Statins, Enzyme CoQ10 Supplement Use, and Cognitive Functioning

2021 ◽  
pp. 089198872110447
Author(s):  
Brian G. Collin ◽  
Dheeraj Raju ◽  
Steven Katsikas
Keyword(s):  
Cognitive Functioning ◽  
Test Performance ◽  
Neuropsychological Test ◽  
Verbal Learning ◽  
Prevention Study ◽  
Wechsler Memory Scale ◽  
Supplement Use ◽  
Auditory Verbal Learning ◽  
Medical Histories ◽  
Learning Test

Objective: The current study assessed the effects of statin and CoQ10 supplement use on changes in cognitive functioning in the Wisconsin Registry for Alzheimer’s Prevention study. Methods: 1,573 subjects were administered medical histories, the Mini-Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), Wechsler Memory Scale, Logical Memory subtest, and the Trail Making Test, Parts A (TMT-A) and B (TMT-B) 3-4 times over 5-10 years. Results: Linear mixed models did not yield significant effects for statin or CoQ10 supplement use on changes in mental status, learning and memory, psychomotor speed, and cognitive flexibility. Conclusions: Statin and/or CoQ10 supplement use was not associated with neuropsychological test performance in the Wisconsin Registry for Alzheimer’s Prevention study.

Comparing the Psychometric Properties of Eight Embedded Performance Validity Tests in the Rey Auditory Verbal Learning Test, Wechsler Memory Scale Logical Memory, and Brief Visuospatial Memory Test–Revised Recognition Trials for Detecting Invalid Neuropsychological Test Performance

Assessment ◽  
2020 ◽  
pp. 107319112092909
Author(s):  
Joshua I. Pliskin ◽  
Samantha DeDios Stern ◽  
Zachary J. Resch ◽  
Kevin F. Saladino ◽  
Gabriel P. Ovsiew ◽  
...  
Keyword(s):  
Test Performance ◽  
Neuropsychological Test ◽  
Verbal Learning ◽  
Neurocognitive Disorder ◽  
Performance Validity ◽  
Wechsler Memory Scale ◽  
Mild Neurocognitive Disorder ◽  
Auditory Verbal Learning ◽  
Learning Test ◽  
Validity Tests

This cross-sectional study evaluated eight embedded performance validity tests (PVTs) previously derived from the Rey Auditory Verbal Learning Test (RAVLT), Wechsler Memory Scale–IV–Logical Memory (LM), and Brief Visuospatial Memory Test–Revised (BVMT-R) recognition trials among a single mixed clinical sample of 108 neuropsychiatric patients (83 valid/25 invalid) with ( n = 54) and without ( n = 29) mild neurocognitive disorder. Among the overall sample, all eight recognition PVTs significantly differentiated valid from invalid performance (areas under the curve [AUCs] = .64-.81) with 26% to 44% sensitivity (≥89% specificity) at optimal cut-scores depending on the specific PVT. After subdividing the sample by cognitive impairment status, all eight PVTs continued to reliably identify invalid performance (AUC = .68-.91) with markedly increased sensitivities of 56% to 80% (≥89% specificity) in the unimpaired group. In contrast, among those with mild neurocognitive disorder, RAVLT False Positives and LM became nonsignificant, whereas the other six PVTs remained significant (AUC = .64-.77), albeit with reduced sensitivities of 32% to 44% (≥89% specificity) at optimal cut-scores. Taken together, results cross-validated BVMT-R and most RAVLT recognition indices as effective embedded PVTs for identifying invalid neuropsychological test performance with diverse populations including examinees with and without suspected mild neurocognitive disorder, whereas LM had more limited utility as an embedded PVT, particularly when mild neurocognitive disorder was present.

scholarly journals Cognitive decline affects diabetic women

2016 ◽  
Vol 17 (4) ◽  
pp. 272-274 ◽  
Author(s):  
Adam Perzyński ◽  
Iwona Chmiel-Perzyńska
Keyword(s):  
Motor Control ◽  
Cognitive Decline ◽  
Cognitive Functioning ◽  
Cognitive Functions ◽  
Verbal Learning ◽  
Apparent Lack ◽  
Auditory Verbal Learning ◽  
Trail Making ◽  
Learning Test ◽  
Underlying Mechanisms

AbstractIntroduction: DM provokes peripheral complications and changes in central nervous system. Central changes in the course of diabetes mellitus (DM) include changes in brain tissue structure, electrophysiological abnormalities but also disturbances in neurotransmission leading to cognitive decline.Aim of the study: The aim of our study was to asses cognitive functioning of patients suffering from DM1 for at least 5 years but without any diagnosed complications.Materials and methods: Cognitive functions were assessed in 59 patients (35 men) with Trail Making Test A (TMT A) and B (TMT B), Maze Test (MT), Stroop Test (SCWT) and Rey Auditory Verbal Learning Test (RAVLT). Mental disorders were excluded with Beck’s Depression Inventory (BT), Mini Mental State Examination (MMSE) and psychiatric examination.Results: We stated that women, compared with men, presented worsening of executive functions, speed and motor control. Cognitive decline depended on number of episodes of at least moderate hypoglycemia and duration of disease. HbA1c below 8% resulted in better memory, speed and motor control. Cognitive decline was more escalated in the patients with atherogenic lipid profile.Conclusions: It seems that even apparent lack of complications is not unambiguous with lack of cognitive decline and women seem to be more susceptible. DM1 affects young individuals, whose cognitive functions are in the course of the development, so it is important to find the underlying mechanisms and the areas of disturbed cognitive functioning and further investigations are needed.

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