scholarly journals Shivering Related to Epidural Blockade with Bupivacaine in Labour, and the Influence of Epidural Pethidine

1986 ◽  
Vol 14 (4) ◽  
pp. 412-417 ◽  
Author(s):  
P. Brownridge
Keyword(s):  
Nitrous Oxide ◽  
Initial Dose ◽  
Associated Factors ◽  
Intramuscular Injection ◽  
Epidural Block ◽  
Double Blind Trial ◽  
Double Blind ◽  
Prospective Survey ◽  
Epidural Blockade ◽  
Epidural Bupivacaine

A prospective survey of two hundred patients who received an epidural block in labour was performed in order to determine the incidence and severity of shivering, and the influence of likely associated factors. Twenty-two of the patients who shivered took part in a double-blind trial to see if epidural pethidine 25 mg, versus saline, had any effect upon shivering. Fifty per cent of patients shivered soon after the initial dose of bupivacaine. Shivering was more common among patients who had experienced shivering before epidural block, and in those who had received nitrous oxide (P<0.005). Prior intramuscular injection of pethidine did not significantly affect the incidence of shivering, and it was not influenced by the concentration of epidural bupivacaine used (0.5 or 0.25%). Shiverers were more likely to feel cold than non- shiverers (P<0.001) but shivering was generally regarded by patients as a trivial symptom, only 13 % describing it as very irritating. Shivering was abolished or considerably diminished within ten minutes in all patients who received epidural pethidine 25 mg, whereas there was no change in eight out of eleven patients who received epidural saline. These results are significant (P<0.01), and demonstrate that shivering following epidural blockade can be effectively treated with small epidural doses of pethidine.

scholarly journals A Double Blind Comparison of Alfentanil and Fentanyl

1985 ◽  
Vol 13 (1) ◽  
pp. 5-11
Author(s):  
H. Liberman ◽  
D. A. Pybus ◽  
T. A. Torda
Keyword(s):  
Nitrous Oxide ◽  
Computer Model ◽  
Half Life ◽  
Elective Surgery ◽  
Treated Group ◽  
Double Blind Trial ◽  
Double Blind ◽  
Elimination Half ◽  
Blind Comparison ◽  
Fentanyl Group

Alfentanil and fentanyl were compared as supplements to thiopentone, nitrous oxide, relaxant anaesthesia in a randomised, double blind trial carried out on 55 adult patients undergoing elective surgery. The fentanyl-treated patients resumed spontaneous ventilation more rapidly at the end of anaesthesia (3 minutes) than the alfentanil-treated group (5.1 minutes, p < 0.02). In other respects the drugs appeared indistinguishable. A computer model is used to explain why, despite the shorter elimination half-life, the alfentanil-treated patients did not awaken more rapidly than those in the fentanyl group.

A DOUBLE-BLIND TRIAL OF PATIENT-CONTROLLED NITROUS-OXIDE/OXYGEN ANALGESIA IN MYOCARDIAL INFARCTION

1976 ◽  
Vol 20 (4) ◽  
pp. 336
Author(s):  
F. KERR ◽  
M. G. BROWN ◽  
J. B. IRVING ◽  
M. R. HOSKINS ◽  
D. J. EWING ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Nitrous Oxide ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Nitrous Oxide Oxygen

A DOUBLE-BLIND TRIAL OF PATIENT- CONTROLLED NITROUS-OXIDE/OXYGEN ANALGESIA IN MYOCARDIAL INFARCTION

The Lancet ◽  
1975 ◽  
Vol 305 (7922) ◽  
pp. 1397-1400 ◽  
Author(s):  
F. Kerr ◽  
MyraG. Brown ◽  
J.B. Irving ◽  
MarionR. Hoskins ◽  
D.J. Ewing ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Nitrous Oxide ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Nitrous Oxide Oxygen

Epidural Bupivacaine-Dexmedetomidine versus Bupivacaine-Fentanyl for Anesthesia in Knee Surgeries

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Sahar Kamal Mohamed Abo Elela ◽  
Dalia Abd Elhamid Nasr ◽  
Maha Sadek Elderh ◽  
Karim Mohamed Salah Elgawish
Keyword(s):  
Epidural Anesthesia ◽  
Epidural Block ◽  
University Hospital ◽  
Sensory Level ◽  
Inclusion Criteria ◽  
Double Blind ◽  
Randomized Clinical Study ◽  
Epidural Bupivacaine ◽  
Prolonged Duration ◽  
Operating Theatres

