High Prevalence of Occult Papillary Thyroid Carcinoma in a Surgical Series for Benign Thyroid Disease

The long non-coding RNA (lncRNA) GAS8-AS1 is the second-most frequently altered gene, following the BRAF gene, in papillary thyroid carcinoma (PTC). We aimed to study the specificity and significance of genetic alterations in GAS8-AS1 in PTC. In this study, we reported the prevalence of genetic alterations of GAS8-AS1 in tissues of 48 nodular goiter, 573 papillary thyroid cancer, 95 colorectal cancer, 101 non-small cell lung cancer, 92 glioma, and 69 gastrointestinal stromal tumor patients, and in peripheral white blood cells of 286 healthy volunteers. We observed that the genomic sequence of GAS8-AS1 had a high frequency of genetic alterations in addition to the previously reported c.713A>G/714T>C substitution. Substitution of c.713A>G was completely linked with four other loci at c.714T>C, c.728A>G, c.737G>A, and c.752G>A. Two novel substitutions at c.749G>A and c.826A>G were also found. Interestingly, evidence from different samples indicated that these variations were not unique variants for PTC; they were also found in other malignant tissues and white blood cells of healthy volunteers. The c.713A>G substitution was associated with the T stage of PTC, while c.749G>A was more likely to occur in younger patients with PTC. PTC patients carrying heterozygous variants at the c.749 and c.826 loci had a higher risk of developing multiple lesions. These associations were also observed in patients with PTC and concomitant benign thyroid disease. Notably, the rare homozygous GG at the c.826 site conferred a higher risk of developing T2 PTC without benign thyroid disease, and a lower risk of developing T2 PTC with benign thyroid disease. Alterations of c.749G>A and c.826A>G had higher levels of serum TSH (thyroid stimulating hormone) in PTC subjects. Our study provides evidence that the detection of GAS8-AS1 genetic alterations would be useful in diagnostic screening and prognostic assessment of PTC.

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Coexistence of papillary thyroid carcinoma and autoimmune thyroid disease

Endocrine Abstracts ◽

10.1530/endoabs.56.p1158 ◽

2018 ◽

Author(s):

Imen Sakka ◽

Ibtissem Oueslati ◽

Melika Chihaoui ◽

Fatma Chaker ◽

Meriem Yazidi ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Papillary Thyroid ◽

Autoimmune Thyroid

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Distinct Metabolomic Profiles of Papillary Thyroid Carcinoma and Benign Thyroid Adenoma

Journal of Proteome Research ◽

10.1021/acs.jproteome.5b00351 ◽

2015 ◽

Vol 14 (8) ◽

pp. 3315-3321 ◽

Cited By ~ 18

Author(s):

Yanan Xu ◽

Xiaojiao Zheng ◽

Yunping Qiu ◽

Wei Jia ◽

Jiadong Wang ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Adenoma ◽

Papillary Thyroid ◽

Benign Thyroid

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BRAFK601E Mutation in a Follicular Thyroid Adenoma: A Case Report

International Journal of Surgical Pathology ◽

10.1177/1066896916688083 ◽

2017 ◽

Vol 25 (4) ◽

pp. 348-351 ◽

Cited By ~ 9

Author(s):

Elisabetta Macerola ◽

Liborio Torregrossa ◽

Clara Ugolini ◽

Sohail Bakkar ◽

Paolo Vitti ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Treatment Plan ◽

Follicular Adenoma ◽

Surrounding Tissue ◽

Papillary Thyroid ◽

Follicular Variant ◽

Thyroid Lesion ◽

Cytological Smear ◽

Benign Thyroid

BRAF mutations represent the most common genetic alteration in papillary thyroid carcinoma (PTC). The p.V600E mutation is specific for the classic and tall-cell variants of PTC and has been associated with a more aggressive biologic behavior. On the other hand, the p.K601E mutation is peculiar to the follicular variant of PTC, and seems to be a favorable prognostic indicator. A 12-year-old boy presented with a 10-mm left-sided thyroid nodule. Fine-needle aspiration cytology reported the lesion as suspicious for a follicular neoplasm (Bethesda category IV). The patient underwent lobectomy, and histopathology revealed a follicular adenoma with normal surrounding tissue. The cytological smear was found to be positive for BRAF p.K601E mutation, and this was later confirmed on the corresponding paraffin block. This case was independently revised by 4 expert pathologists, all of whom confirmed the benign nature of the thyroid lesion. This article describes the presence of a BRAF mutation in a benign thyroid lesion. To the authors’ knowledge, this is the fourth case of follicular adenoma carrying BRAFK601E reported in literature to date. BRAFK601E mutation can occur in benign thyroid lesions. This finding, in the context of the current literature and the recently proposed reclassification of the noninvasive encapsulated follicular variant of papillary thyroid carcinoma into a benign lesion, confirms the importance of preoperative BRAF p.K601E testing in offering patients a tailored treatment plan and avoiding overtreatment.

