Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury

Objective This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p. Methods We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed. Results Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival. Conclusion Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF.

Download Full-text

MicroRNA‐423‐5p as a biomarker for early diagnosis and outcome prediction of acute kidney injury in patients with acute decompensated heart failure

International Journal of Urology ◽

10.1111/iju.14380 ◽

2020 ◽

Author(s):

Hongmei Zhang ◽

Jiaolei Liu ◽

Xin Li ◽

Lin Wang ◽

Huining Yu ◽

...

Keyword(s):

Heart Failure ◽

Acute Kidney Injury ◽

Early Diagnosis ◽

Outcome Prediction ◽

Acute Decompensated Heart Failure ◽

Kidney Injury ◽

Decompensated Heart Failure

Download Full-text

Neutrophil gelatinase-associated lipocalin for early diagnosis of acute kidney injury in patients with acute decompensated heart failure

Kardiologiia ◽

10.18087/cardio.2500 ◽

2018 ◽

Vol 17 (S10) ◽

pp. 44-50

Author(s):

M. V. Ledyakhova ◽

◽

S. N. Nasonova ◽

I. V. Zhirov ◽

E. B. Yarovaya ◽

...

Keyword(s):

Heart Failure ◽

Acute Kidney Injury ◽

Early Diagnosis ◽

Acute Decompensated Heart Failure ◽

Kidney Injury ◽

Decompensated Heart Failure ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Neutrophil Gelatinase

Download Full-text

P787Long-term prognostic value of the combination of fibrosis-4 index and acute kidney injury in patients with admitted for acute decompensated heart failure

European Heart Journal ◽

10.1093/eurheartj/ehz747.0386 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

T Yamada ◽

T Morita ◽

Y Furukawa ◽

S Tamaki ◽

M Kawasaki ◽

...

Keyword(s):

Heart Failure ◽

Acute Kidney Injury ◽

Acute Decompensated Heart Failure ◽

Prognostic Significance ◽

Liver Stiffness ◽

Total Mortality ◽

Kidney Injury ◽

Decompensated Heart Failure ◽

Left Ventricular ◽

Nitrogen Levels

Abstract Background Liver dysfunction in patients with heart failure (HF) is caused by liver congestion, which is related to liver stiffness. It was reported that liver stiffness assessed by non-invasive fibrosis marker such as Fibrosis-4 (FIB4) index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) predicts mortality in HF pts. Acute kidney injury (AKI) during HF treatment is associated with poor outcome in pts admitted for acute decompensated heart failure (ADHF). However, there is no information available on the long-term prognostic significance of the combination of FIB4 index and AKI in ADHF pts. Methods and results We studied 299 ADHF pts with survival discharge. FIB4 index was calculated by the formula: age (yrs) × AST[U/L]/(platelets [103/μL] × (ALT[U/L])1/2). AKI during ADHF treatment was defined according to AKI Network criteria (stage 1: mild, stage 2: moderate, stage 3: severe). During a follow-up period of 4.3±3.3 yrs, 94 pts died. At multivariate Cox analysis, FIB4 index and stage2/3 AKI, but not stage1 AKI, significantly associated with total mortality, independently of prior HF hospitalization and serum sodium and blood urea nitrogen levels after adjustment with BMI, systolic blood pressure, hemoglobin, serum creatinine and albumin levels, left ventricular end-diastolic and left atrial dimension indexes. Pts with both greater FIB4 index (>2.674: median) and stage 2/3 AKI had a significantly higher risk of total mortality than those with none of them. Adjusted hazard ratio in pts with both greater FIB4 index and stage 2/3 AKI was 3.5 (95% CI 1.6–7.7), which was two-fold of that in pts with either of them (1.7 [95% CI 1.1–2.7]). Conclusion The combination of FIB4 index and moderate to severe AKI might identify higher risk subset for total mortality in ADHF pts.

Download Full-text