scholarly journals Diagnosis of Preclinical and Subclinical Scrapie in a Naturally Infected Sheep Flock Utilizing Currently Available Postmortem Diagnostic Techniques

2001 ◽  
Vol 13 (2) ◽  
pp. 152-154 ◽  
Author(s):  
Amir N. Hamir ◽  
Janice M. Miller ◽  
Mary Jo Schmerr ◽  
Mick J. Stack ◽  
Melanie J. Chaplin ◽  
...  
2019 ◽  
Vol 43 (2) ◽  
pp. 264-270
Author(s):  
Jana AVBERŠEK ◽  
Mateja PATE ◽  
Andrej ŠKIBIN ◽  
Matjaž OCEPEK ◽  
Brane KRT
Keyword(s):  
Q Fever ◽  

2010 ◽  
Vol 107 (5) ◽  
pp. 1205-1211 ◽  
Author(s):  
Maria Martínez-Valladares ◽  
Maria del Rosario Famularo ◽  
Nelida Fernández-Pato ◽  
Luciano Castañón-Ordóñez ◽  
Coral Cordero-Pérez ◽  
...  

2016 ◽  
Vol 7 (2) ◽  
pp. 384-389 ◽  
Author(s):  
Vladimir López ◽  
Pilar Alberdi ◽  
Isabel G. Fernández de Mera ◽  
José Angel Barasona ◽  
Joaquín Vicente ◽  
...  

2010 ◽  
Vol 42 (7) ◽  
pp. 1327-1331 ◽  
Author(s):  
Alessandra Torina ◽  
Ruth C. Galindo ◽  
Joaquín Vicente ◽  
Vincenzo Di Marco ◽  
Miriam Russo ◽  
...  

2013 ◽  
Vol 9 (1) ◽  
pp. 16 ◽  
Author(s):  
Margrét Gudnadóttir ◽  
Andreas Demosthenous ◽  
Theophanis Hadjisavvas
Keyword(s):  

1999 ◽  
Vol 354 (1384) ◽  
pp. 751-756 ◽  
Author(s):  
M. E. J. Woolhouse ◽  
L. Matthews ◽  
P. Coen ◽  
S. M. Stringer ◽  
J. D. Foster ◽  
...  

A detailed analysis of an outbreak of natural scrapie in a flock of Cheviot sheep is described. A total of 137 cases was reported over 13 years among 1307 sheep born into the flock. The epidemiology of scrapie can only be understood with reference to sheep demography, the population genetics of susceptibility to scrapie, pathogenesis during a long incubation period, and the rate of transmission (by both vertical and horizontal routes), all of which interact in complex ways. A mathematical model incorporating these features is described, parameter values and model inputs are derived from available information from the flock and from independent sources, and model outputs are compared with the field data. The model is able to reproduce key features of the outbreak, including its long duration and the ages of cases. The analysis supports earlier work suggesting that many infected sheep do not survive to show clinical signs, that most cases arise through horizontal tranmission, and that there is strong selection against susceptible genotypes. However, important aspects of scrapie epidemiology remain poorly understood, including the possible role of carrier genotypes and of an environmental reservoir of infectivity, and the mechanisms maintaining alleles giving susceptibility to scrapie in the sheep population.


2013 ◽  
Vol 196 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Ianire Astobiza ◽  
Jesús F. Barandika ◽  
Ramón A. Juste ◽  
Ana Hurtado ◽  
Ana L. García-Pérez
Keyword(s):  
Q Fever ◽  

2008 ◽  
Vol 46 (5) ◽  
pp. 1686-1691 ◽  
Author(s):  
G. A. F. Ladbury ◽  
S. Stuen ◽  
R. Thomas ◽  
K. J. Bown ◽  
Z. Woldehiwet ◽  
...  

2008 ◽  
Vol 13 (2) ◽  
pp. 6-8
Author(s):  
Lorne Direnfeld ◽  
Christopher R. Brigham ◽  
Elizabeth Genovese

Abstract The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), does not provide a Diagnosis-based estimate of impairment due to syringomyelia, a disorder in which a cyst (syrinx), develops within the central spinal cord and destroys neural tissue as it expands. The AMA Guides, however, does provide an approach to rating a syringomyelia based on objective findings of neurological deficits identified during a neurological examination and demonstrated by standard diagnostic techniques. Syringomelia may occur after spinal cord trauma, including a contusion of the cord. A case study illustrates the rating process: The case patient is a 46-year-old male who fell backwards, landing on his upper back and head; over a five-year period he received a T5-6 laminectomy and later partial corpectomies of C5, C6, and C7, cervical discectomy C5-6 and C6-7; iliac crest strut graft fusion of C5-6 and C6-7; and anterior cervical plating of C5 to C7 for treatment of myelopathy; postoperatively, the patient developed dysphagia. The evaluating physician should determine which conditions are ratable, rate each of these components, and combine the resulting whole person impairments without omission or duplication of a ratable impairment. The article includes a pain disability questionnaire that can be used in conjunction with evaluations conducted according to Chapter 3, Pain, and Chapter 17, The Spine.


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