The Critical Oestrogen Content of Combined Oral Contraceptives

1975 ◽  
Vol 3 (6) ◽  
pp. 407-412 ◽  
Author(s):  
J P Mumford
Keyword(s):  
Side Effects ◽  
Oral Contraceptives ◽  
Patient Acceptance ◽  
Similar Reduction ◽  
Combined Oral Contraceptives ◽  
Critical Dose ◽  
Irregular Bleeding

A review of the evidence concerning efficacy, safety and side-effects of oral contraceptives indicates clear differences related to the lowering of oestrogen dosage. It is suggested that 50 μ g of ethinyloestradiol or its equivalent is a critical dose, for below that level the efficacy in combination with current progestogens falls almost twenty-fold without evidence of a similar reduction in unwanted side-effects. In fact there is a marked increase of irregular bleeding patterns in early cycles associated with diminished patient acceptance.

Combined oral contraceptives in improving quality of young women’s lives

2019 ◽  
Vol 1 (1) ◽  
pp. 15-18
Author(s):  
A. L. Tikhomirov ◽  
T. A. Yudina ◽  
D. I. Burchakov
Keyword(s):  
Side Effects ◽  
Oral Contraceptives ◽  
Hormonal Contraception ◽  
Hormonal Contraceptive ◽  
Combined Oral Contraceptives ◽  
Distinctive Features ◽  
Women's Lives ◽  
Combined Hormonal Contraceptive

Compliance with the use of combined hormonal contraceptive drugs containing drospirenone is presented. The use of such drugs enhances the use of hormonal contraception. The distinctive features of the drugs are considered: reliable contraception, reduced severity of side effects, additional positive preventive and curative effects.

scholarly journals How to reduce the number of side effects produced by COCs and improve adherence: simple tips for practitioners

2016 ◽  
pp. 10-13
Author(s):  
G. B. Dikke
Keyword(s):  
Side Effects ◽  
Oral Contraceptives ◽  
Low Dose ◽  
Oral Contraception ◽  
Combined Oral Contraceptives ◽  
Mineral Supplements ◽  
Common Causes ◽  
Natural Hormones

The frequency and severity of side effects induced by the use of combined oral contraceptives (COCs) are the most common causes of withdrawal (64.4%). Better adherence can be achieved through adequate counselling on the choice of contraception and use of extended-regimen low-dose COCs with estrogen component and natural hormones containing novel selective progestins (dienogest, drospirenone) with minimum side effects. The choice of vitamin and mineral supplements based on the relevant micronutrient disbalance in women using COCs and "quick starting" could also contribute to compliance with the chosen method of oral contraception.

scholarly journals Combined oral contraceptives with shortened hormone-free interval. Proven advantages of the therapy regime

2019 ◽  
pp. 56-62
Author(s):  
G. B. Dikke
Keyword(s):  
Side Effects ◽  
Pelvic Pain ◽  
Oral Contraceptives ◽  
Combined Oral Contraceptives ◽  
Free Interval ◽  
Estradiol Levels

Objective: To determine the benefits of COC in the 26/2 mode compared with the traditional 21/7 in reducing the frequency of side effects. Main provisions. Side effects – the main cause of women’s refusals to take COCs – occur predominantly on days of taking pills without hormones due to a drop in estradiol levels. Reduction of the hormone-free COC interval (mode 26/2) reduces the frequency of headache and pelvic pain and other symptoms. Conclusion. COC, with regimen 26/2, may be a promising option for users who experience adverse symptoms.

scholarly journals Observational Study for Adverse Effects and Discontinuation with Long-Term Post-Operative Hormonal Treatment for Endometriosis in Real-World Practice

