Vertebral bone marrow fat content in normal adults with varying bone densities at 3T magnetic resonance imaging

2018 ◽  
Vol 60 (4) ◽  
pp. 509-515 ◽  
Author(s):  
Jie He ◽  
Hao Fang ◽  
Xiaona Li
Keyword(s):  
Bone Marrow ◽  
Bone Density ◽  
Inverse Association ◽  
Mineral Density ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Normal Bone ◽  
Vertebral Bone Marrow ◽  
Normal Adults

Background Sex-related differences of vertebral bone marrow fat in relation to varying bone densities have not yet been evaluated although some studies have reported an inverse association of bone marrow fat and bone mineral density (BMD). Purpose To evaluate the relationship between bone marrow fat and BMD and to demonstrate the sex-related differences of the vertebral bone marrow fat in normal adults with varying bone densities. Material and Methods A total of 123 normal adult volunteers were enrolled in this study. 1H-MRS of the lumbar spine was performed. The fat fraction (FF) values of vertebral bone marrow were measured. Volumetric BMD measurement was performed by quantitative computed tomography (QCT). All participants were divided into three groups according to BMD (normal, osteopenia, osteoporosis). The differences in the FF and body mass index (BMI) values of the three groups were compared, and partial correlation analysis was used to evaluate the correlation between FF values and BMD/BMI. Results The FF values increased with decreasing BMD in both male and female participants. There were significant sex differences for the FF values in the normal bone density group ( P < 0.001). The FF values of the normal bone density group in male participants were significantly higher than those of the female participants ( P < 0.001). The FF values were significantly negative correlated with BMD for all participants (r = −0.820, P < 0.001). Conclusion The FF values of vertebral bone marrow correlated inversely with BMD. Sex-related differences of FF values was related to BMD.

Vertebral bone marrow diffusivity in normal adults with varying bone densities at 3T diffusion-weighted imaging

2017 ◽  
Vol 59 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Jie He ◽  
Hao Fang ◽  
Xiao na Li
Keyword(s):  
Bone Marrow ◽  
Bone Density ◽  
Diffusion Weighted Imaging ◽  
Mineral Density ◽  
Vertebral Bone ◽  
Normal Bone ◽  
Diffusion Weighted ◽  
Adc Values ◽  
Vertebral Bone Marrow ◽  
Normal Adults

Background There has been controversy surrounding the relationship between diffusivity and bone mineral density (BMD) in vertebral bone marrow. Moreover, sex-related differences of vertebral bone marrow diffusivity in relation to varying bone densities have not yet been evaluated. Purpose To prospectively investigate the role of diffusion-weighted imaging (DWI) in assessing vertebral marrow changes in normal adults with varying bone densities. Material and Methods A total of 124 normal adult volunteers were enrolled in this study. Sagittal magnetic resonance (MR) DWI of the lumbar spine was performed. The ADC values of vertebral bone marrow were measured. Volumetric BMD measurement was performed by quantitative computed tomography (QCT) using Mindways QCT analysis software. All participants were divided into three groups according to BMD (normal, osteopenia, osteoporosis). The differences of the apparent diffusion coefficient (ADC) values of the three groups was compared, and partial correlation analysis was used to evaluate the correlation between ADC values and BMD. Results ADC values decreased as BMD decreased in female participants. When compared with the normal bone density group, ADC values were significantly decreased in the osteoporotic group and in the osteopenic group of female participants. ADC values of female participants were significantly higher than of male participants in the normal bone density group ( P < 0.001). ADC values correlated positively with BMD values (r = 0.307, P = 0.016) for female participants. Conclusion The diffusivity in vertebral bone marrow with varying bone densities differed by sex. ADC values correlated positively with BMD in women. DWI can quantitively evaluate osteoporosis in women.

scholarly journals Vertebral bone marrow fat, bone mineral density and diabetes: The Osteoporotic Fractures in Men (MrOS) study

Bone ◽  
2017 ◽  
Vol 97 ◽  
pp. 299-305 ◽  
Author(s):  
Yahtyng Sheu ◽  
Francesca Amati ◽  
Ann V. Schwartz ◽  
Michelle E. Danielson ◽  
Xiaojuan Li ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Marrow ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Mineral Density ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Vertebral Bone Marrow

