Different Effects of Long-Chain and Medium-Chain Triglycerides on Glucose Oxidation During Total Parenteral Nutrition

1992 ◽  
Vol 16 (5) ◽  
pp. 451-454 ◽  
Author(s):  
Nobuaki Sato ◽  
Youichi Matsubara ◽  
Keiji Yoshikawa ◽  
Terukazu Muto
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Glucose Oxidation ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Long Chain

Medium chain triglycerides in septic patients on total parenteral nutrition

1988 ◽  
Vol 7 (3) ◽  
pp. 157-163 ◽  
Author(s):  
A.C. Bach ◽  
M. Guiraud ◽  
J.P. Gibault ◽  
H. Schirardin ◽  
A. Frey ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Medium Chain Triglycerides ◽  
Medium Chain

Effects of D-beta-hydroxybutyrate and long- and medium-chain triglycerides on leucine metabolism in humans

1992 ◽  
Vol 262 (3) ◽  
pp. E268-E274 ◽  
Author(s):  
B. Beaufrere ◽  
D. Chassard ◽  
C. Broussolle ◽  
J. P. Riou ◽  
M. Beylot
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Parenteral Nutrition ◽  
Ketone Bodies ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Leucine Metabolism ◽  
Protein Sparing ◽  
Beta Hydroxybutyrate ◽  
Long Chain

Ketone bodies and/or fatty acids might play a protein-sparing role during prolonged fasting or parenteral nutrition. To assess this problem, we studied whole body leucine metabolism, using L-[1-13C]leucine in normal postabsorptive volunteers who received either long-chain triglycerides (LCT, 0.15 g.kg-1.h-1, 6 subjects), a 50-50 mixture of medium-chain triglycerides (MCT) and LCT (0.15 g.kg-1.h-1, 6 subjects), D-beta-hydroxybutyrate (540 mumol.kg-1.h-1, 6 subjects), or saline (4 subjects). Leucine concentration decreased only with MCT-LCT. Leucine flux decreased by 10-20% from basal in all groups. Leucine oxidation, which was corrected for the contribution to 13CO2 of the 13C natural abundance of the infused substrates, decreased during LCT infusion (0.31 +/- 0.02 to 0.24 +/- 0.01 mumol.kg-1.min-1, P less than 0.01), but was unaffected by MCT-LCT (despite plasma free fatty acid levels similar to those obtained with LCT), D-beta-hydroxybutyrate, or saline infusion. Therefore, 1) the effect of fatty acids on amino acid oxidation is not mediated by ketone bodies, 2) it depends on the fatty acid chain length, 3) long-chain fatty acids but not medium-chain fatty acids could play a protein-sparing role during parenteral nutrition.

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