Partial dopamine agonist-induced pathological gambling and impulse-control deficit on low-dose aripiprazole

Objective: To describe a case of aripiprazole-induced problem gambling and impulse-control deficit in a gambling-naïve patient following commencement of low-dose aripiprazole. Method: Case report. Results: This case adds to the literature on the dopamine partial agonist aripiprazole causing or exacerbating problem gambling, and extends that literature to low-dose use of aripiprazole in the gambling naïve. Conclusions: When commencing a patient on aripiprazole the possibility of emergence of problem gambling and other impulse-control deficits should be monitored, even in those with no history of similar behaviours and even on a low dose

Download Full-text

Before and after nalmefene, a case report

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.1079 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S316-S316

Author(s):

N. Salgado ◽

S. Benavente ◽

B. Macías ◽

C. Sanchez

Keyword(s):

Case Report ◽

Alcohol Consumption ◽

Partial Agonist ◽

Heavy Drinking ◽

Serological Examination ◽

Improve Liver Function ◽

Before And After ◽

Clinical Diagnoses ◽

History Of ◽

Competing Interest

IntroductionClinical and social improvement after treatment with nalmefene in an alcoholic 41-year-old male, with history of dependence during 20 years.Case reportOur patient had been abusing alcohol for almost 20 years with short breaks of abstinence (one month). Before treatment he made a consumption of 105 g of alcohol per day. Serological examination showed hepatic alterations (GGT 2115, ALT 229) and a low amount of platelets (61,000). He also had no other relevant medical history and other possible clinical diagnoses were excluded. After a week detoxification program and alcohol consumption cessation during one month, the analytical values drastically changed: ALT 35, GGT 275, platelets 222,000.DiscussionNalmefene is an opioid system modulator with antagonist activity at the μ and δ receptors and partial agonist activity at the κ receptor. Nalmefene as-needed has been shown to reduce the total amount of alcohol consumption and number of heavy drinking days and to improve liver function. The aim of this treatment is centered in decreasing consumption rather than achieving a total abstinence.ConclusionsAgainst other pharmacologic approaches such as disulfiram an acamprosate, the options that allow acute consumption help patients in controlling drinking rampage and make them realize they will be able to afford alcohol cessation.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Download Full-text

Tricyclic Medication in Children and the QT Interval: Case Report and Discussion

The Canadian Journal of Psychiatry ◽

10.1177/070674379504000608 ◽

1995 ◽

Vol 40 (6) ◽

pp. 325-329 ◽

Cited By ~ 14

Author(s):

R. Alderton Harvey

Keyword(s):

Case Report ◽

Children And Adolescents ◽

Qt Interval ◽

Low Dose ◽

Close Monitoring ◽

Dose Increase ◽

Ecg Changes ◽

Cardiac Disorder ◽

History Of ◽

Qt Syndrome

Objective To identify the necessity for close monitoring of the QT interval in children and adolescents treated with tricyclics. Method Guidelines for permissible ECG changes are reviewed and a case report of a 12-year-old girl with idiopathic long QT syndrome, no history of cardiac disorder, a questionable family history, and normal physical examination and baseline ECG is presented. Results Marked increase in QT corrected for heart rate (QTc) occurred on low-dose tricyclic. Possible factors in deaths on desipramine are reviewed. Conclusion It is recommended that children and adolescents on tricyclics receive an ECG at baseline and after each dose increase. Recommendations are made regarding ECG parameters and indications for cardiac consultation.

Download Full-text

DU127090: A novel partial dopamine agonist with antipsychotic activity partial agonist character in functional assays in vivo

Schizophrenia Research ◽

10.1016/s0920-9964(03)80875-7 ◽

2003 ◽

Vol 60 (1) ◽

pp. 117 ◽

Cited By ~ 1

Author(s):

A. van Kolfschoten ◽

M.B. Hesselink ◽

S.K. Long ◽

R.W. Feenstra ◽

J. Arnt ◽

...

