Doppler Flowmetry and the Diagnosis of Breast Lumps

1991 ◽  
Vol 77 (6) ◽  
pp. 468-471 ◽  
Author(s):  
Enrico Gallo ◽  
Emanuele Galante ◽  
Gabriele Martelli ◽  
Marco Stanzani ◽  
Grazia Landi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Flow Analysis ◽  
Mean Value ◽  
Doppler Signal ◽  
Breast Cancers ◽  
Benign Lesions ◽  
Histologic Diagnosis ◽  
Doppler Flowmetry ◽  
Blood Flow Analysis ◽  
Breast Lumps

The aim of the study was to ascertain the reliability of a Doppler signal in the diagnosis of breast cancer. Computerized blood flow analysis was performed on 117 patients who presented with a breast lump at the Division of Diagnostic Oncology of the Istituto Nazionale Tumori of Milan. The values of systolic peak and diastolic frequency were evaluated in relation to the histologic diagnosis. Ten patients had a spontaneous regression of the lump and were excluded from the study. The number of evaluable cases with histologic confirmation was 107: 69 carcinomas and 38 benign lesions. Systolic peak values for the 69 carcinomas ranged from 1500 to 7400 Hz, with a mean value of 3243.4 Hz; diastolic frequency ranged from 200 to 3700 Hz, with mean value of 1413.9 Hz. No diagnostic signals were found in 4 breast cancers (false negatives). Twenty-three of 38 benign lesions (60.5 %) and 65 of 69 malignant nodes (94.2 %) were correctly diagnosed. The Doppler signal with computerized spectral analysis in addition to more specific ultrasonographic parameters could be considered a useful tool in the diagnosis of breast cancer.

scholarly journals Clinicopathologic study of breast lumps in Abakaliki, South Eastern Nigeria

2016 ◽  
Vol 7 (3) ◽  
pp. 58-64 ◽  
Author(s):  
Ogbuanya Aloysius Ugwu-Olisa ◽  
Anyanwu Stanley Nnamdi ◽  
Nwigwe Chinedu Gregory ◽  
Iyare Festus
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Age Groups ◽  
Breast Cancers ◽  
Related Factors ◽  
Histologic Diagnosis ◽  
Female Ratio ◽  
Age Related ◽  
Breast Lumps

Aims and Objectives: Breast lumps are quite common, but the principal issue is differentiating malignant from the benign sub-groups. The determinants of histologic diagnosis are multifactorial, ranging from environmental, genetic to sex and age-related factors. This study aimed to document the spectrum of breast lumps in our environment.Materials and Methods: This is a descriptive prospective analysis of consecutive breast lumps biopsied at Federal Teaching Hospital Abakaliki, between December 2010 to November 2012. The data were analysed using statistical package for social sciences (SPSS) version 22.0Results: A total of 302 patients with 359 breast lumps were seen, 298 females and 4 males giving male: female ratio of 1:75.The ages of the patients ranged between 16-82 years with a mean of 37.0 +/- SD 13.0. Majority (56.3%) of the patients had benign lumps. Fibroadenoma was the commonest (33.8%), followed closely by invasive ductal carcinoma (32.8%), then fibrocystic change (17.2%).The occurrence of breast cancer was strongly age-related, being 1 in 5 biopsies at 20-29 years and 3 in 5 biopsies at 40-49 years age groups. Over two-third (69.0%) of 132 patients with breast cancers were premenopausal. Majority (78.8%) of the 132 patients with breast cancer presented with advanced disease. At a median follow up of 9 months,13 (9.8%) and 6(4.5%) of 132 cancer patients developed recurrences and new cancer sites respectively.Conclusion: Most patients with breast complaints present with lumps and majority are benign, fibroadenoma being the commonest histology. Occurrence of breast cancer is strongly age-related with majority of cancer patients presenting late.Asian Journal of Medical Sciences Vol. 7(3) 2016 58-64

scholarly journals Synchronous Ovarian and Breast Cancers with a Novel Variant in BRCA2 Gene: A Case Report