The need forT2correction on MRS-based vertebral bone marrow fat quantification: implications for bone marrow fat fraction age dependence

2015 ◽  
Vol 28 (4) ◽  
pp. 432-439 ◽  
Author(s):  
Michael Dieckmeyer ◽  
Stefan Ruschke ◽  
Christian Cordes ◽  
Samuel P. Yap ◽  
Hendrik Kooijman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Age Dependence ◽  
Marrow Fat ◽  
Fat Quantification ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Fat Fraction ◽  
Vertebral Bone Marrow

scholarly journals Vertebral bone marrow fat fraction changes in postmenopausal women with breast cancer receiving combined aromatase inhibitor and bisphosphonate therapy

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Michael Dieckmeyer ◽  
Stefan Ruschke ◽  
Alexander Rohrmeier ◽  
Jan Syväri ◽  
Ingo Einspieler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Significant Difference ◽  
Fat Fraction ◽  
Vertebral Bone Marrow

Abstract Background Quantification of vertebral bone marrow (VBM) water–fat composition has been proposed as advanced imaging biomarker for osteoporosis. Estrogen deficiency is the primary reason for trabecular bone loss in postmenopausal women. By reducing estrogen levels aromatase inhibitors (AI) as part of breast cancer therapy promote bone loss. Bisphosphonates (BP) are recommended to counteract this adverse drug effect. The purpose of our study was to quantify VBM proton density fat fraction (PDFF) changes at the lumbar spine using chemical shift encoding-based water-fat MRI (CSE-MRI) and bone mineral density (BMD) changes using dual energy X-ray absorptiometry (DXA) related to AI and BP treatment over a 12-month period. Methods Twenty seven postmenopausal breast cancer patients receiving AI therapy were recruited for this study. 22 subjects completed the 12-month study. 14 subjects received AI and BP (AI+BP), 8 subjects received AI without BP (AI-BP). All subjects underwent 3 T MRI. An eight-echo 3D spoiled gradient-echo sequence was used for CSE-based water-fat separation at the lumbar spine to generate PDFF maps. After manual segmentation of the vertebral bodies L1-L5 PDFF values were extracted for each vertebra and averaged for each subject. All subjects underwent DXA of the lumbar spine measuring the average BMD of L1-L4. Results Baseline age, PDFF and BMD showed no significant difference between the two groups (p > 0.05). There was a relative longitudinal increase in mean PDFF (∆relPDFF) in both groups (AI+BP: 5.93%; AI-BP: 3.11%) which was only significant (p = 0.006) in the AI+BP group. ∆relPDFF showed no significant difference between the two groups (p > 0.05). There was no significant longitudinal change in BMD (p > 0.05). Conclusions Over a 12-month period, VBM PDFF assessed with CSE-MRI significantly increased in subjects receiving AI and BP. The present results contradict previous results regarding the effect of only BP therapy on bone marrow fat content quantified by magnetic resonance spectroscopy and bone biopsies. Future longer-term follow-up studies are needed to further characterize the effects of combined AI and BP therapy.

scholarly journals Sex hormones are negatively associated with vertebral bone marrow fat

Bone ◽  
2018 ◽  
Vol 108 ◽  
pp. 20-24 ◽  
Author(s):  
Swaroop D. Mistry ◽  
Gina N. Woods ◽  
Sigurdur Sigurdsson ◽  
Susan K. Ewing ◽  
Trisha F. Hue ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Sex Hormones ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Negatively Associated ◽  
Bone Marrow Fat ◽  
Vertebral Bone Marrow

Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [18F]FDG-PET and MRI study

Bone ◽  
2014 ◽  
Vol 61 ◽  
pp. 33-38 ◽  
Author(s):  
Ville Huovinen ◽  
Virva Saunavaara ◽  
Riku Kiviranta ◽  
Miikka Tarkia ◽  
Henri Honka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Glucose Uptake ◽  
Fdg Pet ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Vertebral Bone Marrow ◽  
18F Fdg ◽  
Mri Study

Assessment of whole spine vertebral bone marrow fat using chemical shift-encoding based water-fat MRI

