Efficacy of Flumazenil in Acute Alcohol Intoxication: Double Blind Placebo-Controlled Evaluation

1991 ◽  
Vol 10 (4) ◽  
pp. 235-239 ◽  
Author(s):  
P. Lheureux ◽  
R. Askenasi
Keyword(s):  
Alcohol Intoxication ◽  
Controlled Trial ◽  
Acute Alcohol Intoxication ◽  
Double Blind ◽  
Evolution Of Consciousness ◽  
Pure Alcohol ◽  
Controlled Evaluation ◽  
Cns Depression ◽  
Higher Doses ◽  
Glasgow Score

Flumazenil acts as an antidote for pharmacological and toxic effects due to benzodiazepines. Several isolated observations and short uncontrolled series have also suggested a possible effect against the impairement of consciousness induced by pure alcohol intoxication. Patients admitted in the emergency department with coma related to acute alcohol (ALC) or pure benzodiazepine (BZD) intoxication were randomized and treated blindly with either placebo or 1 mg flumazenil. A modified Glasgow score was used to observe the evolution of consciousness. In the 18 ALC patients, 1 mg flumazenil was not more effective than placebo, whereas it appeared to be very active in the BZD group. However, an open administration of higher doses of flumazenil (2-5 mg) in 11 ALC patients, whose condition had not initially improved, was followed by clear improvement of consciousness in five of them. Flumazenil, administered at a dose usually active against BZD sedation, does not improve CNS depression induced by ALC intoxication. Higher doses could be more effective in some patients, but it should also be verified in a placebo-controlled trial.

Effect of Foeniculum vulgare (fennel) on vaginal atrophy in postmenopausal women: A double-blind, randomized, placebo-controlled trial

2017 ◽  
Vol 23 (4) ◽  
pp. 171-176 ◽  
Author(s):  
Masumeh Ghazanfarpour ◽  
Paymaneh Shokrollahi ◽  
Talat Khadivzadeh ◽  
Nosrat Baharian Sharghi ◽  
Khadijeh Mirzaii Najmabadi ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Controlled Trial ◽  
Vaginal Atrophy ◽  
Foeniculum Vulgare ◽  
Double Blind ◽  
Positive Effects ◽  
Higher Doses ◽  
Larger Sample ◽  
Paired T Test

Objectives This study was conducted to evaluate the effects of orally administered fennel on vaginal atrophy. Materials and methods In this double-blind, randomized, placebo-controlled trial, 60 postmenopausal women living in Mashhad, Iran, were randomly divided into an oral fennel group (n = 30) and a placebo group (n = 30). The Maturation Vaginal Index and maturation values were measured once at baseline and again upon a three-month follow-up. Results The paired t-test showed statistically significant changes in the Maturation Vaginal Index (i.e. a decline in the parabasal cells and an increase in the intermediate and superficial cells) and maturation values in both the fennel and placebo groups at the end of the trial compared to at baseline. Nonetheless, no significant differences were observed in the percentages of the parabasal (P = 0.191), intermediate (P = 0.219) and superficial (P = 0.82) cells, which was also the case for the maturation values (P = 0.64). Conclusion Fennel had no significant positive effects on vaginal atrophy in postmenopausal women. Nonetheless, more studies are recommended to be conducted using higher doses of fennel and larger sample sizes so as to verify the results of this study.

scholarly journals A double-blind randomized controlled trial of low doses of propranolol, nortriptyline, and the combination of propranolol and nortriptyline for the preventive treatment of migraine

2009 ◽  
Vol 67 (4) ◽  
pp. 973-977 ◽  
Author(s):  
Renan B. Domingues ◽  
André L. Pirajá da Silva ◽  
Simone A. Domingues ◽  
Camila Catherine H. Aquino ◽  
Gustavo W. Kuster
Keyword(s):  
Treatment Period ◽  
Adverse Reactions ◽  
Controlled Trial ◽  
Combined Therapy ◽  
Preventive Treatment ◽  
Double Blind ◽  
Randomized Controlled ◽  
Pre Treatment ◽  
Higher Doses

Few trials have evaluated combination of two or more drugs in the preventive treatment of migraine. In this study three therapeutic regimens were compared: (a) propranolol, at a dose of 40 mg per day, (b) nortriptyline, at a dose of 20 mg per day, and (c) the combination of these two drugs in these dosages. The groups were matched according to age, gender, and frequency of migraine attacks prior to treatment. The period of treatment was two months and the frequency and intensity of headache attacks of the 30 days pre-treatment period were compared with the frequency of headaches in the treatment period. Fourteen patients in groups A and B and sixteen patients in group C have completed the study. Treatment with propranolol, alone or in combination, was shown to be effective. Treatment with nortriptyline alone was not effective. All three therapeutic regimens were safe and side effects were minimal. The frequency of discontinuation of the study was the same in the 3 groups but no patient left the study due to adverse reactions. The combined therapy proved to be as safe as the monotherapy. Further studies evaluating this and other possible combinations of drugs in higher doses and for longer periods, should more clearly elucidate the role of combined therapy in the treatment of migraine.

