scholarly journals Acute Dapsone Overdose: The Effects of Continuous Veno-Venous Haemofiltration on the Elimination of Dapsone

2011 ◽  
Vol 39 (6) ◽  
pp. 1131-1135 ◽  
Author(s):  
V. A. Masurkar ◽  
M. D. Edstein ◽  
C. J. Gorton ◽  
C. M. Anstey
Keyword(s):  
Methylene Blue ◽  
Ascorbic Acid ◽  
Renal Replacement Therapy ◽  
Lactic Acidosis ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Activated Charcoal ◽  
Multiple Dose ◽  
Good Outcome ◽  
Intentional Ingestion

A 15-year-old girl presented after intentional ingestion of dapsone (7.2 g) and small quantities of azathioprine, methotrexate and prednisolone. The resulting methaemoglobinaemia and lactic acidosis persisted despite treatment with methylene blue, multiple-dose activated charcoal and ascorbic acid. Continuous veno-venous haemofiltration for 75 hours was used to treat the dapsone overdose. The patient's serum dapsone concentrations were measured during and after continuous veno-venous haemofiltration. The rate of elimination of dapsone was over three times higher during, compared to after, continuous veno-venous haemofiltration. Continuous renal replacement therapy successfully reduced toxic dapsone concentrations in this patient with a good outcome.

Metformin-associated lactic acidosis treated with continuous renal replacement therapy

2006 ◽  
Vol 28 (3) ◽  
pp. 396-400 ◽  
Author(s):  
Polichronis Alivanis ◽  
Ioannis Giannikouris ◽  
Christos Paliuras ◽  
Antonios Arvanitis ◽  
Maria Volanaki ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Lactic Acidosis ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy

Toxicokinetics of metformin-associated lactic acidosis with continuous renal replacement therapy

2012 ◽  
Vol 37 (4) ◽  
pp. 249-253 ◽  
Author(s):  
Muhammad Mujtaba ◽  
Abdallah Sassine Geara ◽  
Machaiah Madhrira ◽  
Rajesh Agarwala ◽  
Herman Anderson ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Lactic Acidosis ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy

scholarly journals Metformin-associated lactic acidosis treated with continuous renal replacement therapy

2017 ◽  
pp. bcr2016218318 ◽  
Author(s):  
Akihide Nakamura ◽  
Kei Suzuki ◽  
Hiroshi Imai ◽  
Naoyuki Katayama
Keyword(s):  
Renal Replacement Therapy ◽  
Lactic Acidosis ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy

scholarly journals Systematic review of methemoglobinemia in acetaminophen poisoning

QJM ◽  
2020 ◽  
Author(s):  
K K Sahu ◽  
S V George ◽  
A D Siddiqui
Keyword(s):  
Systematic Review ◽  
Methylene Blue ◽  
Ascorbic Acid ◽  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Multiorgan Failure ◽  
The Other ◽  
Contaminated Water ◽  
Study Cohort ◽  
Emergency Physicians

Abstract Acetaminophen (N-acetyl-p-aminophenol paracetamol (APAP)) toxicity is one of the commonly encountered poisonings by emergency physicians. Methemoglobinemia is an uncommon association and rarely seen in APAP poisoning. The study involves the retrospective analysis of all the published reports on APAP-induced methemoglobinemia from 1968 to 2019. In total, there were 14 cases with nine females and six males. The median age of the study cohort was 59 years. The most common presenting feature was altered mentation (nine patients) followed by cyanosis (three patients). The intent of consumption was therapeutic (seven cases) vs. suicidal (five cases) attempt. In most cases, the dose of APAP consumption was not known. Aspirin, sulfasalazine, benzocaine spray, nitrate preservative, contaminated water, detergents, and so on where the other agents consumed by the patients in addition to APAP before developing methemoglobinemia. The median MethHb level of the study cohort was 15.85%. Patients were treated with NAC, hemodialysis, methylene blue and ascorbic acid and continuous renal replacement therapy in various combinations. Full recovery was seen in nine patients while four patients died. APAP toxicity is a well-known and a common entity with multiple sequelae that presents with a variable spectrum of mild to fulminant multiorgan failure. Awareness of non-classical presentations like methemoglobinemia is essential to ensure timely intervention.

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