Health-related Quality of Life in Economic Evaluations for Osteoporosis

1999 ◽  
Vol 19 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Sherine E. Gabriel ◽  
Terry S. Kneeland ◽  
L. Joseph Melton ◽  
Megan M. Moncur ◽  
Bruce Ettinger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Economic Evaluations ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Burden of illness of hip fractures in elderly Dutch patients

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
T. A. Kanters ◽  
C. L. P. van de Ree ◽  
M. A. C. de Jongh ◽  
T. Gosens ◽  
L. Hakkaart-van Roijen
Keyword(s):  
Quality Of Life ◽  
Hip Fracture ◽  
Hip Fractures ◽  
Healthcare Costs ◽  
Burden Of Illness ◽  
Economic Evaluations ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Summary Patients with hip fractures experience reduced health-related quality of life and have a reduced life expectancy. Patients’ utilization of healthcare leads to costs to society. The results of the study can be used in future economic evaluations of treatments for hip fractures. Purpose Hip fractures are associated with high mortality, reduced quality of life, and increased healthcare utilization, leading to an economic burden to society. The purpose of this study is to determine the burden of illness of hip fractures in elderly Dutch patients for specific time periods after surgery. Methods Patients with a hip fracture above the age of 65 were included in the study. In the 1-year period after surgery, patients were asked to complete a set of questionnaires pre-injury (retrospectively), and 1 week, 1 month, 3 months, 6 months and 12 months after surgery. The set of questionnaires included the Euroqol 5D (EQ-5D-3L), the iMTA Medical Consumption Questionnaire (iMCQ) and iMTA Productivity Cost Questionnaire (iPCQ). Health-related quality of life was calculated using Dutch tariffs. Costs were calculated using the methodology described in the Dutch costing manual. Results Approximately 20% of patients with a hip fracture died within 1 year. Health-related quality of life was significantly reduced compared to pre-injury values, and patients did not recover to their pre-injury values within 1 year. Total costs in the first year after injury were €27,573, of which 10% were due to costs of the procedure (€2706). Total follow-up costs (€24,876) were predominantly consisting of healthcare costs. Monthly costs decreased over time. Conclusions Hip fractures lead to a burden to patients, resulting from mortality and health-related quality of life reductions, and to society, due to (healthcare) costs. The results of this study can be used in future economic evaluations.

scholarly journals Costs and Health-Related Quality of Life in Relation to Caries

2019 ◽  
Author(s):  
Lisa Kastenbom ◽  
Alexandra Falsen ◽  
Pernilla Larsson ◽  
Karin Sunnegårdh-Grönberg ◽  
Thomas Davidson
Keyword(s):  
Quality Of Life ◽  
Health Economic ◽  
Treatment Costs ◽  
Active Group ◽  
Economic Evaluations ◽  
Age Group ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Background Dental caries remains a common and expensive disease for both society and affected individuals. Furthermore, caries often affect individuals’ health-related quality of life (HRQoL). Health economic evaluations are needed to understand how to efficiently distribute dental care resources. This study aims to evaluate treatment costs and QALY weights for caries active and inactive adult individuals, and to test whether the generic instrument EQ-5D-5L can distinguish differences in this population. Methods A total of 1200 randomly selected individuals from dental clinics in Västerbotten County, Sweden, were invited to participate. Of these, 79 caries active and 179 caries inactive patients agreed to participate (response rate of 21.7%). Inclusion criteria were participants between 20-65 years old and same caries risk group categorization in two consecutive check-ups between 2014 and 2017. Results Treatment costs showed to be twice as high in the caries active group compared to the caries inactive group and were three times higher in the caries active age group 20-29 compared to the caries inactive age group 20-29. Differences between the groups was found for number of intact teeth according to age groups. In the EQ-5D-5L instrument, more problems relating to the dimension anxiety/depression was seen in the caries active group. QALY weights showed tendencies (non-significant) to be lower in the caries active group. Conclusions These findings highlight the need for efficient treatments and prevention strategies as well as adequate money allocation within dentistry. However, further research is needed to assess appropriate instruments for health economic evaluations.

