This chapter provides the reader with a concise overview of the newest empirical evidences available on the use of assistive technology and cognitive behavioral interventions to promote adaptive skills and decrease challenging behaviors of children and adolescents with Rett syndrome and severe to profound developmental disabilities. Four main categories of studies were identified, namely (1) communication skills, (2) adaptive skills, (3) challenging behavior, and (4) on-task behavior. Twenty-six contributions were reviewed, and 936 participants were involved. Results were largely positive, although rare failures occurred. Educational, clinical, rehabilitative, and psychological implications of the findings were critically discussed. Some useful suggestions for future research and practice were emphasized.