Keyword(s):

Dopamine Agonist ◽

Partial Agonist ◽

Functional Assays ◽

Antipsychotic Activity ◽

Partial Dopamine Agonist

Download Full-text

Impulse control dysfunction and dopamine agonist withdrawal syndrome in Genetic Parkinson’s: A case report

Basal Ganglia ◽

10.1016/j.baga.2015.05.003 ◽

2015 ◽

Vol 5 (2-3) ◽

pp. 57-58 ◽

Cited By ~ 3

Author(s):

Antoniya Todorova ◽

Christina Bitsara ◽

Ericka Samantha A. Teleg ◽

Kallol Ray Chaudhuri

Keyword(s):

Case Report ◽

Dopamine Agonist ◽

Withdrawal Syndrome ◽

Impulse Control

Download Full-text

Psychosis and concurrent impulse control disorder in Parkinson's disease: A review based on a case report

Dementia & Neuropsychologia ◽

10.1590/s1980-5764-2016dn1002011 ◽

2016 ◽

Vol 10 (2) ◽

pp. 148-151

Author(s):

Bruno Fukelmann Guedes ◽

Marcia Rubia Gonçalves ◽

Rubens Gisbert Cury

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Case Report ◽

Pathological Gambling ◽

Replacement Therapy ◽

Impulse Control ◽

Psychiatric Symptoms ◽

Repetitive Behaviors ◽

Dopamine Replacement Therapy ◽

Psychiatric Complications

ABSTRACT Psychosis, impulse control disorders (e.g., pathological gambling and hypersexuality) and repetitive behaviors such as punding are known psychiatric complications of Parkinson's disease (PD). Impulsive, compulsive and repetitive behaviors are strongly associated with dopamine-replacement therapy. We present the case of a 58-year-old man with PD and a myriad of psychiatric symptoms. Concurrent psychosis, punding and pathological gambling developed more than six years after the introduction of pramipexole and ceased shortly after the addition of quetiapine and discontinuation of pramipexole. This report emphasizes the importance of monitoring for a wide array of psychiatric symptoms in patients on dopamine replacement therapy.

Download Full-text

Impulse Control Disorder in a Patient with Invasive Prolactinoma on Dopamine agonist Therapy: A Case Report

Endocrinology and Disorders ◽

10.31579/2640-1045/038 ◽

2019 ◽

Vol 3 (1) ◽

pp. 01-03

Author(s):

Pinaki Dutt

Keyword(s):

Case Report ◽

Adverse Events ◽

Dopamine Agonist ◽

Pituitary Adenomas ◽

Impulse Control ◽

Agonist Therapy ◽

Debulking Surgery ◽

Dopamine Agonist Therapy ◽

Invasive Prolactinoma

Prolactinomas constitutes a major bulk of pituitary adenomas. All symptomatic prolactinomas require dopamine agonist (DA) therapy. Impulse control disorders (ICD) or pathological behaviours are rare adverse events described with use of DA. Herein we are describing a male patient with pathological gambling and doctor shopping following use of bromocriptine and higher dose of cabergoline.The pathological behaviour disappeard after debulking surgery, reduction in cabergoline dose and several sessions of counselling. Physicians prescribing DA should be aware of this potential adverse event.This should be emphasized to the patient and family members before starting DA and physician should be inquisitive for eliciting pathological behaviour on follow up.

Download Full-text

Risperidone induced tardive dyskinesia

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20210191 ◽

2021 ◽

Vol 10 (2) ◽

pp. 196

Author(s):

Elakkya Kolanchinathan ◽

Dhanya Thirookaran Harichandran ◽

Sujatha Mangattuvalappil Balakrishnan

Keyword(s):

Case Report ◽

Tardive Dyskinesia ◽

Atypical Antipsychotic ◽

Antipsychotic Drug ◽

Male Patient ◽

Low Dose ◽

Paranoid Schizophrenia ◽

Extrapyramidal Symptoms ◽

Atypical Antipsychotic Drug ◽

History Of

Risperidone is an atypical antipsychotic drug which has been less likely to produce extrapyramidal symptoms. The aim of this case report is to illustrate that low dose risperidone may cause tardive dyskinesia. A 29 year old male patient with 9 year history of paranoid schizophrenia, developed tardive dyskinesia after receiving risperidone 2 mg for 7 years. He had received small dosages of Haloperidol before the therapy of risperidone for short periods.

Download Full-text

Popliteal artery thrombosis secondary to a tibial osteochondroma

VASA ◽

10.1024/0301-1526/a000101 ◽

2011 ◽

Vol 40 (3) ◽

pp. 251-255 ◽

Cited By ~ 4

Author(s):

Gruber-Szydlo ◽

Poreba ◽

Belowska-Bien ◽

Derkacz ◽

Badowski ◽

...

Keyword(s):

Case Report ◽

Magnetic Resonance Angiography ◽

Popliteal Artery ◽

Doppler Ultrasonography ◽

Histopathological Examination ◽

Previous History ◽

Plain Radiography ◽

Artery Thrombosis ◽

History Of ◽

The Right

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

Download Full-text