Inappropriate Use of D-Dimer Assay and Pulmonary CT Angiography in the Evaluation of Suspected Acute Pulmonary Embolism

2011 ◽  
Vol 27 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Fang Yin ◽  
Thomas Wilson ◽  
Albert Della Fave ◽  
Moira Larsen ◽  
Jenni Yoon ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
Inappropriate Use ◽  
D Dimer ◽  
Pulmonary Ct

scholarly journals D-dimer levels and acute pulmonary embolism development in COVID-19 patients

2021 ◽  
Vol 8 (1) ◽  
pp. 133-138
Author(s):  
Vural Ahmet ◽  
Kahraman Nedim
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
Community Hospital ◽  
Demographic Parameters ◽  
Ct Angiogram ◽  
Thorax Ct ◽  
D Dimer ◽  
Pulmonary Ct

Objective. To identify those who develop pulmonary embolism with Ddimer levels by evaluating pulmonary CT angiographies of patients who are followed up with suspicion of coronavirus disease 2019 (COVID-19). Methods. Patients who were followed up in a community hospital with suspicion of COVID-19 and underwent Pulmonary CT angiography examination were evaluated. Clinical and demographic parameters and DDimer values for patients with and without pulmonary embolism were evaluated in the pulmonary CT angiogram. Results. During the COVID-19 pandemic, Thorax CT examination was performed in our center for suspicion or follow-up of COVID-19 infection in 3396 patients. Pulmonary CT angiography was applied to 312 (9.2%) of these cases. Of these 312 patients, 141 were identified as COVID-19 patients. Acute pulmonary embolism was detected in 33 (23.4%) of 141 patients with COVID-19 and pulmonary CT angiogram. D-dimer levels (5964.97±4036.8 μg/L) of patients with COVID-19 infection and pulmonary embolism were significantly higher than D-dimer levels (972.4±1766.8 μg/L) of patients without pulmonary embolism. In patients with COVID-19 infection, a Ddimer value higher than 1013 μg/L was determined as a cut-off value with 100% sensitivity for the presence of pulmonary embolism. Conclusions. For those struggling with the COVID-19 pandemic, pulmonary embolism should be kept in mind if D-dimer values increase more than expected in the presence of respiratory distress that Thorax CT findings cannot explain.

scholarly journals Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected with Pulmonary CT Angiography

Radiology ◽  
2020 ◽  
Vol 296 (3) ◽  
pp. E186-E188 ◽  
Author(s):  
Franck Grillet ◽  
Julien Behr ◽  
Paul Calame ◽  
Sébastien Aubry ◽  
Eric Delabrousse
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
Pulmonary Ct

scholarly journals The Rate of Resolution of Clot Burden Measured by Pulmonary CT Angiography in Patients With Acute Pulmonary Embolism

2013 ◽  
Vol 200 (4) ◽  
pp. 791-797 ◽  
Author(s):  
Ayaz Aghayev ◽  
Alessandro Furlan ◽  
Amol Patil ◽  
Serter Gumus ◽  
Kyung Nyeo Jeon ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
Clot Burden ◽  
Pulmonary Ct

scholarly journals Acute Pulmonary Embolism in Patients with COVID-19 at CT Angiography and Relationship to d-Dimer Levels

Radiology ◽  
2020 ◽  
Vol 296 (3) ◽  
pp. E189-E191 ◽  
Author(s):  
Ian Léonard-Lorant ◽  
Xavier Delabranche ◽  
François Séverac ◽  
Julie Helms ◽  
Coralie Pauzet ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
D Dimer

State-of-the-Art Pulmonary CT Angiography for Acute Pulmonary Embolism

2017 ◽  
Vol 208 (3) ◽  
pp. 495-504 ◽  
Author(s):  
Moritz H. Albrecht ◽  
Matthew W. Bickford ◽  
John W. Nance ◽  
Longjiang Zhang ◽  
Carlo N. De Cecco ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
State Of The Art ◽  
Pulmonary Ct

Axial and Reformatted Four-Chamber Right Ventricle–to–Left Ventricle Diameter Ratios on Pulmonary CT Angiography as Predictors of Death After Acute Pulmonary Embolism

2012 ◽  
Vol 198 (6) ◽  
pp. 1353-1360 ◽  
Author(s):  
Michael T. Lu ◽  
Shadpour Demehri ◽  
Tianxi Cai ◽  
Layla Parast ◽  
Andetta R. Hunsaker ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Left Ventricle ◽  
Right Ventricle ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
Pulmonary Ct

Acute Pulmonary Embolism: When to Perform Pulmonary CT Angiography?

2009 ◽  
Vol 193 (3) ◽  
pp. W252-W252 ◽  
Author(s):  
Jyotindu Debnath
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Acute Pulmonary Embolism ◽  
Pulmonary Ct

Tissue plasminogen activator as a novel diagnostic aid in acute pulmonary embolism

VASA ◽  
2014 ◽  
Vol 43 (6) ◽  
pp. 450-458 ◽  
Author(s):  
Julio Flores ◽  
Ángel García-Avello ◽  
Esther Alonso ◽  
Antonio Ruíz ◽  
Olga Navarrete ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Negative Predictive Value ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Predictive Value ◽  
Acute Pulmonary Embolism ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diagnostic Utility ◽  
Tissue Plasminogen ◽  
D Dimer

Background: We evaluated the diagnostic efficacy of tissue plasminogen activator (tPA), using an enzyme-linked immunosorbent assay (ELISA) and compared it with an ELISA D-dimer (VIDAS D-dimer) in acute pulmonary embolism (PE). Patients and methods: We studied 127 consecutive outpatients with clinically suspected PE. The diagnosis of PE was based on a clinical probability pretest for PE and a strict protocol of imaging studies. A plasma sample to measure the levels of tPA and D-dimer was obtained at enrollment. Diagnostic accuracy for tPA and D-dimer was determined by the area under the receiver operating characteristic (ROC) curve. Sensitivity, specificity, predictive values, and the diagnostic utility of tPA with a cutoff of 8.5 ng/mL and D-dimer with a cutoff of 500 ng/mL, were calculated for PE diagnosis. Results: PE was confirmed in 41 patients (32 %). Areas under ROC curves were 0.86 for D-dimer and 0.71 for tPA. The sensitivity/negative predictive value for D-dimer using a cutoff of 500 ng/mL, and tPA using a cutoff of 8.5 ng/mL, were 95 % (95 % CI, 88–100 %)/95 % (95 % CI, 88–100 %) and 95 % (95 % CI, 88–100 %)/94 %), respectively. The diagnostic utility to exclude PE was 28.3 % (95 % CI, 21–37 %) for D-dimer and 24.4 % (95 % CI, 17–33 %) for tPA. Conclusions: The tPA with a cutoff of 8.5 ng/mL has a high sensitivity and negative predictive value for exclusion of PE, similar to those observed for the VIDAS D-dimer with a cutoff of 500 ng/mL, although the diagnostic utility was slightly higher for the D-dimer.

Overdiagnosis of Pulmonary Embolism by Pulmonary CT Angiography

2015 ◽  
Vol 205 (2) ◽  
pp. 271-277 ◽  
Author(s):  
Barry Donald Hutchinson ◽  
Patrick Navin ◽  
Edith M. Marom ◽  
Mylene T. Truong ◽  
John F. Bruzzi
Keyword(s):  
Pulmonary Embolism ◽  
Ct Angiography ◽  
Pulmonary Ct
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