Clinical Applications of Therapeutic Hemapheresis

1996 ◽  
Vol 11 (3) ◽  
pp. 149-161 ◽  
Author(s):  
Sarah Rososhansky ◽  
Irma O. Szymanski
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Clinical Applications ◽  
Goodpasture's Syndrome ◽  
Thrombocytopenic Purpura ◽  
Technical Aspects ◽  
Prompt Treatment ◽  
Life Saving

Therapeutic hemapheresis may be a life-saving treatment for patients with some diseases, such as thrombotic thrombocytopenic purpura (TTF), Goodpasture's syndrome, and leukemia-induced leukocytosis, among others. Although plasma exchange has been applied for treatment of many conditions, during the last decade a consensus has been reached about the specific but limited number of diseases for which it is of definitive benefit. Some patients are severely ill during the course of the disease, and they require prompt treatment in the intensive care unit. Therapy of these patients is discussed in this review in detail, in addition to technical aspects, indications, contraindications, and complications of therapeutic hemapheresis.

Plasma exchange in the intensive care unit: Technical aspects and complications

2017 ◽  
Vol 32 (6) ◽  
pp. 405-412 ◽  
Author(s):  
Aurélie Lemaire ◽  
Nathalie Parquet ◽  
Lionel Galicier ◽  
David Boutboul ◽  
Rémi Bertinchamp ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Plasma Exchange ◽  
Technical Aspects

scholarly journals Thrombotic Thrombocytopenic Purpura: What an Intensive Care Unit Doctor Needs to Know

Cureus ◽  
2020 ◽  
Author(s):  
Arian Bethencourt-Mirabal ◽  
Daylin Rodriguez Cesar ◽  
Dalie Ortet ◽  
Felix Hernandez ◽  
Gustavo Ferrer
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

Response to Plasma Exchange and Steroids as Combined Therapy for Patients with Thrombotic Thrombocytopenic Purpura

1999 ◽  
Vol 102 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Javier de la Rubia ◽  
Aurelio López ◽  
Francisco Arriaga ◽  
Ana Rosa Cid ◽  
Ana Isabel Vicente ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Combined Therapy ◽  
Thrombocytopenic Purpura

scholarly journals A Signet Ring Cell Carcinoma Presented as Refractory Acquired Thrombotic Thrombocytopenic Purpura

2020 ◽  
Vol 13 (3) ◽  
pp. 1368-1372
Author(s):  
Umit Yavuz Malkan ◽  
Murat Albayrak ◽  
Hacer Berna Ozturk ◽  
Merih Reis Aras ◽  
Bugra Saglam ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Unknown Origin ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Thrombocytopenic Purpura ◽  
Signet Ring ◽  
Gastric Endoscopy ◽  
Ring Cell

Microangiopathic hemolytic anemia (MAHA) can be observed as a paraneoplastic syndrome (PS) in certain tumors. MAHA-related signet ring cell carcinoma (SRCC) of an unknown origin is very infrequent. Herein we present a SRCC case presented with refractory acquired thrombotic thrombocytopenic purpura (TTP). A 35-year-old man applied to the emergency service with fatigue and headache. His laboratory tests resulted as white blood cell 9,020/µL, hemoglobin 3.5 g/dL, platelet 18,000/µL. Schistocytes, micro-spherocytes, and thrombocytopenia were observed in his blood smear. MAHA was present and he was considered as having TTP. Plasma exchange treatment was initiated; however, he was refractory to this treatment. Thorax and abdomen computerized tomography revealed thickening of minor curvature in stomach corpus with hepatogastric and paraceliac lymphadenopathy. Bone marrow (BM) investigation by our clinic resulted as the metastasis of adenocarcinoma. Ulceration and necrosis were observed by gastric endoscopy procedure. Biopsy was taken during endoscopic intervention, which resulted as SRCC. MAHA may be seen as a PS in some tumors, especially gastric cancers. Tumor-related MAHA is generally accompanied by BM metastases. As a result, BM investigation may be used as the main diagnostic method to find the underlying cancer. The clinical course of cases with tumor-related MAHA is usually poor, and these cases are usually refractory to plasma exchange treatment. In conclusion, physicians should suspect a malignancy and BM involvement when faced with a case of refractory TTP.

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