RETRACTION NOTICE: Antibodies to cellular prion protein and its cognate ligand stress-inducible protein 1 in systemic lupus erythematosus

Objective.Serologically active clinically quiescent (SACQ) patients with systemic lupus erythematosus (SLE) remain clinically quiescent for prolonged periods despite anti-dsDNA antibodies and/or low complements, indicating the presence of immune complexes. The immune mechanisms leading to this quiescence are unknown. However, in addition to activating complement, immune complex uptake by various cells leads to the production of interferon (IFN)-α and other proinflammatory factors that are also involved in tissue damage. Here we investigate whether production of these factors is reduced in SACQ patients.Methods.The levels of 5 IFN-induced genes and 19 cyto/chemokines were measured in SACQ patients and were compared with those in serologically and clinically active (SACA) and serologically and clinically quiescent (SQCQ) patients. SACQ and SQCQ were defined as ≥ 2 years without clinical activity, with/without persistent serologic activity, respectively, and off corticosteroids/immunosuppressives. SACA was defined as disease activity compelling immunosuppression. Levels of OAS1, IFIT1, MX1, LY6E, and ISG15 were measured by quantitative real-time polymerase chain reaction (PCR) and a composite score (IFN-5) derived from this. Plasma cyto/chemokines were measured by Luminex assay. Nonparametric univariate and logistic regression analyses were conducted.Results.There were no differences in gene expression or cyto/chemokine levels between SACQ and SQCQ patients. The SACQ IFN-5 score was significantly lower than that of SACA (p = 0.003) and was driven by SACQ status, not by autoantibody profile or disease duration. Levels of granulocyte-macrophage colony-stimulating factor, interleukin (IL) 6, IL-10, IFN-γ-inducible protein 10, monocyte chemoattractant protein 1, and tumor necrosis factor-α were significantly lower in SACQ than SACA.Conclusion.The levels of proinflammatory factors in SACQ mirror those of SQCQ patients, indicating reduced production of these factors despite the presence of immune complexes.

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Interferon-γ–inducible protein p16. a new target of antinuclear antibodies in patients with systemic lupus erythematosus

Arthritis & Rheumatism ◽

10.1002/art.1780371117 ◽

1994 ◽

Vol 37 (11) ◽

pp. 1672-1683 ◽

Cited By ~ 37

Author(s):

Hans Peter Seelig ◽

Hans Ehrfeld ◽

Manfred Renz

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antinuclear Antibodies ◽

Interferon Γ ◽

Systemic Lupus ◽

Inducible Protein

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SERUM LEVELS OF IFN-INDUCIBLE PROTEIN-10 RELATING TO THE ACTIVITY OF SYSTEMIC LUPUS ERYTHEMATOSUS

Cytokine ◽

10.1006/cyto.2000.0757 ◽

2000 ◽

Vol 12 (10) ◽

pp. 1561-1565 ◽

Cited By ~ 83

Author(s):

Shosaku Narumi ◽

Tsutomu Takeuchi ◽

Yuko Kobayashi ◽

Konosuke Konishi

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Serum Levels ◽

Systemic Lupus ◽

Inducible Protein

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Interferon-Inducible Protein 10 and Disease Activity in Systemic Lupus Erythematosus and Lupus Nephritis: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences ◽

10.3390/ijms20194954 ◽

2019 ◽

Vol 20 (19) ◽

pp. 4954 ◽

Cited By ~ 3

Author(s):

Pongpratch Puapatanakul ◽

Sonchai Chansritrakul ◽

Paweena Susantitaphong ◽

Thornthun Ueaphongsukkit ◽

Somchai Eiam-Ong ◽

...

Keyword(s):

Systematic Review ◽

Systemic Lupus Erythematosus ◽

Lupus Nephritis ◽

Disease Activity ◽

Lupus Erythematosus ◽

Meta Analysis ◽

Systemic Disease ◽

Systemic Lupus ◽

Inducible Protein ◽

Interferon Inducible Protein

There is increasing evidence of a correlation between interferon-inducible protein 10 (IP-10) and disease activity of systemic lupus erythematosus (SLE) and lupus nephritis (LN). We conducted a comprehensive search on IP-10 using MEDLINE, Scopus, and Cochrane electronic databases from the beginning to the end of December 2017. All studies that compared serum and/or urine IP-10 between active SLE/LN patients and any control groups were identified and included in this systematic review and meta-analysis. The mean difference (MD) of IP-10 level among active SLE and LN patients, as well as the correlation of IP-10 with disease activity, were meta-analyzed using a random-effects model. From 23 eligible studies, 15 provided adequate data for meta-analysis. Serum IP-10 was significantly elevated in patients with active SLE compared to non-active SLE patients (MD 356.5 pg/mL, 95% CI 59.6 to 653.4, p = 0.019). On the other hand, the levels of serum IP-10 was not different between active LN and non-active LN. However, serum IP-10 was positively correlated with disease activity like SLE disease activity index (SLEDAI) (pooled r = 0.29, 95% CI 0.22 to 0.35, p < 0.001). Furthermore, urine IP-10 tended to be higher in patients with active LN compared to non-active LN patients but this did not reach statistical significance (MD 3.47 pg/mgCr × 100, 95% CI −0.18 to 7.12, p = 0.06). Nevertheless, urine IP-10 was positively correlated with renal SLEDAI (pooled r = 0.29, 95% CI 0.05 to 0.50, p = 0.019). In conclusion, serum and urine IP-10 levels may be useful in monitoring the disease activity of SLE and LN. Serum IP-10 was correlated with systemic disease whereas urine IP-10 was a useful biomarker for detecting active LN.

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Vitamin D receptor is negatively correlated with interferon-γ-inducible protein-10 in systemic lupus erythematosus with renal involvement

European Journal of Inflammation ◽

10.1177/2058739220942333 ◽

2020 ◽

Vol 18 ◽

pp. 205873922094233

Author(s):

Xueqin Wu ◽

Hao Zhang ◽

Shuang Zhang ◽

Jinzhong Yuan ◽

Jishi Liu ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Vitamin D Receptor ◽

Lupus Erythematosus ◽

Mononuclear Cells ◽

Renal Involvement ◽

Mrna Levels ◽

Systemic Lupus ◽

Peripheral Blood Mononuclear ◽

Inducible Protein

The vitamin D receptor (VDR) plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) mainly due to its anti-inflammatory and immunomodulatory activities. Interferon-inducible protein-10 (IP-10) is a chemokine found to be increased in SLE patients and correlated with severity of lupus nephritis. In this case control study, we investigated the connection between VDR expression and chemokine IP-10 in peripheral blood mononuclear cells (PBMCs) of SLE patients with or without renal involvement. 62 SLE patients and 30 healthy subjects were enrolled between 2014 and 2016. PBMC VDR mRNA and IP-10 mRNA were quantified by real-time PCR. PBMC VDR protein was measured by Western blotting. PBMC VDR mRNA and protein were downregulated, whereas IP-10 mRNA was upregulated in SLE patients with renal involvement. VDR mRNA levels were negatively correlated with systemic lupus international collaborating clinics (SLICC) renal activity scores (r = −0.423, P = 0.016) and IP-10 mRNA levels (r = −0.428, P = 0.008) in SLE with renal involvement. This study demonstrates that PBMC VDR was negatively correlated with SLICC renal activity and chemokine IP-10 in SLE patients with renal involvement which suggests that VDR downregulation may be used as an indicator of renal injury in SLE patients.

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