Endovascular interventions in main renal artery pathologies: an overview and update

2021 ◽  
pp. 028418512110198
Author(s):  
Ansan Joseph ◽  
Jineesh Valakkada ◽  
Anoop Ayappan ◽  
Divyesh Dandhaniya

Renal arteries are involved in a wide spectrum of pathologies including atherosclerosis, fibromuscular dysplasia, Takayasu arteritis, aneurysms, and aortic type B dissections extending into main renal arteries. They manifest as renovascular hypertension, renal ischemia, and cardiovascular dysfunction. The location of the renal arteries in relation to the abdominal aortic aneurysm is a critical determinant of interventional options and long-term prognosis. This article provides a comprehensive review of the role of interventional radiologists in transcatheter interventions in various pathologies involving the main renal arteries with analysis of epidemiology, pathophysiology, newer interventional techniques, and management options.

Author(s):  
David Lloyd ◽  
John Simpson ◽  
Vita Zedere

Fetal hydrops is a form of cardiovascular decompensation unique to fetal physiology, with a wide range of potential causes. In many conditions, it is associated with poor fetal outcome. This chapter explores a challenging case of fetal hydrops, discussing differential diagnoses, methods of echocardiographic assessment, and potential management options. Successful identification and treatment of the underlying cardiac disorder in this case led to complete resolution of hydrops, allowing for full-term delivery, with a good long-term prognosis.


2019 ◽  
Vol 69 (6) ◽  
pp. e82-e83
Author(s):  
Laura Paperetti ◽  
Sara Speziali ◽  
Fabrizio Masciello ◽  
Aaron Fargion ◽  
Rossella Di Domenico ◽  
...  

2020 ◽  
Vol 272 (5) ◽  
pp. 773-778
Author(s):  
Ruth M. A. Bulder ◽  
Mareia Talvitie ◽  
Esther Bastiaannet ◽  
Jaap F. Hamming ◽  
Rebecka Hultgren ◽  
...  

2020 ◽  
Vol 81 (5) ◽  
pp. 1-6
Author(s):  
Jasmine Brown ◽  
Sandesh Lakkol ◽  
Sophia Lazenby ◽  
Mark Harris

Neoplasm of the spinal column in children is rare, but can involve either benign or malignant tumours. Early detection of malignant tumours is key to successful clinical outcome and long-term prognosis. In such cases, back pain is a common presenting symptom, but often has a non-neoplastic cause. Therefore, it is important for GPs and trainees who encounter paediatric patients to be aware of the clinical entity to be able to thoroughly assess them in clinical practice. This article discusses the types of paediatric spinal neoplasms, anatomical-based classification, clinical red flags, imaging modalities and outlines brief management options.


Gut ◽  
2021 ◽  
pp. gutjnl-2020-322564 ◽  
Author(s):  
Ramy Younes ◽  
Olivier Govaere ◽  
Salvatore Petta ◽  
Luca Miele ◽  
Dina Tiniakos ◽  
...  

ObjectiveThe full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis of Caucasian lean subjects with NAFLD.DesignThe study cohort comprises 1339 biopsy-proven NAFLD subjects from four countries (Italy, UK, Spain and Australia), stratified into lean and non-lean (body mass index (BMI) </≥25 kg/m2). Liver/non-liver-related events and survival free of transplantation were recorded during the follow-up, compared by log-rank testing and reported by adjusted HR.ResultsLean patients represented 14.4% of the cohort and were predominantly of Italian origin (89%). They had less severe histological disease (lean vs non-lean: non-alcoholic steatohepatitis 54.1% vs 71.2% p<0.001; advanced fibrosis 10.1% vs 25.2% p<0.001), lower prevalence of diabetes (9.2% vs 31.4%, p<0.001), but no significant differences in the prevalence of the PNPLA3 I148M variant (p=0.57). During a median follow-up of 94 months (>10 483 person-years), 4.7% of lean vs 7.7% of non-lean patients reported liver-related events (p=0.37). No difference in survival was observed compared with non-lean NAFLD (p=0.069).ConclusionsCaucasian lean subjects with NAFLD may progress to advanced liver disease, develop metabolic comorbidities and experience cardiovascular disease (CVD) as well as liver-related mortality, independent of longitudinal progression to obesity and PNPLA3 genotype. These patients represent one end of a wide spectrum of phenotypic expression of NAFLD where the disease manifests at lower overall BMI thresholds.Lay summaryNAFLD may affect and progress in both obese and lean individuals. Lean subjects are predominantly males, have a younger age at diagnosis and are more prevalent in some geographic areas. During the follow-up, lean subjects can develop hepatic and extrahepatic disease, including metabolic comorbidities, in the absence of weight gain. These patients represent one end of a wide spectrum of phenotypic expression of NAFLD.


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