The Role of Fine Needle Aspiration Cytology in the Diagnosis of Lesions of the Head and Neck excluding the Thyroid and Salivary Glands

1992 ◽  
Vol 78 (2) ◽  
pp. 134-136 ◽  
Author(s):  
Marina Suheko Oyafuso ◽  
Adhemar Longatto Filho ◽  
Mauro Kasuo Ikeda
Keyword(s):  
Head And Neck ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
True Negative ◽  
Predictive Values ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Fine-needle aspiration cytology (FNAC) was performed in 273 cases with suspicious masses of the head and neck, excluding the thyroid and salivary gland, at the A.C. Camargo Hospital from 1983 to 1989. The most frequently punctured site was the lymph nodes (n = 178), and the most common histologic diagnosis of malignancy was squamous cell carcinoma (n = 43). FNAC results were: 105 positive, 6 suspicious, 135 negative, and 27 unsatisfactory cases. There was a correlation between cytology and histology in 217 cases, with 102 true-positive, 76 true-negative, 1 false-positive, and 7 false-negative cases. Suspicious and unsatisfactory cases were not considered for this index. Analysis of the results showed an efficiency of 95.6%, sensitivity of 93.5%, and specificity of 98.7 %. Positive and negative predictive values were respectively 99.0 % and 91.5 %.

scholarly journals Discordance between fine-needle aspiration cytology and histopathology in patients with mucoepidermoid carcinoma of parotid gland

2020 ◽  
Vol 102 (5) ◽  
pp. 340-342
Author(s):  
H Iftikhar ◽  
M Sohail Awan ◽  
M Usman ◽  
A Khoja ◽  
W Khan
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Mucoepidermoid Carcinoma ◽  
False Negative ◽  
Needle Aspiration ◽  
True Positive ◽  
Aspiration Cytology ◽  
True Negative ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Introduction Fine-needle aspiration cytology (FNAC) is an important diagnostic tool used preoperatively for the diagnosis of parotid lump. Mucoepidermoid carcinoma comprises 5–10% of all salivary gland tumours. It poses a diagnostic challenge on FNAC with high false negative rate. The objective of this study was to evaluate the discordance between cytology/FNAC and histopathology in patients with mucoepidermoid carcinoma. Material and methods A cross-sectional study was conducted from 1 January 2010 to 31 December 2014. Patients aged 18 years and above with FNAC or histopathology suggestive of mucoepidermoid carcinoma were identified. FNAC when compared with histology (gold standard) was classified into true positive (presence of mucoepidermoid carcinoma correctly diagnosed on FNAC), true negative (absence of mucoepidermoid carcinoma correctly diagnosed on FNAC), false positive (FNAC incorrectly diagnosed mucoepidermoid carcinoma), false negative (FNAC failed to diagnose mucoepidermoid carcinoma). Results A total of 16 patients fulfilled our eligibility criteria. Seven cytological samples were true positive (ie correctly diagnosed mucoepidermoid carcinoma by FNAC), eight cytological specimens were false negative (ie could not pick up mucoepidermoid carcinoma on FNAC). One case was false positive on cytology (ie diagnosed mucoepidermoid carcinoma on FNAC but was reported to be Warthin’s tumour on histopathology) and none were true negative. Conclusion FNAC is not reliable for diagnosis of mucoepidermoid carcinoma. More than 50% of our patients had discordant results between cytology and histology. We recommend a high index of suspicion for mucoepidermoid carcinoma given the poor yield of cytology.

Fine needle aspiration cytology of salivary gland lesions reported immediately in a head and neck clinic

1993 ◽  
Vol 107 (11) ◽  
pp. 1025-1028 ◽  
Author(s):  
N. J. Roland ◽  
A. W. Caslin ◽  
P. A. Smith ◽  
L. S. Turnbull ◽  
A. Panarese ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Head And Neck ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Neck Surgery ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

AbstractThis paper describes the application of fine needle aspiration cytology (FNAC) performed on92 patients with salivary gland lesions in a Head and Neck Surgery Clinic. The aspirates were immediately reported by a cytopathologist and the reports conveyed to the surgeon during the same clinic visit. FNAC results were then compared with histology in those patients who underwent surgery and with the clinical course of the disease at subsequent clinic visits in patients where surgery was not performed. The cytological diagnosis was incorrect in five cases, one of which was a false negative result. There were no false positive results. The sensitivity was 90.9 per cent and the specificity 100 per cent. This rapid report system of fine needle aspiration cytology has been found to be safe, free of complications, and helpful in the planning of treatment.

