Peripheral intravenous catheter complications in critically ill children: a prospective study JS GARLAND, WM DUNNE JR, P HAVENS, ET AL Department of Pediatrics and Department of Pathology, Medical College of Wisconsin and Department of Nursing, Children's Hospital of Wisconsin, Milwaukee

1993 ◽  
Vol 8 (2) ◽  
pp. 78-78
Author(s):  
Beth Lyman
Keyword(s):  
Prospective Study ◽  
Critically Ill ◽  
Critically Ill Children ◽  
Intravenous Catheter ◽  
Children's Hospital ◽  
Medical College ◽  
Children’S Hospital ◽  
Peripheral Intravenous Catheter ◽  
Catheter Complications ◽  
A Prospective Study

A prospective study of the adverse effects of midazolam on withdrawal in critically ill children

1994 ◽  
Vol 83 (11) ◽  
pp. 1194-1199 ◽  
Author(s):  
J. Hughes ◽  
A. Gill ◽  
HJ Leach ◽  
AJ Nunn ◽  
I. Billingham ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Prospective Study ◽  
Critically Ill ◽  
Critically Ill Children ◽  
A Prospective Study

scholarly journals Clinical Application of Whole Exome Sequencing for Monogenic Disorders in PICU of China

2021 ◽  
Vol 12 ◽  
Author(s):  
Yingchao Liu ◽  
Chanjuan Hao ◽  
Kechun Li ◽  
Xuyun Hu ◽  
Hengmiao Gao ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Critically Ill ◽  
Whole Exome Sequencing ◽  
Critically Ill Children ◽  
Human Phenotype ◽  
Children's Hospital ◽  
Monogenic Disorders ◽  
Whole Exome ◽  
Monogenic Diseases ◽  
Children’S Hospital

ObjectivesWhole exome sequencing (WES) has been widely used to detect genetic disorders in critically ill children. Relevant data are lacking in pediatric intensive care units (PICUs) of China. This study aimed to investigate the spectrum of monogenic disorders, the diagnostic yield and clinical utility of WES from a PICU in a large children’s hospital of China.MethodsFrom July 2017 to February 2020, WES was performed in 169 critically ill children with suspected monogenic diseases in the PICU of Beijing Children’s Hospital. The clinical features, human phenotype ontology (HPO) terms, and assessment of clinical impact were analyzed.ResultsThe media age of the enrolled children was 10.5 months (range, 1 month to 14.8 years). After WES, a total of 43 patients (25%) were diagnosed with monogenic disorders. The most common categories of diseases were metabolic disease (33%), neuromuscular disease (19%), and multiple deformities (14%). The diagnosis yield of children with “metabolism/homeostasis disorder” and “growth delay” or “ocular anomalies” was higher than that of children without these features. In addition, the diagnosis rate increased when more features were observed in children. The results of WES had an impact on the treatment for 30 cases (70%): (1) change of treatment (n = 11), (2) disease monitoring initiation (n = 18), (3) other systemic evaluation (n = 3), (4) family intervention (n = 2), and (5) rehabilitation and redirection of care toward palliative care (n = 12).ConclusionWES can be used as an effective diagnostic tool in the PICU of China and has an important impact on the treatment of patients with suspected monogenic conditions.

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