2021 ◽  
Vol 36 (2) ◽  
pp. 116-124
Author(s):  
In Hye Kim ◽  
Hyungjoon Yoon ◽  
Hyun Joo Lee ◽  
Hye Kyung Noh ◽  
Jong Kil Joo ◽  
...  
Keyword(s):  
Side Effects ◽  
Oral Contraceptives ◽  
Medical Records ◽  
Ethinyl Estradiol ◽  
Hormonal Treatment ◽  
Recurrence Rates ◽  
Continuous Administration ◽  
Combined Oral Contraceptives ◽  
The Mean

Objectives: To evaluate the side effects and causes of discontinuation of either combined oral contraceptives or dienogest (DNG) used to prevent recurrence in patients with surgically confirmed endometriosis.Methods: We retrospectively analyzed the medical records of 213 women with endometriosis who had been treated with combined oral contraceptives (ethinyl estradiol 0.02 mg/drospirenone 3 mg [EE/DRSP]) or DNG 2 mg for 12 months or more. The side effects reported by the patients, laboratory parameters, causes of discontinuation of medication, and recurrence rates were evaluated one, two, three, four, and five years after starting medication (Y1, Y2, Y3, Y4, and Y5).Results: EE/DRSP were administered to 59 patients, while DNG was administered to 154 patients. The mean durations of postoperative use of EE/DRSP and DNG were 44.5 ± 22.6 months and 23.6 ± 13.5 months, respectively. The prevalence of side effects was 27.1%, 19.0%, 10.0%, 10.5%, and 7.4% in the EE/DRSP group and 29.2%, 15.7%, 14.0%, 23.1%, and 0.0% in the DNG group at Y1, Y2, Y3, Y4, and Y5, respectively. The discontinuation rates were 1.7%, 1.7%, 4.0%, 0.0%, and 7.4% at Y1, Y2, Y3, Y4, and Y5, respectively, in the EE/DRSP group and 10.4%, 3.3%, 4.0%, 3.8%, and 0.0% at the same times in the DNG group. The recurrence rates were less than 4% in both the groups.Conclusions: The side effects of commonly prescribed postoperative hormone treatments were relatively mild, and the occurrence of side effects decreased with continuous administration. Further, the long-term use of postoperative hormone treatments is likely to prevent recurrence of endometriosis after surgery.

Efficacy and acceptability of the vaginal combination hormone system containing ethinylestradiol and etonogestrel. Literature rewiev

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 6-11
Author(s):  
Elena A Mezhevitinova ◽  
Vera N Prilepskaya
Keyword(s):  
Side Effects ◽  
Oral Contraceptives ◽  
High Efficiency ◽  
Vaginal Ring ◽  
Combined Oral Contraceptives ◽  
Daily Monitoring ◽  
Comparative Aspect ◽  
Hormone System

The review focuses on evaluating the effectiveness and acceptability of a vaginal ring and combined oral contraceptives (COC) in a comparative aspect. It is shown that the vaginal ring has high efficiency, comparable to COC, has better cycle control, fewer side effects, is convenient to use, there is no need for daily monitoring of the pill.

Platelet Adhesiveness in Symptomatic Women Taking Oral Contraceptives

1971 ◽  
Vol 26 (03) ◽  
pp. 426-430 ◽  
Author(s):  
T. F Zuck ◽  
J. J Bergin ◽  
Jane M. Raymond ◽  
W. R Dwyre ◽  
D. G Corby
Keyword(s):  
Oral Contraceptives ◽  
Platelet Adhesiveness ◽  
Combined Oral Contraceptives ◽  
Increased Risk ◽  
Normal Women ◽  
Asymptomatic Women

SummaryPlatelet adhesiveness to glass was determined in several groups of women. Increases were found in women developing thrombovascular symptoms while taking combined oral contraceptives, compared to both normal women and asymptomatic users of oral contraceptives. Despite this increase, overlap of the groups did not permit discrimination between symptomatic and asymptomatic women. However, it is possible, that in concert with other coagulation changes, platelet adhesiveness to glass may prove adjunctive in defining women at increased risk of developing thrombovascular symptoms while taking oral contraceptives, and further define the mechanism of the increased risk.

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