scholarly journals Treatment and follow-up of fetuses that developed congenital heart block due to autoantibody in two cases

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092559
Author(s):  
Min Hou ◽  
Ying Zhao ◽  
Xiao-Wei Liu ◽  
Yi-Hua He
Keyword(s):  
Autoimmune Disease ◽  
Heart Block ◽  
Congenital Heart ◽  
Clinical Manifestations ◽  
In Utero ◽  
Congenital Heart Block ◽  
The Other ◽  
Early Screening ◽  
Prenatal Intervention

Objective Autoantibody-related congenital heart block (ACHB) is a passively acquired autoimmune disease. This study aimed to examine the pathogenesis, clinical manifestations, and treatment of ACHB. Method The clinical data of two fetuses with first-degree ACHB were retrospectively analyzed. Results Two pregnant women were strongly positive for anti-Sjögren’s syndrome-related antigen A (SSA) antibody. Among these two cases, one had a prolonged atrioventricular (AV) interval at 28+3 weeks in utero, while the other had a prolonged AV interval at 24+6 weeks in utero. After prenatal intervention, one patient recovered to normal, while one fetus continued to have ACHB after treatment with dexamethasone and intravenous immunoglobulin. Furthermore, the two neonates were positive for anti-SSA antibody and were diagnosed with ACHB. Conclusion The pathogenesis of ACHB is closely correlated with anti-SSA/Ro antibody and anti-SSB/La antibody from the mother, and is affected by fetal susceptibility. Early screening and early intervention for ACHB are important.

scholarly journals Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero

2019 ◽  
Vol 79 (8) ◽  
pp. e94-e94 ◽  
Author(s):  
Hasan Satış ◽  
Reyhan Bilici Salman ◽  
Aslihan Avanoğlu Güler ◽  
Hazan Karadeniz ◽  
Şeyma Yıldız ◽  
...  
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block ◽  
Term Outcome ◽  
Long Term Outcome

In Utero identification and therapy of congenital heart block

Lupus ◽  
1995 ◽  
Vol 4 (2) ◽  
pp. 116-121 ◽  
Author(s):  
JP Buyon ◽  
J. Waltuck ◽  
C. Kleinman ◽  
J. Copel
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block

scholarly journals Long term follow-up of congenital heart block

1991 ◽  
Vol 17 (2) ◽  
pp. A325
Author(s):  
Cynthia M. Pordon ◽  
Douglas S. Moodie ◽  
Richard Sterba ◽  
Andrea Homa
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
Congenital Heart Block ◽  
Long Term Follow Up

scholarly journals Outcome of isolated congenital heart block diagnosed in utero.

Heart ◽  
1997 ◽  
Vol 78 (1) ◽  
pp. 95-96 ◽  
Author(s):  
L. G. Guereta ◽  
M. Burgueros ◽  
F. Moreno
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block

scholarly journals Congenital Heart Block Not Associated with Anti-Ro/La Antibodies: Comparison with Anti-Ro/La-positive Cases

2009 ◽  
Vol 36 (8) ◽  
pp. 1744-1748 ◽  
Author(s):  
ANTONIO BRUCATO ◽  
CHIARA GRAVA ◽  
MARIA BORTOLATI ◽  
KEIGO IKEDA ◽  
ORNELLA MILANESI ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Atrioventricular Block ◽  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block ◽  
Complete Atrioventricular Block ◽  
Laboratory Methods ◽  
Complete Atrioventricular

Objective.To study anti-Ro/La-negative congenital heart block (CHB).Methods.Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods.Results.There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers.Conclusion.Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.

scholarly journals New lead for in utero pacing for fetal congenital heart block

2003 ◽  
Vol 126 (1) ◽  
pp. 300-302 ◽  
Author(s):  
Renato S. Assad ◽  
Paulo Zielinsky ◽  
Renato Kalil ◽  
Gustavo Lima ◽  
Anna Aramayo ◽  
...  
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block

scholarly journals Prevention and Treatment In Utero of Autoimmune-Associated Congenital Heart Block

2014 ◽  
Vol 22 (6) ◽  
pp. 263-267 ◽  
Author(s):  
Amit Saxena ◽  
Peter M Izmirly ◽  
Barbara Mendez ◽  
Jill P. Buyon ◽  
Deborah M. Friedman
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block ◽  
Prevention And Treatment

In utero Pacing for Fetal Congenital Heart Block

1994 ◽  
Vol 9 (3) ◽  
pp. 183-185 ◽  
Author(s):  
S.A. Walkinshaw ◽  
C.R. Welch ◽  
J. McCormack ◽  
K. Walsh
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block

scholarly journals Cutaneous neonatal lupus with cutis marmorata telangiectatica congenita-like lesions

2013 ◽  
Vol 88 (3) ◽  
pp. 428-431 ◽  
Author(s):  
Flavia Trevisan ◽  
Paulo Rowilson Cunha ◽  
Clovis Antonio Lopes Pinto ◽  
Fernanda Gomes Cattete
Keyword(s):  
Rare Disease ◽  
Heart Block ◽  
Congenital Heart ◽  
Clinical Manifestations ◽  
Congenital Heart Block ◽  
Neonatal Lupus ◽  
Cutaneous Manifestations ◽  
Cutis Marmorata Telangiectatica Congenita ◽  
The Face ◽  
Cutaneous Lupus

Neonatal lupus is a rare disease caused by the transplacental transfer of maternal autoantibodies to the foetus, characterized by transient clinical manifestations such as cutaneous, haematological, and hepatobiliary events or permanent such as congenital heart block. The typical cutaneous manifestations include erythematous, scaly, annular or arched lesions on the face, with slight central atrophy and photosensitivy, clinically and histologically similar to subacute cutaneous lupus. However, in some cases, the lesions may resemble those in cutis marmorata telangiectatica congenita, although this phenomenon is rare and only eight such cases have been reported to date. We report a case of cutaneous neonatal lupus with atypical lesions on the limbs, which had a reddish-purple marbled appearance, resembling the lesions in cutis marmorata telangiectatica congenita.

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