Antidepressant treatments, including electroconvulsive shock and the putative antidepressant sibutramine hydrochloride, do not alter [3H]-prazosin binding to rat cortical membranes

1989 ◽  
Vol 3 (2) ◽  
pp. 70-75 ◽  
Author(s):  
K.F. Martin ◽  
I. Phillips ◽  
D.J. Heal ◽  
W.R. Buckett
Keyword(s):  
Electroconvulsive Shock ◽  
Antidepressant Treatments ◽  
Sibutramine Hydrochloride ◽  
Cortical Membranes

scholarly journals microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus

2013 ◽  
Vol 16 (8) ◽  
pp. 1885-1892 ◽  
Author(s):  
Richard M. O'Connor ◽  
Susan Grenham ◽  
Timothy G. Dinan ◽  
John F. Cryan
Keyword(s):  
Electroconvulsive Shock ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Shock Therapy ◽  
Contributory Factor ◽  
Sprague Dawley ◽  
Antidepressant Treatments ◽  
Sprague Dawley Rats ◽  
Antidepressant Action

Abstract Early-life stress is a main contributory factor to the onset of depression. Treatments remain inadequate and as such, a large unmet medical need for novel therapeutics remains. Impeding advancement is the poor understanding of the molecular pathology. microRNAs (miRNAs) are novel regulators of gene expression. A paucity of information regarding their role in depressive pathology and antidepressant action remains. This study investigated changes to hippocampal miRNA levels induced via early-life stress in Sprague–Dawley rats and whether antidepressant treatments could reverse these changes. Investigated were the selective serotonin reuptake inhibitor fluoxetine, the rapid acting N-methyl-d-aspartate receptor antagonist ketamine and electroconvulsive shock therapy (ECT). Microarray analysis revealed early-life stress affected the expression of multiple hippocampal miRNAs. Antidepressant treatments reversed some of these effects including a stress-induced change to miR-451. Ketamine and ECT possessed the highest number of common targets suggesting convergence on common pathways. Interestingly all three treatments possessed miR-598-5p as a common target. This demonstrates that changes to hippocampal miRNA expression may represent an important component of stress-induced pathology and antidepressant action may reverse these.

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