGE2 levels and attenuation of cAMP levels along with the inhibition of histamine release following PUE pretreatment was associated with the cytoprotective and healing effects of PUE. In contrast, the downregulation of the H+/K+ ATPase pathway as well as muscarinic receptor (M3R) and histamine receptor (H2R) inhibition was also involved in the gastroprotective effects of PUE; however, the expression of cholecystokinin-2 receptors (CCK2R) was unchanged. Finally, no signs of toxicity were observed following PUE treatment. Based on our results, we conclude that PUE represents an effective therapeutic option to reduce the risk of gastritis and warrants further study.

scholarly journals Effects of intravenous lansoprazole on acute gastric mucosal lesions and acid secretion.

1996 ◽  
Vol 108 (6) ◽  
pp. 333-343 ◽  
Author(s):  
Nobuhiro INATOMI ◽  
Izumi MURAKAMI ◽  
Shoichi ASANO ◽  
Ikuko INADA ◽  
Hiroshi SATOH
Keyword(s):  
Acid Secretion ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions

2017 ◽  
Vol 53 (5) ◽  
pp. 618-630 ◽  
Author(s):  
Renata Czekaj ◽  
Jolanta Majka ◽  
Katarzyna Magierowska ◽  
Zbigniew Sliwowski ◽  
Marcin Magierowski ◽  
...  
Keyword(s):  
Gastric Mucosal Lesions ◽  
Mucosal Lesions
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