Tocainide: A Severe Adverse Reaction

1988 ◽  
Vol 22 (2) ◽  
pp. 142-145 ◽  
Author(s):  
James M. Dunn ◽  
Paul E. Groth ◽  
Anne DeSimone
Keyword(s):  
Adverse Reaction ◽  
Short Term Memory ◽  
Memory Loss ◽  
Uneventful Recovery ◽  
Physical Status ◽  
Short Term ◽  
Severe Adverse Reaction ◽  
Premature Ventricular Contractions ◽  
Term Memory ◽  
Cardioactive Drug

Tocainide is a primary analog of lidocaine with antiarrhythmic properties used to treat ventricular rhythm disorders. A 76-year-old man with benign paroxysmal premature ventricular contractions was treated with tocainide and developed a generalized maculopapular lupoid eruption, bleeding from the lips and gingivae, vertigo, gross tremors of the extremities, fever, and short-term memory loss, which required hospitalization. The patient recovered slowly over three months with no permanent sequelae after discontinuing the drug and receiving rigorous supportive care. His excellent physical status and absence of concomitant illness contributed to an uneventful recovery. Tocainide is a potent cardioactive drug with a long biological half-life and should be used with caution.

Short-Term Memory Loss Associated with Rosuvastatin

2006 ◽  
Vol 26 (8) ◽  
pp. 1190-1192 ◽  
Author(s):  
Laura Galatti ◽  
Giovanni Polimeni ◽  
Francesco Salvo ◽  
Marcello Romani ◽  
Aurelio Sessa ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Memory Loss ◽  
Short Term ◽  
Term Memory

scholarly journals High methionine, low folate and low vitamin B6/B12 (HM-LF-LV) diet causes neurodegeneration and subsequent short-term memory loss

2018 ◽  
Vol 33 (6) ◽  
pp. 1923-1934 ◽  
Author(s):  
Mohammed Nuru ◽  
Nino Muradashvili ◽  
Anuradha Kalani ◽  
David Lominadze ◽  
Neetu Tyagi
Keyword(s):  
Vitamin B6 ◽  
Short Term Memory ◽  
Memory Loss ◽  
Short Term ◽  
Term Memory

104. Do patients with end-stage renal failure and short-term memory loss have Alzheimerʼs disease

1997 ◽  
Vol 18 (4) ◽  
pp. 320
Author(s):  
P. Lass ◽  
J. R. Buscombe ◽  
A. Davenport ◽  
S. Gacinovic ◽  
D. S. Thakrar ◽  
...  
Keyword(s):  
Renal Failure ◽  
Short Term Memory ◽  
Memory Loss ◽  
Short Term ◽  
Term Memory ◽  
End Stage Renal Failure ◽  
End Stage

Effects of Short-Term Memory on Electrical Behaviors of Postextrasystolic Beats

2013 ◽  
Vol 647 ◽  
pp. 245-249
Author(s):  
Hong Zhang ◽  
Juan Wang ◽  
Lin Yang ◽  
Yong Bo Liu
Keyword(s):  
Personal Computer ◽  
Short Term Memory ◽  
Intrinsic Property ◽  
Short Term ◽  
Premature Ventricular Contractions ◽  
Term Memory ◽  
One Dimensional ◽  
Long Time ◽  
Unidirectional Block ◽  
Reentrant Arrhythmias

Cardiac short-term memory which reflects the influence of pacing history is an intrinsic property of paced myocardium. It has been observed that premature ventricular contractions (PVCs) facilitate initiation of reentrant tachyarrhythmias. However, little is known about effects of pacing history on electrical behaviors of postextrasystolic beats. In the paper, by incorporating endo-, mid-, and epi-cardial myocytes, we developed a one-dimensional heterogeneous fiber to examine effects of the number of regular stimulations before PVCs on postextrasystolic depolarizations (PEDs). OpenMP parallel algorithm was performed on a four-core personal computer to accelerate the calculation. The results showed that for any type of myocytes, APDs for PEDs became longer for 500 than for 100 regular driven beats. The calculated ECGs reflected that repolarisation of the tissue was also lengthened for the fast long time pacing. Therefore, it was suggested that because of accumulation of memory, prolonged APDs and repolarisation after PVCs could provide sites for unidirectional block in the tissue and increase the risk of reentrant arrhythmias.

Drug inhibition of memory formation in chickens II. Short-term memory

1971 ◽  
Vol 178 (1053) ◽  
pp. 455-464 ◽  
Keyword(s):  
Protein Synthesis ◽  
Sodium Pump ◽  
Short Term Memory ◽  
Memory Loss ◽  
Protein Synthesis Inhibitor ◽  
Protein Synthesis Inhibitors ◽  
Short Term ◽  
Synthesis Inhibitor ◽  
Term Memory

1. Memory in day-old-chickens during the first few hours after learning can be made to decline by the prior intracranial injection of two classes of drugs. 2. Sodium pump inhibitors in increasing doses cause increasingly rapid loss of memory. 3. Protein synthesis inhibitors in increasing doses attain a maximum potency in causing memory decline and the rate may not be further accelerated by higher doses. 4. Adding a sodium pump inhibitor to the inhibition of protein synthesis increases memory loss. 5. Adding a protein synthesis inhibitor to a sodium pump inhibitor causes no further loss. 6. Therefore within a few minutes of learning a short-term memory of limited time span but independent of protein synthesis becomes supplemented and eventually replaced by a long-term storage requiring protein synthesis. The amount of long-term store is set by the amount of short-term memory. 7. The short-term store could be directly dependent on post-activation enhancement of Na + extrusion from neurons. Some physiological mechanisms by which this could be achieved and how this might activate protein synthesis are discussed.

LGI1 antibody encephalitis and psychosis

2018 ◽  
Vol 26 (6) ◽  
pp. 612-614 ◽  
Author(s):  
Dahai Wang ◽  
Qinjian Hao ◽  
Lan He ◽  
Qiang Wang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Short Term Memory ◽  
Background Activity ◽  
Early Recognition ◽  
Memory Loss ◽  
Psychotic Symptoms ◽  
Resonance Imaging ◽  
Short Term ◽  
Term Memory ◽  
Hippocampal Lesions

Objective: To describe a case of leucine-rich, glioma inactivated 1 antibody-encephalitis presenting with psychosis. Methods: Case report. Results: A young man with leucine-rich, glioma inactivated 1-antibody encephalitis initially presented with acute psychotic symptoms, short-term memory loss and faciobrachial dystonic seizures. Magnetic resonance imaging revealed hippocampal lesions. Electroencephalography revealed frontotemporal slowing of background activity. Conclusion: Increased awareness of leucine-rich, glioma inactivated 1-antibody encephalitis may promote early recognition and treatment.

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