Mesoridazine and Chlorpromazine in the Treatment of Alcohol Withdrawal Syndrome

1973 ◽  
Vol 18 (5) ◽  
pp. 385-387
Author(s):  
J.B. Frost
Keyword(s):  
Side Effects ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Alcohol Intoxication ◽  
Alcohol Withdrawal Syndrome ◽  
Acute Alcohol Intoxication ◽  
Double Blind ◽  
Therapeutic Regime ◽  
Significant Difference

Forty patients admitted for the treatment of alcohol withdrawal were placed on either chlorpromazine or mesoridazine on a double-blind basis. No significant difference in rate or degree of improvement between the two groups was noted and both groups showed an improvement which was more marked in the first week of treatment. There were few significant side effects from either drug. Improvement on either therapeutic regime is predictable and both are effective in relieving or lessening agitation, tremulousness, hallucinations and anxiety in patients recovering from acute alcohol intoxication.

13 P Metadoxine in acute alcohol intoxication: A double blind randomized placebo controlled study

2002 ◽  
Vol 34 ◽  
pp. A52
Author(s):  
G. Addolorato ◽  
R. Masciana ◽  
C. Ancona ◽  
G. De Lorenzi ◽  
F. Elia ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Controlled Study ◽  
Acute Alcohol Intoxication ◽  
Double Blind

Metadoxine in Acute Alcohol Intoxication: A Double-Blind, Randomized, Placebo-Controlled Study

2002 ◽  
Vol 26 (3) ◽  
pp. 340-346 ◽  
Author(s):  
Leonid S. Shpilenya ◽  
Alexander P. Muzychenko ◽  
Giovanni Gasbarrini ◽  
Giovanni Addolorato
Keyword(s):  
Alcohol Intoxication ◽  
Controlled Study ◽  
Acute Alcohol Intoxication ◽  
Double Blind

Double Blind Placebo Controlled Evaluation of Clinical Activity and Safety of Dation 500 mg in the Treatment of Acute Haemorrhoids

1994 ◽  
Vol 9 (1_suppl) ◽  
pp. 40-43 ◽  
Author(s):  
M. Cospite
Keyword(s):  
Controlled Trial ◽  
Signs And Symptoms ◽  
Clinical Severity ◽  
University Hospital ◽  
Clinical Activity ◽  
Patient Acceptability ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Haemorrhoidal Disease ◽  
Controlled Evaluation

Objective: Efficacy of treatment of acute haemorrhoidal crisis by Daflon 500 mg (D500) in comparison to a placebo (Pl). Design: Prospective, double blind, placebo controlled trial with randomization into two parallel groups. Setting: In- and outpatients at a University Hospital. Patients: One hundred patients with a history of haemorrhoidal disease, suffering from an acute haemorrhoidal attack. Interventions: Administration of Daflon 500 mg or placebo at a dose of three tablets b.i.d. for the first 4 days and two tablets b.i.d. for the following 3 days. Main outcome measures: Improvement of symptoms and signs measured by a score and patient acceptability. Results: Overall improvements of symptoms was greater in the D500 group than in the Pl group, from day 2 up to day 7. The clinical severity of proctorrhagia, anal discomfort, pain and anal discharge diminished in both groups, but to a greater extent in the D500 group ( p <0.001). Inflammation, congestion, oedema and prolapse were more markedly improved in the D500 group than in the Pl group. Duration and severity of the current haemorrhoidal episode, as assessed by patient self-evaluation, were less important in the D500 group compared with previous episodes. Use of analgesics and topical medications diminished in both groups, with a major reduction in the D500 group from day 4 ( p <0.001). Acceptability was good in both groups: no patient experienced major side-effects. Conclusion: Treatment with D500 resulted in a quicker and more pronounced relief of signs and symptoms of acute haemorrhoids than with the placebo.

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