Erratum to remission and long-term outcomes of proliferative lupus nephritis: Retrospective study of 96 patients from Saudi Arabia

Background Few data are available about the rate of short-term remission and its impact on the long-term outcomes of proliferative lupus nephritis in the Middle East. Methods An observational study was carried out involving 96 adult patients with biopsy-proven focal or diffuse proliferative lupus nephritis (PLN) from four different hospitals. Data on induction, remission and long-term outcomes were collected and analyzed. Results Among the 96 patients with biopsy-proven PLN (median age 27 (IQR: 21,34) years, 85% women and median duration of systemic lupus erythematosus (SLE) prior to diagnosis 27 (IQR: 11, 55) months), 67% developed remission at 6 months (proportion 0.67; 95% CI 0.57, 0.76). Mycophenolate mofetil (MMF) was used in 45/96 (47%), CYC in 41/95 (43%) and other agents in 10/96 (10%). The choice of MMF as induction agent has increased in recent years. Among baseline characteristics, only histologic activity was found to have a significant association with remission, with active lesions more likely to remit than active/chronic and chronic lesions (AOR 6.5, 95% CI 1.44–29.39, p = 0.015). Based on Kaplan–Meier analysis, the 5-year renal survival rate without doubling serum creatinine was 73.8%. Compared to patients with complete remission, lower long-term renal survival rates were observed in patients with no remission (89.7 versus 43%, p = 0.001) and partial remission (89.7 versus 77.6%, p = 0.256). The cumulative rate of doubling serum creatinine, dialysis, relapse and death was 23%, 11%, 10% and 5%, respectively, at 48-month median follow up. Conclusion Approximately two-thirds of patients with PLN develop remission in response to standard induction therapy. Remission was negatively associated with the presence of chronic changes in renal biopsy. Overall, MMF is the most commonly used agent to induce remission; however, with more severe disease CYC, is used more frequently. PLN is associated with significant long-term renal outcomes including a 26% cumulative rate of doubling of serum creatinine at 5 years. Initial remission predicts this long-term renal survival.

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ID: 3523886 LONG-TERM OUTCOMES AND SURVIVAL AFTER ENDOSCOPIC OR SURGICAL RESECTION FOR T1 COLORECTAL CANCER: A MULTICENTER RETROSPECTIVE STUDY

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2021.03.224 ◽

2021 ◽

Vol 93 (6) ◽

pp. AB86

Author(s):

Hirohito Tanaka ◽

Shiko Kuribayashi ◽

Masanori Sekiguchi ◽

Atsuo Iwamoto ◽

Yoko Hachisu ◽

...

Keyword(s):

Colorectal Cancer ◽

Retrospective Study ◽

Surgical Resection ◽

Long Term Outcomes ◽

T1 Colorectal Cancer

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Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-206897 ◽

2015 ◽

Vol 75 (3) ◽

pp. 526-531 ◽

Cited By ~ 68

Author(s):

Farah Tamirou ◽

David D'Cruz ◽

Shirish Sangle ◽

Philippe Remy ◽

Carlos Vasconcelos ◽

...

Keyword(s):

Mycophenolate Mofetil ◽

Lupus Nephritis ◽

Positive Predictive Value ◽

Maintenance Therapy ◽

Early Response ◽

Renal Outcome ◽

Proliferative Lupus Nephritis ◽

Long Term Follow Up

ObjectiveTo report the 10-year follow-up of the MAINTAIN Nephritis Trial comparing azathioprine (AZA) and mycophenolate mofetil (MMF) as maintenance therapy of proliferative lupus nephritis, and to test different definitions of early response as predictors of long-term renal outcome.MethodsIn 2014, data on survival, kidney function, 24 h proteinuria, renal flares and other outcomes were collected for the 105 patients randomised between 2002 and 2006, except in 13 lost to follow-up.ResultsDeath (2 and 3 in the AZA and MMF groups, respectively) and end-stage renal disease (1 and 3, respectively) were rare events. Time to renal flare (22 and 19 flares in AZA and MMF groups, respectively) did not differ between AZA and MMF patients. Patients with good long-term renal outcome had a much more stringent early decrease of 24 h proteinuria compared with patients with poor outcome. The positive predictive value of a 24 h proteinuria <0.5 g/day at 3 months, 6 months and 12 months for a good long-term renal outcome was excellent (between 89% and 92%). Inclusion of renal function and urinalysis in the early response criteria did not impact the value of early proteinuria decrease as long-term prognostic marker.ConclusionsThe long-term follow-up data of the MAINTAIN Nephritis Trial do not indicate that MMF is superior to AZA as maintenance therapy in a Caucasian population suffering from proliferative lupus nephritis. Moreover, we confirm the excellent positive predictive value of an early proteinuria decrease for long-term renal outcome.Trial registration numberNCT00204022.

