Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk

2020 ◽  
Vol 32 (9) ◽  
pp. 1267-1274 ◽  
Author(s):  
Leslie Grasset ◽  
Roelof A. J. Smit ◽  
Michelle R. Caunca ◽  
Tali Elfassy ◽  
Michelle C. Odden ◽  
...  
Keyword(s):  
At Risk ◽  
Cognitive Function ◽  
Prospective Study ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
The Elderly ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Learning Test

Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person’s repeated measurements. Results: Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β [95% confidence interval] [CI] = −4.39 [−7.36, −1.43], p = .004), immediate recall on the 15-Picture Learning Test (β [95% CI] = −0.98 [−1.86, −0.11], p = .027), and delayed recall on the 15-Picture Learning Test (β [95% CI] = −1.90 [−3.14, −0.67], p = .002). The associations did not vary by treatment group. Discussion: Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults.

Low Levels of High-Density Lipoprotein Cholesterol Are a Marker of Disability in the Elderly

Gerontology ◽  
1999 ◽  
Vol 45 (6) ◽  
pp. 317-322 ◽  
Author(s):  
Giovanni Zuliani ◽  
Franco Romagnoni ◽  
Cristina Bollini ◽  
Vincenzo Leoci ◽  
Lucia Soattin ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
The Elderly ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Levels

scholarly journals Long-Term Increase in Cholesterol Is Associated With Better Cognitive Function: Evidence From a Longitudinal Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Huamin Liu ◽  
Lianwu Zou ◽  
Rui Zhou ◽  
Minyi Zhang ◽  
Shanyuan Gu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cognitive Function ◽  
High Density Lipoprotein ◽  
Cognitive Decline ◽  
High Density Lipoprotein Cholesterol ◽  
Memory Function ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol

Background: Higher visit-to-visit cholesterol has been associated with cognitive decline. However, the association between long-term increase or decrease in cholesterol and cognitive decline remains unclear.Methods: A total of 4,915 participants aged ≥45 years with normal cognition in baseline were included. The participants were divided into four groups, namely low–low, low–high, high–low, and high–high, according to the diagnostic thresholds of total cholesterol (TC), non-high-density lipoprotein cholesterol (NHDL-C), low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) after 4 years of follow-up. Cognitive function was assessed by episodic memory and mental intactness. Binary logistic regression was used to analyse the association of cholesterol variation with cognitive decline.Results: Among the participants, 979 (19.9%) experienced global cognitive decline. The odds ratio (OR) of global cognitive and memory function decline were remarkably lower in participants in the low–high NHDL-C group than those in the low–low group [OR and 95% confidence interval (CI): 0.50 [0.26–0.95] for global cognitive decline, 0.45 [0.25–0.82] for memory function decline]. The lower OR was also significant in females (OR [95% CI]: 0.38 [0.17–0.87] for global cognitive decline; 0.44 [0.19–0.97] for memory function decline) and participants without cardiovascular disease (OR [95% CI]: 0.31 [0.11–0.87] for global cognitive decline; 0.34 [0.14–0.83] for memory function decline). The increases in other cholesterol were also negatively associated with the risk of cognitive decline although not significantly.Conclusions: A longitudinal increase in NHDL-C may be protective for cognition in females or individuals without cardiovascular disease.

scholarly journals Analysis of the Detection and Influencing Factors of Dyslipidemia in the Elderly in Wuwei： A Community-based Study

2020 ◽  
Author(s):  
Xiaochun Li ◽  
Junshan Yang ◽  
Zhaohua Ji
Keyword(s):  
Blood Glucose ◽  
High Density Lipoprotein ◽  
Influencing Factors ◽  
High Density Lipoprotein Cholesterol ◽  
Univariate Analysis ◽  
Density Lipoprotein ◽  
The Elderly ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Factors Affecting