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Néstor Llinás-Quintero ◽  
Eduardo Cabrera-Florez ◽  
Gustavo Mendoza-Fandiño ◽  
Gustavo Matute-Turizo ◽  
Elsa M. Vasquez-Trespalacios ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Response ◽  
Brca2 Gene ◽  
Radical Mastectomy ◽  
Genetic Profile ◽  
Breast Cancers ◽  
Complete Clinical Response ◽  
Histologic Diagnosis ◽  
Colon Cancers ◽  
Novel Variant

We report a case of a 52-year-old female with a family history of pancreatic and colon cancers who presented with a right breast mass positive for high-grade medullar carcinoma with triple-negative biomolecular profile. Further workup was performed finding a left ovarian mass. The patient underwent laparotomy performing optimal cytoreduction on bilateral ovarian tumors; the pathology and immunohistochemistry confirmed bilateral ovary adenocarcinoma with positive peritoneal malignancy. Due to her synchronic breast and ovarian cancers, a genetic profile was performed detecting a new pathogenic variant in the BRCA2 gene: c.3606_3607del (p.Ser1203Cysfs). She was given chemotherapy with carboplatin and paclitaxel obtaining complete clinical response. Regarding her breast cancer, she had a right modified radical mastectomy and prophylactic left mastectomy obtaining complete clinical response. This case presents with an unusual subtype and difficult histologic diagnosis of a synchronic medullar breast cancer and ovary carcinoma associated with a new mutation of the BRCA2 gene.

INCIDENCE OF BREAST CARCINOMA IN PREGNANT AND LACTATING WOMEN

2021 ◽  
pp. 46-47
Author(s):  
Dilpreet Kaur ◽  
Reena Jain ◽  
Sunita Rai ◽  
K.S Mangal
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Breast Cancers ◽  
Histopathological Correlation ◽  
Pregnancy And Lactation ◽  
Common Etiology ◽  
Lactating Females ◽  
Breast Lumps ◽  
A Prospective Study ◽  
In Pregnancy

INTRODUCTION: Breast lumps are a common problem encountered in pregnancy and lactation. These lumps are generally benign like broadenoma, lactating adenoma, mastitis and galactocele. Although rare the possibility of breast cancer (Pregnancy Associated Breast Cancer) should be considered, which is increasing in incidence nowadays. MATERIAL AND METHOD: A prospective study for 18 months was conducted on pregnant and lactating females for evaluating the role of cytology in interpretation of breast cancers. Clinical details, imaging ndings and histopathological correlation (wherever available) was also analyzed. RESULT: 85 breast lumps were identied and benign lesions were the most common etiology seen. Three cases were identied as pregnancy associated breast carcinoma (PABC) constituting 3.5% of all breast lumps. CONCLUSION: Cytology was an effective tool with minimal surgical intervention in identifying the etiology of breast masses in pregnancy and lactation. However, the cytopathologists must be aware of the characteristic patterns seen in breast FNAC smears during pregnancy and lactation and the associated atypia seen in glandular epithelium during this period. Breast carcinoma is the most common malignancy associated with pregnancy. The incidence is low but increasing due to late childbirth. Breast cancer during pregnancy has a similar prognosis to that of breast cancer in young.

scholarly journals The diagnostic performance of quantitative mapping in breast cancer patients: a preliminary study using synthetic MRI

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tiebao Meng ◽  
Ni He ◽  
Haoqiang He ◽  
Kuiyuan Liu ◽  
Liangru Ke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diagnostic Performance ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Benign Lesions ◽  
Quantitative Mapping ◽  
Quantitative Metrics ◽  
Preliminary Study ◽  
T1 And T2 ◽  
Synthetic Mri

