Total Creatine Kinase and Isoenzyme Fractions in Chronic Dialysis Patients

1987 ◽  
Vol 10 (2) ◽  
pp. 72-76 ◽  
Author(s):  
S.M. Lal ◽  
K.D. Nolph ◽  
H. Hain ◽  
H.L. Moore ◽  
R. Khanna ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Serum Creatine Kinase ◽  
Chronic Dialysis ◽  
Maintenance Hemodialysis ◽  
Total Serum ◽  
Dialysis Patients ◽  
Creatine Kinase Mb ◽  
Total Creatine

We measured total serum creatine kinase (CK) and serum creatine kinase MB fraction (CK-MB) in 53 patients on continuous ambulatory peritoneal dialysis (CAPD) and 52 patients on maintenance hemodialysis (HD), using Scalva UV methodology for CK and electrophoresis for CK-MB. Seven of the 53 CAPD patients (13%) had an elevated total CK, and only one of these 7 patients had an elevated CK-MB > 5%. In contrast 22 HD patients (42%) had increased total CK values, and 6 of these 22 HD patients (27%) showed elevated CK-MB isoenzyme > 5%. For each sex, blacks had higher mean CK values than whites. Twenty-one out of the 43 HD patients who received intramuscular injections had elevated total CK values and 6 of these 21 patients had elevated CK-MB isoenzyme independent of the timing of injection. The increased frequency of higher total CK values in HD patients appears to be related to race and androgen administration. The modest elevations in CK-MB fraction (5 to 8%) in these patients require careful interpretation.

scholarly journals Influence of Gender on Total Serum Creatine Kinase and Creatine Kinase-Mb Levels of Nigerian Hypertensives

2021 ◽  
Vol 6 (2) ◽  
pp. 1436-1439
Author(s):  
Henry Afamuefuna Efobi ◽  
Iya Eze Bassey
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Creatine Kinase ◽  
Body Mass ◽  
The Body ◽  
Total Serum ◽  
Creatine Kinase Mb ◽  
Normotensive Subjects ◽  
Total Creatine ◽  
Gender Specific

Introduction: Hypertension is a long-term medical condition which when not detected and managed properly and on time often results to complications leading to disabilities and mortality. Gender has been known to affect the interpretation of some variables necessitating the need for gender-specific ranges. Objectives:This study evaluated total creatine kinase (CK) and creatine kinase-MB (CK-MB) isoenzyme activities of hypertensive subjects in Calabar, Nigeria and to assess if gender has influence on the activities of these enzymes. Methodology:One hundred and two participants were consecutively enrolled in this case control study. Serum total serum CK and CK-MB activity were evaluated in fifty one hypertensive and 51 normotensive subjects. The total CK levels were assessed using a spectrophotometric method while immunoinhibition method was used to determine the activity of CK-MB. Data was analyzed using Student’s t-test and Pearson’s correlation. Statistical significance was set at p<0.05. Results:The total creatine kinase activities of the hypertensives did not differ significantly from those of the normotensive controls (p = 0.428) while the serum CK-MB activities of the hypertensive subjects were significantly higher than those of the normotensive controls (p=0.000). The body mass index of the hypertensives was significantly higher than those of the normotensive subjects (p=0.030). Gender had no effect on the blood pressure, body mass index and levels of CK and CK-MB (p>0.05). There was also no significant correlation (p>0.05) between blood pressure, body mass index and the levels of CK and CK-MB. Conclusion:CK-MB activities were significantly higher in hypertensive subjects compared to normotensive controls. There were no gender specific differences in the CK-MB levels of male and female hypertensives. This cardiac marker should be included in the routine assessment of hypertensives and gender-specific considerations may not be necessary in the interpretation of the data.

Reproductive Function in Dialysis Patients: CAPD vs Hemodialysis

1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 30-32 ◽  
Author(s):  
Marilyn Galler ◽  
Bruce Spinowitz ◽  
Chaim Chary Tan ◽  
Mahesh Kabadi ◽  
Ruth Freeman
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Reproductive Function ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Dialysis Patients ◽  
Vaginal Estrogen ◽  
Regular Menses ◽  
Estrogen Effect

A variety of hormonal disturbances and reproductive abnormalities occur in women on chronic maintenance hemodialysis. Recently, it has been noted that, when transferred from hemodialysis to continuous ambulatory peritoneal dialysis (CAPD), some women have resumed normal menses with ovulatory cycles. We compared menstrual histories, vaginal hormonal smears and ovulatory curves in 12 women on hemodialysis vs. seven women on CAPD under the age of 45. Eightysix per cent of the CAPD patients and 25% of the hemodialysis patients had regular menses. Upon transfer to CAPD, two amenorrheic females resumed regular menses within 21 months. Only two patients (one in each group) had ovulatory cycles. All patients had a vaginal estrogen effect. The return of regular menses in CAPD patients may be due to improved middle-molecule clearances with secondary normalization of the hormonal imbalances.

scholarly journals Continuous Ambulatory Peritoneal Dialysis Is Superior to Hemodialysis in Chronic Dialysis Patients with Cerebral Hemorrhage

Nephron ◽  
1994 ◽  
Vol 67 (3) ◽  
pp. 365-366 ◽  
Author(s):  
Noriaki Yorioka ◽  
Hiroaki Oda ◽  
Takahiko Ogawa ◽  
Yoshihiko Taniguchi ◽  
Shigeyuki Kushihata ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Cerebral Hemorrhage ◽  
Chronic Dialysis ◽  
Dialysis Patients

Serum creatine kinase MM isoforms in hypertrophic cardiomyopathy

1991 ◽  
Vol 81 (6) ◽  
pp. 723-726 ◽  
Author(s):  
Mareomi Hamada ◽  
Takashi Ohtani ◽  
Michihito Sekiya ◽  
Yasushi Fujiwara ◽  
Takumi Sumimoto ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Hypertrophic Cardiomyopathy ◽  
Normal Control ◽  
Activity Ratio ◽  
Serum Creatine Kinase ◽  
Myocardial Tissue ◽  
Control Subjects ◽  
Creatine Kinase Mb ◽  
Total Creatine

1. To determine whether a persistent release of creatine kinase from the myocardium occurs in patients with hypertrophic cardiomyopathy, the activities of serum creatine kinase MM isoforms were measured in 22 patients with hypertrophic cardiomyopathy and in 14 normal control subjects. 2. Serum creatine kinase MB activity was significantly higher in patients with hypertrophic cardiomyopathy (7.8 ± 3.8 i.u./l) than in normal control subjects (0.4 ± 0.8 i.u./l; P < 0.01). 3. Serum MMa, MMb and MMc activities in patients with hypertrophic cardiomyopathy were 19.4 ± 4.1%, 26.7 ± 2.5% and 33.5 ± 7.0% of the total creatine kinase MM activity, respectively. These values for each isoform were significantly different from those in normal control subjects (11.3 ± 3.0%, 21.5 ± 4.4% and 40.7 ± 7.0%, respectively). The MMa/MMc activity ratio was significantly higher in patients with hypertrophic cardiomyopathy (0.61 ± 0.25) than in normal control subjects (0.30 ± 0.10; P < 0.01). 4. Our results indicate that a small amount of the myocardial tissue isoform of creatine kinase MM (MMa) is constantly released in many patients with hypertrophic cardiomyopathy.

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