In the last six decades, the concept of mindfulness has been widely studied, researched, and practiced in mainstream psychology, mental health, and health disciplines. Over a period of time, clinical practitioners have integrated meditation and mindfulness practices or techniques in the mainstream psychological interventions for emotional and behavioral disorders such as anxiety, depression, chronic pain, borderline personality disorder, and eating disorder. This chapter highlights the application of Mindfulness-Based Interventions in various clinical and non-clinical samples. It also covers the importance of mindfulness practices for the crisis due to the COVID-19 pandemic, discusses integrating technology into mindfulness training, and presents various issues and challenges related to mindfulness practices.