Clinical analysis of false-negative fine needle aspiration cytology of head and neck cancers

2018 ◽  
Vol 131 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Seiji Hosokawa ◽  
Satoru Takebayashi ◽  
Yutaka Sasaki ◽  
Yuuki Nakamura ◽  
Kazuya Shinmura ◽  
...  
Keyword(s):  
Head And Neck ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Clinical Analysis ◽  
Head And Neck Cancers ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm

2014 ◽  
Vol 19 (2) ◽  
pp. 110-118
Author(s):  
Mohammad Amzad Hossain ◽  
Md Zahedul Alam ◽  
Md Rojibul Haque ◽  
Md Nazmul Haque ◽  
KM Nurul Alam ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Preoperative Diagnostic ◽  
Needle Aspiration Cytology

Objective: To evaluate the role of Fine Needle Aspiration Cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Methods: This cross sectional study on 50 cases was conducted in the Department of Otolaryngology and Head-Neck Surgery of Sir Salimullah Medical College Mitford Hospital and Dhaka Medical College Hospital from January’2009 to June 2010. Results: Fine needle aspiration cytology findings of our all 50 cases were compared with postoperative histopathological reports. Out of the 50 cases, in 36(72%) cases of benign neoplasm and 7(14%) cases of malignant neoplasm, pre-operative FNAC findings and post operative histopathological findings were same. In 7 cases, FNAC and post operative histopathological findings did not matched. These were 2 (4%) false positive and 5 (10%) false negative result.In our study sensitivity of FNAC for reporting malignancy was 58.33%, specificity to rule out malignancy was 94.73% and overall accuracy in detecting malignant tumour was 86%. Positive predictive value and negative value were 77.77% and 87.80% respectively. It can be concluded that fine needle aspiration cytology is a safe, cheap and useful preoperative diagnostic tool in the diagnosis of malignancy in parotid and submandibular gland, but as fine needle aspiration cytology partly depends on operator skill, it may give false negative and false positive result. Conclusion: FNAC is a useful preoperative diagnostic tool for malignant parotid and submandibular glands with high specificity and sensitivity. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2): 110-118

Fibroadenoma Mimicking Papillary Carcinoma on ThinPrep of Fine-Needle Aspiration of the Breast

2000 ◽  
Vol 124 (11) ◽  
pp. 1667-1669
Author(s):  
Timothy Myers ◽  
Helen H. Wang
Keyword(s):  
Fine Needle Aspiration ◽  
Stromal Cells ◽  
Fine Needle Aspiration Cytology ◽  
Smooth Muscle Actin ◽  
Single Cells ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Abstract Objective.—To compare and contrast benign and malignant lesions of the breast that have similar appearances on fine-needle aspiration cytology and that constitute diagnostic pitfalls. Design.—The cytology files (dated November 1995 through May 1998) of the Beth Israel Deaconess Medical Center were searched to identify cases of breast fine-needle aspiration biopsies that were highly cellular and composed of bland-appearing spindle/columnar cells and that could represent either epithelial or stromal cells; these cases were reported as indeterminate (atypical/suspicious) and had subsequent excisional biopsies taken. Results.—Four such cases were found. Two were fibroadenomas and 2 were papillary carcinomas. Their appearances were strikingly similar on aspiration cytology. All cases were prepared with the ThinPrep method. On microscopic examination, all 4 cases were hypercellular and had many single cells and clusters of columnar/elongate cells. Immunocytochemistry proved these cells to be of epithelial origin. At least occasional bipolar stromal cells were seen in the background. The only appreciable difference between the benign and malignant cases was more significant nuclear atypia, which was barely discernible, in the malignant cases. Immunocytochemistry for smooth muscle actin was helpful in 2 cases that had sufficient material. Conclusions.—Some cases of fibroadenomas and papillary carcinomas can be very difficult, if not impossible, to distinguish on fine-needle aspiration cytology. Immunocytochemistry may be helpful if sufficient material is available. To avoid false-negative or false-positive diagnosis on cytology, it is best to report such cases as atypical or suspicious with final diagnosis pending excisional biopsy.

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