2015 ◽  
Vol 42 (4) ◽  
pp. 1018-1023 ◽  
Author(s):  
Thomas Baum ◽  
Samuel P. Yap ◽  
Michael Dieckmeyer ◽  
Stefan Ruschke ◽  
Holger Eggers ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chemical Shift ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Vertebral Bone Marrow ◽  
Whole Spine

scholarly journals The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain

2021 ◽  
Author(s):  
Noah B Bonnheim ◽  
Linshanshan Wang ◽  
Anne A Lazar ◽  
Jiamin Zhou ◽  
Ravi Chachad ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Low Back Pain ◽  
Disc Degeneration ◽  
Relaxation Times ◽  
Low Back ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Cartilage Endplate ◽  
Bone Marrow Fat ◽  
Vertebral Bone Marrow

Purpose: The composition of the subchondral bone marrow and cartilage endplate (CEP) could affect intervertebral disc health by influencing vertebral perfusion and nutrient diffusion. However, the relative contributions of these factors to disc degeneration in patients with chronic low back pain (cLBP) have not been quantified. The goal of this study was to use compositional biomarkers derived from quantitative MRI to establish how CEP composition (surrogate for permeability) and vertebral bone marrow fat fraction (BMFF, surrogate for perfusion) relate to disc degeneration. Methods: MRI data from 60 patients with cLBP were included in this prospective observational study (28 female, 32 male; age = 40.0 ± 11.9 years, 19–65 [mean ± SD, min–max]). Ultra-short echo-time MRI was used to calculate CEP T2* relaxation times (reflecting biochemical composition), water-fat MRI was used to calculate vertebral BMFF, and T1ρ MRI was used to calculate T1ρ relaxation times in the nucleus pulposus (NP T1ρ, reflecting proteoglycan content and degenerative grade). Univariate linear regression was used to assess the independent effects of CEP T2* and vertebral BMFF on NP T1ρ. Mixed effects multivariable linear regression accounting for age, sex, and BMI was used to assess the combined relationship between variables. Results: CEP T2* and vertebral BMFF were independently associated with NP T1ρ (p = 0.003 and 0.0001, respectively). After adjusting for age, sex, and BMI, NP T1ρ remained significantly associated with CEP T2* (p = 0.0001) but not vertebral BMFF (p = 0.43). Conclusion: Poor CEP composition may play a significant role in disc degeneration severity and can affect disc health both with and without deficits in vertebral perfusion.

scholarly journals Intervertebral disc degeneration associated with vertebral marrow fat, assessed using quantitative magnetic resonance imaging

2020 ◽  
Vol 49 (11) ◽  
pp. 1753-1763
Author(s):  
Yayun Ji ◽  
Weifeng Hong ◽  
Mouyuan Liu ◽  
Yuying Liang ◽  
YongYan Deng ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Fat Deposition ◽  
Marrow Fat ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Fat Fraction ◽  
Vertebral Bone Marrow

Abstract Objective To investigate the potential clinical application of quantitative MRI in assessing the correlation between lumbar vertebrae bone marrow fat deposition and intervertebral disc degeneration. Materials and methods A total of 104 chronic lower-back pain volunteers underwent 3.0-T MRI with T2-weighted imaging, T2 mapping, and iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL-IQ) between August 2018 and June 2019. Each disc was assessed with T2 value by T2 mapping, and the L1-S1 vertebral bone marrow fat fraction was assessed by IDEAL-IQ. The differences and relationship between T2 value and the adjacent vertebral bone marrow fat fraction values within the five Pfirrmann groups, five age groups, and five lumbar levels were statistically analyzed. Results The vertebral bone marrow fat fraction had a significant negative correlation with T2 values of nucleus pulposus’ T2 values (p < 0.001). However, the significant negative correlation was only found between T2 values of nucleus pulposus and adjacent vertebral bone marrow fat in Pfirrmann II–III, L1/2-L5/S1 level, and 40–49 years’ age groups. Pfirrmann grades of the intervertebral disc were positively correlated with adjacent vertebrae bone marrow fat fraction (p < 0.05). Conclusion Lumbar bone marrow fat deposition significantly increases during the early stages of intervertebral disc degeneration. Quantitative measurements of bone marrow fat deposition and water content of intervertebral discs have a predictive value and are an important supplement to the qualitative traditional classification strategies for the early stages of intervertebral disc degeneration.

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