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Long-term outcomes in antineutrophil cytoplasmic autoantibody–positive eosinophilic granulomatosis with polyangiitis patients with renal involvement: a retrospective study of 14 Chinese patients

BMC Nephrology ◽

10.1186/s12882-016-0319-2 ◽

2016 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Yinghua Chen ◽

Yuemei Ding ◽

Zhengzhao Liu ◽

Haitao Zhang ◽

Zhihong Liu ◽

...

Keyword(s):

Retrospective Study ◽

Granulomatosis With Polyangiitis ◽

Renal Involvement ◽

Chinese Patients ◽

Eosinophilic Granulomatosis With Polyangiitis ◽

Long Term Outcomes ◽

Antineutrophil Cytoplasmic Autoantibody ◽

Eosinophilic Granulomatosis

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Short- and Long-Term Outcomes of Living Donors in Tunisia: A Retrospective Study

Transplantation Proceedings ◽

10.1016/j.transproceed.2010.09.119 ◽

2010 ◽

Vol 42 (10) ◽

pp. 4311-4313 ◽

Cited By ~ 2

Author(s):

M. Cherif ◽

M. Ounissi ◽

C. Karoui ◽

K. Boubaker ◽

I. Helal ◽

...

Keyword(s):

Retrospective Study ◽

Living Donors ◽

Long Term Outcomes ◽

Short And Long Term

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Short- and long-term outcomes after valve replacement surgery for rheumatic heart disease in the South Pacific, conducted by a fly-in/fly-out humanitarian surgical team: A 20-year retrospective study for the years 1991 to 2011

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2014.02.006 ◽

2014 ◽

Vol 148 (5) ◽

pp. 1996-2003 ◽

Cited By ~ 11

Author(s):

Linda Thomson Mangnall ◽

David Sibbritt ◽

Margaret Fry ◽

Robyn Gallagher

Keyword(s):

Heart Disease ◽

Retrospective Study ◽

Rheumatic Heart Disease ◽

Surgical Team ◽

Long Term Outcomes ◽

Replacement Surgery ◽

Short And Long Term ◽

Valve Replacement Surgery ◽

Rheumatic Heart

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Long-Term Outcomes and Factors Related to the Prognosis of Pure Ovarian Dysgerminoma: A Retrospective Study of 107 Cases

Gynecologic and Obstetric Investigation ◽

10.1159/000519515 ◽

2021 ◽

pp. 1-8

Author(s):

Tianyun Xu ◽

Fei Sun ◽

Yanfang Li

Keyword(s):

Retrospective Study ◽

Survival Rate ◽

Disease Free Survival ◽

Small Sample ◽

Stage I ◽

Long Term Outcomes ◽

Free Survival ◽

Disease Free Survival Rate ◽

Disease Free

Objective: The aim of this study was to evaluate the long-term outcomes and the factors related to patient prognosis. Materials and Methods: We retrospectively analyzed patients treated at the Department of Gynecology, Sun Yat-sen University Cancer Center, between January 1, 1968, and December 12, 2018. Results: A total of 107 patients were identified. Of all patients, 79 (73.8%) presented with stage I disease, 14 (13.1%) stage II, 13 (12.2%) stage III, and 1 (0.9%) stage IV. All patients received surgery, with 70 (65.4%) undergoing fertility-sparing surgery (FS) and 37 (34.6%) nonfertility-sparing surgery (NFS). Ninety patients received postoperative chemotherapy. Nine of the 43 cases with a lymphadenectomy had metastasis (20.9%). The median follow-up time was 132 months (range, 1–536 months). The overall 5-year and 10-year survival was 95.1% and 91.7%, respectively. The 10-year survival rate for stage I and II–IV patients was 96.1% and 79.1%, respectively (p = 0.008). For the patients undergoing FS and NFS, the 10-year disease-free survival rate was 82.3% and 88.0%, respectively (p = 0.403). The 10-year disease-free survival rate for patients with or without lymphadenectomy was 95.1% and 78.4%, respectively (p = 0.040), and it was 92.5% and 76.0%, respectively (p = 0.041), for those with or without omentectomy. Fifteen patients relapsed, and 4 of them (26.7%) had recurrence in the lymph nodes. Eleven of the 15 relapsed patients (73.3%) had been successfully salvaged. Limitations: As a study of a rare disease, our analysis was limited by its small sample size and the deemed disadvantage of a retrospective study. Conclusion: Excellent treatment results can be achieved in dysgerminoma patients who received proper treatment. Lymphadenectomy may improve patient survival. Relapsed patients can also be successfully salvaged.

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