Abstract Background Epidural anesthesia is one of the preferred modes of regional anesthesia for lower limb orthopedic surgeries. This technique provides not only peri-operative anesthesia but also post-operative analgesia. Bupivacaine is commonly used local anesthetic in epidural anesthesia, many adjuvants added to local anesthetics to enhance the quality and duration of surgical anesthesia, among them are opioids, alpha 2 agonists. Opioids like fentanyl have been a popular choice, it offers faster onset and prolongs the duration of analgesia. Recently, alpha 2 agonists like clonidine and dexmedetomidine have been also used in prolonging the duration of epidural analgesia. Aim of the Work To compare the efficacy of using fentanyl and dexmedetomidine with bupivacaine in epidural block for knee surgeries, the time of onset of sensory, motor blockade and the duration of this blockade. Patients and Methods After obtaining approval from the Research Ethical Committee of Ain Shams University, this study was conducted in the operating theatres of Ain Shams University Hospital. It was a prospective double-blind randomized clinical study. Study period was 6 months. Results A total of 50 patients out of 71 consecutive patients met the inclusion criteria and consented for study. These 50 patients were randomized into two groups of 25 each. Out of the total patients, 33 were male and 17 were female. Conclusion Dexmedetomidine as an adjuvant to epidural bupivacaine is a better alternative to fentanyl as it shows faster onset of sensory and motor block, lesser time to attain maximum sensory level and prolonged duration of anesthesia.

99: Prulifloxacin Versus Levofloxacin in the Treatment of Chronic Bacterial Prostatitis: A Prospective, Randomized, Double-Blind Trial

2007 ◽  
Vol 177 (4S) ◽  
pp. 35-35
Author(s):  
Gianluca Giannarini ◽  
Andrea Mogorovich ◽  
Girolamo Morelli ◽  
Maurizio De Maria ◽  
Francesca Manassero ◽  
...  
Keyword(s):  
Double Blind Trial ◽  
Chronic Bacterial Prostatitis ◽  
Double Blind ◽  
Blind Trial ◽  
Bacterial Prostatitis

Acute Deep Vein Thrombosis Treated with Porcine Plasmin

1974 ◽  
Vol 32 (02/03) ◽  
pp. 468-482 ◽  
Author(s):  
O Storm ◽  
P Ollendorff ◽  
E Drewsen ◽  
P Tang
Keyword(s):  
Deep Vein Thrombosis ◽  
Lower Limb ◽  
Initial Dose ◽  
Treated Group ◽  
Allergic Reactions ◽  
Double Blind ◽  
Vein Thrombosis ◽  
Thrombolytic Effect ◽  
Acute Deep Vein Thrombosis ◽  
Deep Vein

SummaryThe thrombolytic effect of pig plasmin was tested in a double blind trial on patients with deep venous thrombosis in the lower limb. Only patients with not more than three days old thrombi were selected for this study. The diagnosis of deep vein thrombosis was made clinically and confirmed by phlebography. Lysofibrin Novo (porcine plasmin) or placebo (porcine plasminogen) was administered intravenously to the patients. The enzyme and the placebo were delivered as lyophilized powder in labelled bottles - the contents of the bottles were unknown to the doctor in charge of the clinical administration of the trial. An initial dose of plasmin/plasminogen of 30 unit per kg body weight given slowly intravenously (1-1% hours infusion) was followed by a maintenance dosis of 15 per cent the initial dose per hour for the following 5-7 hours. In most cases a similar maintenance dosis was given the next day. In all patients heparin was administered after ending the plasmin/plasminogen infusion. The results of the treatment was evaluated clinically as well as by control phlebo- grams the following days.A statistically significant improvement was found in the plasmin treated group compared with the placebo (plasminogen) treated group. Thrombolysis was obtained clinically and phlebographically in 65 per cent of the plasmin treated group, but only in 15 per cent of the control patients were improvements found.This study has thus demonstrated that plasmin treatment according to a standard scheme was able to induce thrombolysis. There were only a few and insignificant side effects. Allergic reactions have not been seen and only very simple tests are required.

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