scholarly journals German tariffs for the ICECAP-Supportive Care Measure (ICECAP-SCM) for use in economic evaluations at the end of life

2021 ◽  
Author(s):  
Judith Dams ◽  
Elisabeth Huynh ◽  
Steffi Riedel-Heller ◽  
Margrit Löbner ◽  
Christian Brettschneider ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Latent Class ◽  
Economic Evaluations ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Uk ◽  
Combined Data ◽  
Care Measure

Abstract Objectives Economic evaluations often use preference-based value sets (tariffs) for health-related quality of life to quantify health effects. For wellbeing at the end of life, issues beyond health-related quality of life may be important. Therefore, the ICECAP Supportive Care Measure (ICECAP-SCM), based on the capability approach, was developed. A validated German ICECAP-SCM version was published recently. However, tariffs for the German ICECAP-SCM are not available. Therefore, the aim was to determine tariffs for the ICECAP-SCM based on preferences of the German general population. Methods An online sample of 2996 participants completed a best–worst scaling (BWS) and a discrete choice experiment (DCE). BWSs required participants to choose the best and worst statement within the same capability state, whereas DCEs required participants to trade-off between two capability states. First, BWS and DCE data were analyzed separately. Subsequently, combined data were analyzed using scale-adjusted conditional logit latent class models. Models were selected based on the stability of solutions and the Bayesian information criterion. Results The two latent class model was identified to be optimal for the BWS, DCE, and combined data, and was used to derive tariffs for the ICECAP-SCM capability states. BWS data captured differences in ICECAP-SCM scale levels, whereas DCE data additionally explained interactions between the seven ICECAP-SCM attributes. Discussion The German ICECAP-SCM tariffs can be used in addition to health-related quality of life to quantify effectiveness in economic evaluations. The tariffs based on BWS data were similar for Germany and the UK, whereas the tariffs based on combined data varied. We would recommend to use tariffs based on combined data in German evaluations. However, only results on BWS data are comparable between Germany and the UK, so that tariffs based on BWS data should be used when comparing results between Germany and the UK.

scholarly journals Long-term health-related quality of life, survival and costs by different levels of functional outcome six months after stroke

2018 ◽  
Vol 3 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Ann-Sofie Rudberg ◽  
Eivind Berge ◽  
Anders Gustavsson ◽  
Per Näsman ◽  
Erik Lundström
Keyword(s):  
Quality Of Life ◽  
Functional Outcome ◽  
Economic Evaluations ◽  
Health Related Quality ◽  
Term Survival ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Introduction Information about the impact of functional outcome after stroke is currently missing on health-related quality of life, survival and costs. This information would be valuable for health economic evaluations and for allocation of resources in stroke health care. Patients and methods Data on 297 Swedish patients included in the Third International Stroke Trial were analysed including functional outcome at six months (measured by Oxford Handicap Scale), health-related quality of life up to 18 months (EQ-5D-3L) and survival up to 36 months. We used record linkage to collect data on costs up to 36 months, using national patient registers. Results Patients with a better functional outcome level at six months had a significantly better health-related quality of life at 18 months ( p < 0.05), better long-term survival ( p < 0.05) and lower costs ( p < 0.001), for all time points up to 36 months. The difference in costs was mainly due to differences in days spent in hospital ( p < 0.005). Discussion This study showed an association between functional outcome at six months and health-related quality of life up to 18 months, and costs up to 36 months. Conclusion Functional outcome six months after stroke is an important determinant of health-related quality of life, survival and costs over 36 months. Effective interventions aimed at reducing short-term disability levels are therefore also expected to reduce the overall burden of stroke.