Abstract Background: This study aimed to investigate the distribution of the incidence of dyslipidemia among the elderly in Wuwei, and explore the related factors affecting dyslipidemia. Methods: The physical examination data of 43,092 elder people aged 60 and over from 2012 to 2019 in Wuwei city were collected to analyze the incidence of dyslipidemia, and the factors affecting dyslipidemia were evaluated by univariate and multivariate analysis. Results: A total of 12,338 cases of dyslipidemia were reported in 43,092 patients, and the incidence of dyslipidemia was 28.6%. Among these dyslipidemia patients, the proportion of patients with low high-density lipoprotein cholesterol was the highest, and the proportion of patients with hypertriglyceridemia combined with low high-density lipoprotein cholesterol was the lowest. Univariate analysis showed that age, gender, smoking, alcohol consumption, blood glucose, blood pressure, weight, electrocardiogram, and total bilirubin were the influencing factors of dyslipidemia in the elderly, and the differences were statistically significant (P < 0.05). Multivariate logistic regression analysis indicated that female gender, overweight/obesity, abnormal blood glucose, and high alanine aminotransferase were independent risk factors for dyslipidemia in the elderly (P < 0.05). Conclusions: The age with the highest prevalence of dyslipidemia among the elderly in Wuwei city is 70–80 years old. Elderly women should strengthen the prevention and treatment of dyslipidemia. In order to avoid the occurrence of dyslipidemia, it is necessary to control body weight, blood glucose and improve liver function.

Nonlinear Relationship of Non-High-Density Lipoprotein Cholesterol and Cognitive Function in American Elders: A Cross-Sectional NHANES Study (2011–2014)

2022 ◽  
pp. 1-10
Author(s):  
Qiaoyang Zhang ◽  
Min Zhang ◽  
Yun Chen ◽  
Yin Cao ◽  
Guanzhong Dong
Keyword(s):  
Cognitive Function ◽  
High Density Lipoprotein ◽  
Dose Response ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Global Cognition

Background: Serum non-high-density lipoprotein-cholesterol (non-HDL-C) levels may be associated with cognitive function. Objective: The objective of this study was to evaluate the association between non-HDL-C and cognitive function among American elders. Methods: We used data from the 2011 to 2014 U.S. National Health and Nutrition Examination Survey (NHANES). A total of 3,001 participants aged over 60 years were enrolled in our analysis. The cognitive function was evaluated with the word learning subtest from the Consortium to Establish a Registry for Alzheimer’s disease (CERAD W-L), the Animal Fluency Test (AFT), and the digit symbol substitution test (DSST). We also created a composite cognitive z-score to represent a global cognition. We applied multivariate linear regression analyses to estimate the associations between non-HDL-C levels and all domains of cognitive function. Further, the generalized additive model and the smooth curve were conducted to investigate the dose-response relationship between non-HDL-C and global cognition. Results: Serum non-HDL-C was positively associated with global cognition (β= 0.20, 95% CI: 0.11, 0.28), AFT score (β= 0.54, 95% CI: 0.33, 0.76), and DSST score (β= 1.13, 95% CI: 0.56, 1.69) after fully adjusted. While non-HDL-C was not related to CERAD W-L score. In addition, an inverted U-shape curve was observed in the dose-response relationship between non-HDL-C and global cognition (p for non-linearity <  0.001). Conclusion: Serum non-HDL-C is positively and nonlinearly associated with cognitive function among American older adults. Maintaining serum cholesterol levels at an appropriate range may be helpful to the cognitive health of the elderly.

Obstructive sleep apnoea/hypopnea influences high-density lipoprotein cholesterol in the elderly

2009 ◽  
Vol 10 (8) ◽  
pp. 882-886 ◽  
Author(s):  
Frédéric Roche ◽  
Emilia Sforza ◽  
Vincent Pichot ◽  
Delphine Maudoux ◽  
Arnaultd Garcin ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Obstructive Sleep Apnoea ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
The Elderly ◽  
Sleep Apnoea ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Obstructive Sleep

Importance of high-density lipoprotein-cholesterol (HDL-C) levels to the incidence of cardiovascular disease (CVD) in the elderly

2011 ◽  
Vol 52 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Elizabete Viana de Freitas ◽  
Andréa Araújo Brandão ◽  
Roberto Pozzan ◽  
Maria Eliane Magalhães ◽  
Flávia Fonseca ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
The Elderly ◽  
High Density ◽  
Lipoprotein Cholesterol
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