scholarly journals Congenital Heart Block Not Associated with Anti-Ro/La Antibodies: Comparison with Anti-Ro/La-positive Cases

2009 ◽  
Vol 36 (8) ◽  
pp. 1744-1748 ◽  
Author(s):  
ANTONIO BRUCATO ◽  
CHIARA GRAVA ◽  
MARIA BORTOLATI ◽  
KEIGO IKEDA ◽  
ORNELLA MILANESI ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Atrioventricular Block ◽  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block ◽  
Complete Atrioventricular Block ◽  
Laboratory Methods ◽  
Complete Atrioventricular

Objective.To study anti-Ro/La-negative congenital heart block (CHB).Methods.Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods.Results.There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers.Conclusion.Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.

scholarly journals Complete Heart Block, Severe Right Ventricular Dysfunction in a Child with COVID-19 Infection

2021 ◽  
pp. 1-10
Author(s):  
Sezen Gulumser Sisko ◽  
Sezen Ugan Atik ◽  
Cem Karadeniz ◽  
Alper Guzeltas ◽  
Yakup Ergul
Keyword(s):  
Atrioventricular Block ◽  
Heart Block ◽  
Ventricular Dysfunction ◽  
Complete Heart Block ◽  
Pacemaker Implantation ◽  
Right Ventricular Dysfunction ◽  
Right Heart Failure ◽  
Complete Atrioventricular Block ◽  
Right Heart ◽  
Complete Atrioventricular

Abstract A young child presented with hepatomegaly, ascites, and bradycardia in the setting of coronavirus disease-2019. Permanent complete atrioventricular block and severe right heart failure were diagnosed. He was treated with surgical epicardial pacemaker implantation. This report is the first description of coronavirus disease-2019–induced permanent complete atrioventricular block in a child.

scholarly journals Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero

2019 ◽  
Vol 79 (8) ◽  
pp. e94-e94 ◽  
Author(s):  
Hasan Satış ◽  
Reyhan Bilici Salman ◽  
Aslihan Avanoğlu Güler ◽  
Hazan Karadeniz ◽  
Şeyma Yıldız ◽  
...  
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block ◽  
Term Outcome ◽  
Long Term Outcome

In Utero identification and therapy of congenital heart block

Lupus ◽  
1995 ◽  
Vol 4 (2) ◽  
pp. 116-121 ◽  
Author(s):  
JP Buyon ◽  
J. Waltuck ◽  
C. Kleinman ◽  
J. Copel
Keyword(s):  
Heart Block ◽  
Congenital Heart ◽  
In Utero ◽  
Congenital Heart Block

Successful management of fetal hydrops due to congenitally complete atrioventricular block

2003 ◽  
Vol 13 (4) ◽  
pp. 380-383 ◽  
Author(s):  
Jacintha Sivarajah ◽  
Ian C. Huggon ◽  
Eric Rosenthal
Keyword(s):  
Preterm Delivery ◽  
Atrioventricular Block ◽  
Heart Block ◽  
Complete Heart Block ◽  
Complete Atrioventricular Block ◽  
Successful Management ◽  
Fetal Hydrops ◽  
Complete Atrioventricular

At 32 weeks, a fetus was found to be hydropic with congenitally complete heart block in an asymptomatic mother who was positive to anti-Ro antibodies. Maternal therapy with oral salbutamol was successful in prolonging gestation for a period of 3 weeks so that preterm delivery was delayed until the 35th week of gestation. Following treatment with inotropes and diuretics, a permanent transvenous pacemaker was implanted at 8 weeks of age. The child is now thriving at 20 months of age.

scholarly journals Successful Prevention of Fetal Autoimmune-Mediated Heart Block by Combined Therapies With Hydroxychloroquine and Intravenous Immunoglobulin: A Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Li Zhao ◽  
Yan Zhou ◽  
Chuan Wang ◽  
Yifei Li ◽  
Qi Zhu ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Atrioventricular Block ◽  
Heart Block ◽  
Immunoglobulin A ◽  
Atrioventricular Node ◽  
Complete Atrioventricular Block ◽  
Life Threatening ◽  
Short Time ◽  
Successful Prevention ◽  
Complete Atrioventricular

A fetal autoimmune-mediated atrioventricular block is a passively acquired autoimmune disease in which maternal autoantibodies enter the fetal circulation via the placenta and subsequently cause inflammation and fibrosis of the atrioventricular node. Once fetal autoimmune-mediated atrioventricular block occurs, it only takes a short time to progress from first-degree atrioventricular block to complete atrioventricular block, meaning that the damage is often irreversible. Autoimmune—associated AVB, a rare but life—threatening disorder, occurs in 2–5% of pregnancies with positive anti—Ro/SSA (the most common one) and La/SSB antibodies. The perinatal mortality of neonates with AVB outlined in research is approximately 30%. Thus far, for autoimmune-associated AVB fetuses, currently used treatments include corticosteroids, hydroxychloroquine, intravenous immunoglobulin (IVIG), b—sympathomimetic agent, and even plasma exchange. Currently, approaches for preventing the progression and recurrence of a fetal atrioventricular block are still controversial. Here, we reported a baby of successful prevention from the fate of the fetal atrioventricular block by adopting prophylactic comprehensive prenatal therapy.

scholarly journals Fetal cardiology in the Czech Republic: current management of prenatally diagnosed congenital heart diseases and arrhythmias

2009 ◽  
pp. S159-S166
Author(s):  
V Tomek ◽  
J Marek ◽  
H Jičínská ◽  
J Škovránek
Keyword(s):  
Heart Failure ◽  
Czech Republic ◽  
Supraventricular Tachycardia ◽  
Atrioventricular Block ◽  
Congenital Heart ◽  
Fetal Mortality ◽  
Ultrasound Screening ◽  
Complete Atrioventricular Block ◽  
The Czech Republic ◽  
Complete Atrioventricular

Reliable diagnosis of congenital heart defects and arrhythmias in utero has been possible since the introduction of fetal echocardiography. The nation-wide prenatal ultrasound screening program in the Czech Republic enabled detection of cardiac abnormities in 1/3 of patients born with any congenital heart disease and up to 83 % of those with critical forms. Prenatal frequency of individual heart anomalies significantly differed from the postnatal frequency. Fetal isolated complete atrioventricular block and supraventricular tachycardia may lead to heart failure and are important causes of fetal mortality. The regression of heart failure was achieved by a conversion to the sinus rhythm in the supraventricular tachycardia and by increase of ventricular rate in the complete atrioventricular block.

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