Reproductive Function in Dialysis Patients: CAPD vs Hemodialysis

1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 30-32 ◽  
Author(s):  
Marilyn Galler ◽  
Bruce Spinowitz ◽  
Chaim Chary Tan ◽  
Mahesh Kabadi ◽  
Ruth Freeman

A variety of hormonal disturbances and reproductive abnormalities occur in women on chronic maintenance hemodialysis. Recently, it has been noted that, when transferred from hemodialysis to continuous ambulatory peritoneal dialysis (CAPD), some women have resumed normal menses with ovulatory cycles. We compared menstrual histories, vaginal hormonal smears and ovulatory curves in 12 women on hemodialysis vs. seven women on CAPD under the age of 45. Eightysix per cent of the CAPD patients and 25% of the hemodialysis patients had regular menses. Upon transfer to CAPD, two amenorrheic females resumed regular menses within 21 months. Only two patients (one in each group) had ovulatory cycles. All patients had a vaginal estrogen effect. The return of regular menses in CAPD patients may be due to improved middle-molecule clearances with secondary normalization of the hormonal imbalances.

2001 ◽  
Vol 25 (6) ◽  
pp. 448-452 ◽  
Author(s):  
Fatma Nurhan Ozdemir ◽  
Galip Guz ◽  
Siren Sezer ◽  
Zubeyde Arat ◽  
Munire Turan ◽  
...  

2002 ◽  
Vol 39 (6) ◽  
pp. 1292-1299 ◽  
Author(s):  
Gen Yasuda ◽  
Kazuhiko Shibata ◽  
Toshikazu Takizawa ◽  
Yumiko Ikeda ◽  
Yasuo Tokita ◽  
...  

1994 ◽  
Vol 4 (9) ◽  
pp. 1726-1732
Author(s):  
J M Burkart ◽  
B I Freedman ◽  
M V Rocco

Although it is well established that an increase in hematocrit results in a small decrease in solute transport in hemodialysis patients, the effect of hematocrit on solute transport in peritoneal dialysis patients remains controversial. In hemodialysis patients, the inverse relationship between hematocrit and the transport of small solutes may be explained by the dependence of solute clearance on the rapidity of solute movement from the red blood cell to the dialysate. This movement is determined by several in vivo factors, the most important of which is blood flow. However, in peritoneal dialysis, the effective peritoneal capillary blood flow is several times the maximal urea clearance. Therefore, clearances are usually considered to be independent of blood flow rate and variations in hematocrit should not affect solute transport across the peritoneal membrane. In this study, the effect of an increase in hematocrit on the transport of small solutes in peritoneal dialysis patients is analyzed. The peritoneal equilibration test was performed in 25 continuous ambulatory peritoneal dialysis patients before and after an increase in hematocrit of at least seven points. No significant change was found in ultrafiltration rate or in peritoneal transport characteristics as measured by the peritoneal equilibration test or by mass transfer area coefficients for creatinine, urea, or glucose. In addition, there was no change in these parameters in a control group of 13 continuous ambulatory peritoneal dialysis patients with no significant change in hematocrit. These findings are consistent with the observation that solute clearance for urea and creatinine in peritoneal dialysis is not blood flow dependent.(ABSTRACT TRUNCATED AT 250 WORDS)


1987 ◽  
Vol 10 (2) ◽  
pp. 72-76 ◽  
Author(s):  
S.M. Lal ◽  
K.D. Nolph ◽  
H. Hain ◽  
H.L. Moore ◽  
R. Khanna ◽  
...  

We measured total serum creatine kinase (CK) and serum creatine kinase MB fraction (CK-MB) in 53 patients on continuous ambulatory peritoneal dialysis (CAPD) and 52 patients on maintenance hemodialysis (HD), using Scalva UV methodology for CK and electrophoresis for CK-MB. Seven of the 53 CAPD patients (13%) had an elevated total CK, and only one of these 7 patients had an elevated CK-MB > 5%. In contrast 22 HD patients (42%) had increased total CK values, and 6 of these 22 HD patients (27%) showed elevated CK-MB isoenzyme > 5%. For each sex, blacks had higher mean CK values than whites. Twenty-one out of the 43 HD patients who received intramuscular injections had elevated total CK values and 6 of these 21 patients had elevated CK-MB isoenzyme independent of the timing of injection. The increased frequency of higher total CK values in HD patients appears to be related to race and androgen administration. The modest elevations in CK-MB fraction (5 to 8%) in these patients require careful interpretation.


2020 ◽  
Vol 5 (2) ◽  
pp. 2-9
Author(s):  
Abhishek Maskey ◽  
Navaraj Paudel ◽  
Subash Sapkota ◽  
Pooja Jha

Introduction: Cardiovascular disease is frequent in end-stage kidney disease patients, and is a major cause of morbidity and mortality. This study was carried out to assess the comparative cardiac effects of hemodialysis and continuous ambulatory peritoneal dialysis on left ventricular function.Methods: A prospective observational study was carried out in patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis at least for 6 months. The duration of the study was from June 2019 to May 2020. CAPD consists of 3 to 4 exchanges/day and haemodialysis 2-3 times/week for 4 hours. Baseline characteristics age, gender, dialysis duration, hypertension, diabetes and hyperlipidaemia were collected. The same cardiologist performed all echocardiography at the end of hemodialysis session in hemodialysis patients and after the drain of dialysate in peritoneal dialysis patients.Results: Sixty patients (40 hemodialyses, 20 peritoneal dialyses) were enrolled. The mean age of the patient was 53.71±13.00 years (range 25-76). There was a slightly higher number of male in the hemodialysis group (p= 0.065). Systolic and diastolic blood pressure were significantly higher in hemodialysis groups (p<0.001). Regarding left ventricular parameters, hemodialysis patients had a higher prevalence of left ventricular diastolic dysfunction, left ventricular hypertrophy, left ventricular mass compared to peritoneal dialysis patients. Pericardial effusion and thickening were present higher in hemodialysis patients and was statistically significant (p<0.05).Conclusion: The modality of dialysis influence left ventricular function. Left ventricle dysfunction is prevalent among hemodialysis patients compared to peritoneal dialysis. Echocardiographic follow up is essential as this could improve the management of cardiovascular complications in dialysis patients.


2009 ◽  
Vol 27 (1) ◽  
pp. 59-61
Author(s):  
E Indhumathi ◽  
V Chandrasekaran ◽  
D Jagadeswaran ◽  
M Varadarajan ◽  
G Abraham ◽  
...  

1980 ◽  
Vol 3 (4) ◽  
pp. 203-208
Author(s):  
B.T. Burton

Today, management of irreversible renal failure is based primarily on maintenance hemodialysis and renal transplantation with a growing minority of patients treated by peritoneal dialysis. With regard to renal transplantation — the early promise of renal transplantation in the mid 1960's has given way to the realities of the late 1970's. There have been no major changes in the rejection rate of transplanted kidneys in recent years though today's mortality of transplant patients is considerably reduced over what it used to be. Moreover, universally the lack of availability of a sufficient number of organs for transplantation poses a formidable problem. It is all too apparent that current methods of blood purification in uremia are far from optimal. Even though the mortality in maintenance dialysis is relatively low, hemodialysis is characterized by a variety of complications and most maintenance dialysis patients are not optimally rehabilitated.


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