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High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma

Carcinogenesis ◽

10.1093/carcin/bgu051 ◽

2014 ◽

Vol 35 (7) ◽

pp. 1564-1572 ◽

Cited By ~ 21

Author(s):

Maqbool Ahmed ◽

Azhar R. Hussain ◽

Prashant Bavi ◽

Saeeda O. Ahmed ◽

Saif S. AlSobhi ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Papillary Thyroid ◽

Complex Activity ◽

High Prevalence

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T2* mapping at 3.0T MRI for differentiation of papillary thyroid carcinoma from benign thyroid nodules

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.25041 ◽

2015 ◽

Vol 43 (4) ◽

pp. 956-961 ◽

Cited By ~ 4

Author(s):

Ruoyang Shi ◽

Qiuying Yao ◽

Lianming Wu ◽

Qinyi Zhou ◽

Qing Lu ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Nodules ◽

T2 Mapping ◽

Papillary Thyroid ◽

3.0T Mri ◽

Benign Thyroid Nodules ◽

Benign Thyroid

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INCIDENTAL THYROID CARCINOMA IN A LARGE SERIES OF CONSECUTIVE PATIENTS OPERATED ON FOR BENIGN THYROID DISEASE

ANZ Journal of Surgery ◽

10.1111/j.1445-2197.2006.03667.x ◽

2006 ◽

Vol 76 (3) ◽

pp. 123-126 ◽

Cited By ~ 60

Author(s):

Paolo Miccoli ◽

Michele N. Minuto ◽

David Galleri ◽

Jacopo D'Agostino ◽

Fulvio Basolo ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Thyroid Disease ◽

Large Series ◽

Benign Thyroid Disease ◽

Incidental Thyroid Carcinoma ◽

Benign Thyroid

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Immunohistochemical Study of Papillary Thyroid Carcinoma and Possible Papillary Thyroid Carcinoma-related Benign Thyroid Nodules

Pathology - Research and Practice ◽

10.1016/s0344-0338(00)80025-4 ◽

2000 ◽

Vol 196 (8) ◽

pp. 533-540 ◽

Cited By ~ 17

Author(s):

Kien T. Mai ◽

Jason C. Ford ◽

Hossein M. Yazdi ◽

D. Garth Perkins ◽

A. Susan Commons

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Nodules ◽

Immunohistochemical Study ◽

Papillary Thyroid ◽

Benign Thyroid Nodules ◽

Benign Thyroid

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The Clinical and Prognosis Value of the Number of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma Patients

10.21203/rs.3.rs-96102/v1 ◽

2020 ◽

Author(s):

Ling Zhan ◽

Hong-fang Feng ◽

Xi-zi Yu ◽

Ling-rui Li ◽

Jun-long Song ◽

...

Keyword(s):

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Lymph Nodes ◽

Tumor Size ◽

Tumor Diameter ◽

Papillary Thyroid ◽

Metastatic Lymph Nodes ◽

Metastatic Lymph ◽

High Prevalence

Abstract Objective: It has been reported that papillary thyroid carcinoma (PTC) patients with lymph node metastasis (LNM) are more associated with adverse outcomes. This study aimed to assess the correlation between the lymph node (LN) status and clinical prognosis in PTC patients. Methods: We retrospectively reviewed the medical records of PTC patients who underwent initial thyroid cancer surgery in Renmin Hospital of Wuhan University between 2017 and 2019. 1021 PTC patients with total checked number of lymph nodes ≥5 were involved in this study. The clinicopathological characteristics of patients were compared according to the LN status and the number of metastatic lymph nodes (NMLNs). Results: The LNM and NMLNs>5 were seen in 694 (68.0%) and 222 (21.7%) cases, respectively. Young patients, patients with larger tumor diameter, bilaterality, multifocality and gross extrathyroidal extension (ETE) were more inclined to LNM and NMLNs >5 (P<0.001). The patients with LNM (pN1) were mainly among males and were exhibited multifocality and advanced tumor stage (P<0.001), while pN1 patients with NMLNs >5 were negatively associated with advanced tumour stage (P<0.05). Recurrence-free survival among pN1 patients was significantly different between 2 groups (NMLNs ≤5: 0/472, 100.0%; NMLNs >5: 5/222, 97.7%; P=0.002). In multivariate logistic regression analysis, the male (OR=2.580, P<0.001), 10-mm tumor size (OR=1.770, P<0.001), tumor gross ETE (OR=2.004, P<0.001) were independent predictors for the high prevalence of LNM. Similarly, 10-mm tumor size (OR=1.399, P<0.05), bilaterality (OR=2.350, P<0.001) and tumor gross ETE (OR=2.660, P<0.05) were also independent predictors for the high prevalence of NMLNs >5; 10-year age was an independent predictor for the low prevalence of the LNM (OR=0.658, P<0.001) and NMLNs >5 (OR=0.678, P<0.001). Conclusions: The status of the cervical LNs and the NMLNs should be correctly evaluated to guide reasonable treatment and careful follow-up.

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