scholarly journals Method development studies for repeatedly measuring anxiolytic drug effects in healthy humans

2009 ◽  
Vol 24 (5) ◽  
pp. 657-666 ◽  
Author(s):  
F. Klumpers ◽  
JM van Gerven ◽  
EPM Prinssen ◽  
I. Niklson Roche ◽  
F. Roesch ◽  
...  
Keyword(s):  
Method Development ◽  
Drug Effects ◽  
Development Studies ◽  
Anxiolytic Drug ◽  
Healthy Humans

scholarly journals Primary Tumor Culture and Method Development Studies of Patients with Lung Cancer

2019 ◽  
Vol 20 (-1) ◽  
pp. 36-36
Author(s):  
Demet Kahraman ◽  
◽  
Sedat Ilhan ◽  
Sibel Cangi ◽  
Ahmet Feridun Isik ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Tumor ◽  
Method Development ◽  
Development Studies

scholarly journals Cross-species anxiety tests in psychiatry: pitfalls and promises

2021 ◽  
Author(s):  
Dominik R. Bach
Keyword(s):  
Drug Screening ◽  
Healthy Human ◽  
Anxiolytic Drug ◽  
Healthy Humans ◽  
Potential Efficacy ◽  
The Social ◽  
Development Pipeline ◽  
Threat Avoidance ◽  
New Evidence ◽  
Independent Confirmation

AbstractBehavioural anxiety tests in non-human animals are used for anxiolytic drug discovery, and to investigate the neurobiology of threat avoidance. Over the past decade, several of them were translated to humans with three clinically relevant goals: to assess potential efficacy of candidate treatments in healthy humans; to develop diagnostic tests or biomarkers; and to elucidate the pathophysiology of anxiety disorders. In this review, we scrutinise these promises and compare seven anxiety tests that are validated across species: five approach-avoidance conflict tests, unpredictable shock anticipation, and the social intrusion test in children. Regarding the first goal, three tests appear suitable for anxiolytic drug screening in humans. However, they have not become part of the drug development pipeline and achieving this may require independent confirmation of predictive validity and cost-effectiveness. Secondly, two tests have shown potential to measure clinically relevant individual differences, but their psychometric properties, predictive value, and clinical applicability need to be clarified. Finally, cross-species research has not yet revealed new evidence that the physiology of healthy human behaviour in anxiety tests relates to the physiology of anxiety symptoms in patients. To summarise, cross-species anxiety tests could be rendered useful for drug screening and for development of diagnostic instruments. Using these tests for aetiology research in healthy humans or animals needs to be queried and may turn out to be unrealistic.

Multiple within-day conflict testing to define the time course of anxiolytic drug effects

1996 ◽  
Vol 53 (2) ◽  
pp. 369-377 ◽  
Author(s):  
Randall L. Commissaris ◽  
Zhongcong Xie ◽  
Paul J. Ninichuk ◽  
Victoria L. Markovska
Keyword(s):  
Time Course ◽  
Drug Effects ◽  
Anxiolytic Drug

scholarly journals Psychostimulant drug effects on glutamate, Glx, and creatine in the anterior cingulate cortex and subjective response in healthy humans

2018 ◽  
Vol 43 (7) ◽  
pp. 1498-1509 ◽  
Author(s):  
Tara L. White ◽  
Mollie A. Monnig ◽  
Edward G. Walsh ◽  
Adam Z. Nitenson ◽  
Ashley D. Harris ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Drug Effects ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Subjective Response ◽  
Healthy Humans

scholarly journals Experimental Studies of Anxiolytic Drug Effects on Heart Rate during Psychomotor Performance in Paired Situation

1975 ◽  
Vol 6 (4) ◽  
pp. 261-268
Author(s):  
Shigeyuki NAKANO ◽  
Nobuya OGAWA ◽  
Eiko OSATO ◽  
Hiroyuki UESAKA ◽  
Masashi GOTOO ◽  
...  
Keyword(s):  
Heart Rate ◽  
Psychomotor Performance ◽  
Experimental Studies ◽  
Drug Effects ◽  
Anxiolytic Drug

Neurochemical and behavioral sensitization to d-amphetamine in healthy subjects measured with [11C]-(+)-PHNO-PET

2016 ◽  
Vol 33 (S1) ◽  
pp. S105-S106
Author(s):  
A. Popovic ◽  
M. Bauer ◽  
L. Bartova ◽  
U. Sauerzopf ◽  
N. Praschak-Rieder ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Dopamine Release ◽  
Behavioral Sensitization ◽  
Drug Effects ◽  
Pet Scan ◽  
Binding Potential ◽  
Behavioral Measures ◽  
Healthy Humans ◽  
Competing Interest ◽  
Induced Changes

IntroductionIt has been shown that patients with schizophrenia are super-sensitive towards dopamine-releasing agents such as amphetamine. Here, we studied the effects of amphetamine sensitization on amphetamine-induced dopamine release in healthy subjects.ObjectivesTo measure d-amphetamine-induced dopamine release as measured with the D2,3 agonist radioligand [11C]-(+)-PHNO-PET via change in non-displacable binding potential (BPND) and behavioral measures of d-amphetamine effects with drug effects questionnaire (DEQ) and subjective states questionnaire (SSQ).AimsTo study d-amphetamine-induced sensitization in healthy subjects on a behavioral and neurochemical level with [11C]-(+)-PHNO-PET in order to gain more knowledge on sensitization-induced changes in the dopaminergic system.MethodsTwelve stimulant-naïve healthy male subjects underwent three 90-min [11C]-(+)-PHNO-PET-scans and four oral administrations of d-amphetamine. After a naïve baseline scan, subjects underwent a PET scan with previous ingestion of 0.4 mg/kg bodyweight of d-amphetamine 90–120 minutes before scanning. Subsequently, subjects were sensitized to d-amphetamine with the same dose on two separate days. Thereafter, they underwent another PET scan with previous d-amphetamine ingestion. DEQ and SSQ were administered before, 60 min, 90–120 min, and 210 min after amphetamine ingestion.ResultsWe found significant sensitization effects on a behavioral level and on a neurochemical level after four administrations of amphetamine. Items of the SSQ, which showed significant sensitization effects were “outgoing”, “energetic”, “lively”, “alert” and “focused”.ConclusionsWe were able to induce significant behavioral and neurochemical sensitization in healthy humans, which were measured with [11C]-(+)-PHNO-PET for the first time. This sensitization model will be useful for studying the neurobiology of schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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