Abstract Background Previous studies have indicated that quantitative MRI (qMR) is beneficial for diagnosis of breast cancer. As a novel qMR technology, synthetic MRI (syMRI) may be advantageous by offering simultaneous generation of T1 and T2 mapping in one scan within a few minutes and without concern to the deposition of the gadolinium contrast agent in cell nucleus. In this study, the potential of quantitative mapping derived from Synthetic MRI (SyMRI) to diagnose breast cancer was investigated. Methods From April 2018 to May 2019, a total of 87 patients with suspicious breast lesions underwent both conventional and SyMRI before treatment. The quantitative metrics derived from SyMRI, including T1 and T2 values, were measured in breast lesions. The diagnostic performance of SyMRI was evaluated with unpaired Student’s t-tests, receiver operating characteristic curve analysis and multivariate logistic regression analysis. The AUCs of quantitative values were compared using Delong test. Results Among 77 patients who met the inclusion criteria, 48 were diagnosed with histopathological confirmed breast cancers, and the rest had benign lesions. The breast cancers showed significantly higher T1 (1611.61 ± 215.88 ms) values and lower T2 (80.93 ± 7.51 ms) values than benign lesions. The area under the ROC curve (AUC) values were 0.931 (95% CI: 0.874–0.989) and 0.883 (95% CI: 0.810–0.956) for T1 and T2 maps, respectively, in diagnostic discrimination between breast cancers and benign lesions. A slightly increased AUC of 0.978 (95% CI: 0.915–0.993) was achieved by combining those two relaxation-based quantitative metrics. Conclusion In conclusion, our preliminary study showed that the quantitative T1 and T2 values obtained by SyMRI could distinguish effectively between benign and malignant breast lesions, and T1 relaxation time showed the highest diagnostic efficiency. Furthermore, combining the two quantitative relaxation metrics further improved their diagnostic performance.

Comparison of two laser Doppler flowmetry systems for bone blood flow analysis

1988 ◽  
Vol 43 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Marc F. Swiontkowski ◽  
Frank Schlehr ◽  
Jerry C. Collins ◽  
Roy Sanders ◽  
Adrienne Pou
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Flow Analysis ◽  
Laser Doppler ◽  
Bone Blood Flow ◽  
Doppler Flowmetry ◽  
Blood Flow Analysis

scholarly journals Evaluation of breast symptoms with mammography and ultrasonography

2011 ◽  
Vol 1 (3) ◽  
Author(s):  
Emine Devolli Disha ◽  
Suzana Manxhuka Kerliu ◽  
Zana Baruti Gafurri ◽  
Valdete Topciu ◽  
Bukurije Zhubi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diagnostic Accuracy ◽  
Cancer Detection ◽  
Breast Cancer Detection ◽  
Study Group ◽  
Benign Lesions ◽  
Breast Lump ◽  
Female Patients ◽  
Breast Lumps

Introduction: Aim of the study was to discern which are more frequent symptoms presented in malign and benign masses diagnosed by mammography and ultrasonography.Methods: Our study group consisted of 546 female patients, with breast symptoms such as palpable lumps (40.8%), pain in the breast (26%), localized lumpiness or nodularity (13.7%), nipple retraction (11.2%), nipplebloody discharge (5.1%) and redness and swelling of the breast (3.1%). All 546 patients were examined by ultrasonography and mammography. Biopsy was performed according to the findings of mammography and ultrasonography.Results: In breast cancer detection ultrasonography showed an efficiency of 79.4% compared to 55.0% for mammography in detecting breast lump, in the case of nipple retraction mammography showed an efficiency of 89.1% compared to 80.4% for ultrasound, while the lowest efficiency for mammography was in the cases with localized lumpiness or nodularity 17.1% compared to 45.7% for ultrasound. In detecting fibrocystic changes where the most common symptoms was pain, ultrasonography showed an efficiency of 99.3 % compared to 84.2 % for mammography.Conclusions: Our study confirmed that breast lumps are detectable in the majority of patients with breast cancer. The most frequent symptoms in patient with benign lesions were pain or localized discomfort. The diagnostic accuracy for carcinomas of the breast and for benign lesions according to symptoms was higher for ultrasound than for mammography.

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