Fit for the future? Status of health-related quality of life research in South Africa

2020 ◽  
Vol 36 (5) ◽  
pp. 508-517
Author(s):  
Sophia E. Marsh ◽  
Ilse Truter
Keyword(s):  
Quality Of Life ◽  
South Africa ◽  
South African ◽  
Assessment Process ◽  
Economic Evaluations ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Multiple Languages

ObjectiveTo provide insights into the attributes of health-related quality of life (HRQoL) research within the context of economic evaluations for a potential national health technology assessment process in South Africa, and make evidence generation recommendations.MethodsA systematic review was conducted in January 2019 using Medline, the Web of Science (WoS) Core Collection and the South African SciELO collection via the WoS Platform, and in the Cochrane Library. No time restrictions were applied. Duplicate records were removed before first- and second-pass screening by two reviewers working independently.ResultsThe review identified 123 publications representing 104 studies since the first-published article appeared in 1996. Only eight studies were randomized controlled trials, most were cross-sectional (n = 54). The EQ-5D, SF-36, and WHOQOL-BREF were the most used HRQoL instruments (n = 35, n = 23, and n = 10, respectively). Instruments were frequently administered in multiple languages, reflecting the cultural groups in which the study was conducted, with the English version of instruments used most often. Studies were predominantly conducted within the public health sector (n = 67), in the Western Cape province (n = 46), in adults (n = 92) and people with HIV (n = 24).ConclusionSouth African specific HRQoL studies have been conducted in a range of settings and populations using mostly generic HRQoL instruments in multiple languages. These studies may provide generalizable, real-world data due to their observational nature. However, more comparative and longitudinal studies should be conducted as this is preferred for economic evaluations and patient, disease, and treatment characteristics should be reported in full.

scholarly journals Social tariffs and democratic choice – do population-based health state values reflect the will of the people?

2019 ◽  
Author(s):  
Paul Schneider
Keyword(s):  
Quality Of Life ◽  
Future Research ◽  
Economic Evaluations ◽  
Health State ◽  
Health Related Quality ◽  
Health States ◽  
Health Technologies ◽  
Related Quality ◽  
Health Related

In economic evaluations of health technologies, health outcomes are commonly measured in terms of QALYs. QALYs are the product of time and health-related quality of life. Health-related quality of life, in turn, is determined by a social tariff, which is supposed to reflect the public’s preference over health states. This paper argues that, because of the tariff’s role in the societal decision making process, it should not be understood as merely a statistical model, but as a major instrument of democratic participation. I outline what implications this might have for both the method used to aggregate individual preferences, and the set of individuals whose preferences should count. Alternative tariff specifications are explored, and future research directions are proposed.

scholarly journals Developing a preference-based measure for weight-specific health-related quality of life in adolescence: the WAItE UK valuation study protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e054203
Author(s):  
Tomos Robinson ◽  
Sarah Hill ◽  
Yemi Oluboyede
Keyword(s):  
Quality Of Life ◽  
Economic Evaluation ◽  
Economic Evaluations ◽  
Health Related Quality ◽  
Health States ◽  
Related Quality ◽  
Health Related ◽  
The Uk ◽  
Specific Health

IntroductionAdolescent obesity is a public health problem in the UK. The Weight-Specific Adolescent Instrument for Economic Evaluation (WAItE) has been developed as the first weight-specific health-related quality of life measure appropriate for economic evaluation, but currently cannot be used to generate quality-adjusted life years (QALYs), which are the basis of cost-utility analysis. Generic measures (such as the EQ-5D-Y or CHU-9D) may be insensitive to small but important health changes in overweight or obese adolescents. This study aims to generate a preference-based scoring algorithm for the WAItE.Methods and analysisA discrete choice experiment (DCE) will be administered to value health states described by the WAItE classification system. These health states will be presented to members of the adult general population of the UK via an online survey. A range of regression models will be used to produce the utility algorithm for the WAItE. The DCE-visual analogue scale and time trade-off (TTO) anchoring methods will be used anchor the value set on to the 0–1 QALY scale.Ethics and disseminationThe Newcastle University Medical School Ethics Committee approved the study (references 4772/2020 (DCE) and 9978/2020 (TTO)). The developed algorithm can be applied to future economic evaluations of weight management interventions and treatments for adolescents.

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